Intracranial Hemorrhage in Children With Sickle Cell Disease

Hoff, Jack van; Ritchey, A. Kim; Shaywitz, Bennett A.

doi:10.1001/archpedi.1985.02140130058030

Cited by 19 publications

(12 citation statements)

References 19 publications

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“…274 In younger children with SCD, SAH probably stems from vascular fragility caused by the disease, but a significant number of adolescents and adults with SAH have an aneurysm or AVM and should be thoroughly evaluated for other causes. 277 Ten children (14.7%) in the above series also had congenital or acquired coagulation defects. 274 Factor VIII deficiency occurred in 3 children, and a coagulopathy caused by hepatic failure occurred in 2 others.…”

Section: Risk Factors For Ichmentioning

confidence: 88%

Management of Stroke in Infants and Children

Roach¹,

Golomb²,

Adams³

et al. 2008

Stroke

878

377

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Purpose— The purpose of this statement is to review the literature on childhood stroke and to provide recommendations for optimal diagnosis and treatment. This statement is intended for physicians who are responsible for diagnosing and treating infants, children, and adolescents with cerebrovascular disease. Methods— The Writing Group members were appointed by the American Heart Association Stroke Council’s Scientific Statement Oversight Committee. The panel included members with several different areas of expertise. Each of the panel’s recommendations was weighted by applying the American Heart Association Stroke Council’s Levels of Evidence grading algorithm. After being reviewed by panel members, the manuscript was reviewed by 4 expert peer reviewers and by members of the Stroke Council Leadership Committee and was approved by the American Heart Association Science Advisory and Coordinating Committee. We anticipate that this statement will need to be updated in 4 years. Results— Evidence-based recommendations are provided for the prevention of ischemic stroke caused by sickle cell disease, moyamoya disease, cervicocephalic arterial dissection, and cardiogenic embolism. Recommendations on the evaluation and management of hemorrhagic stroke also are provided. Protocols for dosing of heparin and warfarin in children are suggested. Also included are recommendations on the evaluation and management of perinatal stroke and cerebral sinovenous thrombosis in children.

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Section: Risk Factors For Ichmentioning

confidence: 88%

Management of Stroke in Infants and Children

Roach¹,

Golomb²,

Adams³

et al. 2008

Stroke

878

377

View full text Add to dashboard Cite

show abstract

“…However, other studies suggest that children are more likely to have subarachnoid hemorrhage without an identifiable aneurysm and hypothesized that both hemorrhage and infarcts are due to rheologic features of sickle cell. 8 Because of the recurrence of splenic sequestration in our patient, splenectomy was performed after the second episode, as severe splenic sequestration can result in fatality within hours. Because of its tendency to recur, splenectomy should be strongly considered if a child has had two or more of these episodes.…”

Section: Discussionmentioning

confidence: 94%

“…Homozygous patients have also been reported to show an increased incidence of subarachnoid hemorrhage, 7 however, it is known to occur more frequently in adults. 8 It has been shown that the incidence of hemorrhagic stroke in homozygous patients is highest among patients aged 20-29 years. 2 Our previous study showed a 10% prevalence of stroke in sickle cell disease patients in Madina Maternity and Children's Hospital, and none of the reported cases had intracranial hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Intracranial Hemorrhage Associated with Splenic Sequestration in a Saudi Child with Sickle Cell Anemia: Case Report and Review of the Literature

Hawsawi

2001

Annals of Saudi Medicine

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“…Moyamoya disease, resulting from collateral circulation related to obstruction in the anterior portion of the Circle of Willis, is a major predisposing factor for hemorrhagic events (Dobson et al, 2002). Subarachnoid hemorrhage is often associated with a ruptured intracranial aneurysm, although this occurs more commonly in adults than children (Oyesiku et al, 1991;Van Hoff, Ritchey, & Shaywitz, 1985). Risk factors for hemorrhagic stroke include low steady state hemoglobin and high leukocyte count (Ohene-Frempong et al, 1998).…”

Section: Strokementioning

confidence: 99%

Central Nervous System Complications of Sickle Cell Disease in Children: An Overview

Wang

2007

Child Neuropsychology

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Complications involving the central nervous system are among the most devastating manifestations of sickle cell disease. Although overt stroke occurs in 1 in 10 children with Hemoglobin SS, "silent cerebral infarcts" are even more frequent. Both are associated with significant neuropsychological deficits. The end result of these effects on the CNS often is diminished school performance. The use of transcranial Doppler ultrasonography screening allows the identification of patients at high risk for clinical stroke as well as stroke prevention by chronic transfusion. However, definitive prophylaxis and treatment for most CNS complications of sickle cell disease have yet to be determined.

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Intracranial Hemorrhage in Children With Sickle Cell Disease

Cited by 19 publications

References 19 publications

Management of Stroke in Infants and Children

Management of Stroke in Infants and Children

Intracranial Hemorrhage Associated with Splenic Sequestration in a Saudi Child with Sickle Cell Anemia: Case Report and Review of the Literature

Central Nervous System Complications of Sickle Cell Disease in Children: An Overview

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