Intracranial Hodgkin's disease. A report of 12 cases and review of the literature

Sapozink, Michael D.; Kaplan, Henry S.

doi:10.1002/1097-0142(19831001)52:7<1301::aid-cncr2820520728>3.0.co;2-5

Cited by 127 publications

(73 citation statements)

References 18 publications

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“…Because of the presence of fibrosis, RDD-CNS may have a distinctly nodular appearance suggestive of the nodular sclerosing variant of Hodgkin's disease. Hodgkin's disease occurring in the CNS is extremely rare and is typically associated with relapse (30). Although classic Reed Sternberg cells are readily distinguished from RDD histiocytes, mononuclear variants, particularly lacunar cells may mimic SHML histiocytes.…”

Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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Sinus histocytosis with massive lymphadenopathy, also known as Rosai-Dorfman Disease (RDD), is an idiopathic histiocytic proliferation affecting lymph nodes. Although extranodal involvement has been reported in diverse sites, central nervous system (CNS) manifestation, particularly in the absence of nodal disease is uncommon. We report 11 cases of RDD primary to the CNS without evidence of other sites of involvement. The cases included 7 males and 4 females ranging in age from 22 to 63 years (mean: 41 y). The patients presented with headaches, seizures, numbness, or paraplegia. Eight cases involved the cranial cavity and three cases, the spinal canal. Lesions were most often extra-axial and dura based. Only one presented in the CNS parenchyma. Histologically, the lesions consisted of variable numbers of pale-staining histocytes with emperipolesis often overshadowed by extensive lymphoplasmacytic infiltrates and fibrosis in the background. Special stains for organisms were negative. By immunohistochemical analysis, the characteristic histiocytes were positive for S100 protein and CD68 and negative for CD1a. Treatment consisted of surgical biopsy or excision. Follow-up, available for 10 cases with intervals ranging from 5 days to 42 months (mean: 15 mo), disclosed one patient dying of operative complications 5 days after biopsy and nine patients with no evidence of disease progression RDD should be considered in the differential diagnosis of inflammatory lesions of the CNS. Our study suggests that this entity may have been misdiagnosed in the past as plasma cell granuloma or inflammatory pseudotumor.

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Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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“…The incidence has been reported as 0.2% to 0.5% of all HL cases, but a recent review of 14 868 patients identified only 2 cases of HL involving the CNS. [1][2][3] Most reports consist of single cases or small case series highlighting our limited knowledge about the clinical characteristics, prognosis, and management of this neurologic complication of HL. [4][5][6][7][8] Consequently, there is no consensus to guide therapeutic decision-making.…”

Section: Introductionmentioning

confidence: 99%

CNS Hodgkin lymphoma

Gerstner

Abrey

Schiff

et al. 2008

Blood

101

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“…CNS Hodgkin's disease has been described in patients with disseminated disease, particularly those with relapse involving extranodal sites (Cuttner et al, 1979;Dujovny et al, 1980;Sapozink and Kaplan, 1983). Primary Hodgkin's disease isolated to the CNS is exceedingly rare (Algers et al, 1981;Wood and Coltman, 1973).…”

Section: Discussionmentioning

confidence: 99%

Primary Hodgkin's disease of the CNS in an immunocompetent patient: A case study and review of the literature

Biagi¹

2000

Neuro-Oncology

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Primary Hodgkin's disease limited to the CNS is exceedingly rare. Little is known regarding etiologic risk factors, optimal management, and prognosis. A case of Hodgkin's disease con ned to the CNS, with cerebrospinal uid negative for cytology, is described in an immunocompetent patient previously treated for hyperthyroidism with 131 I. The patient underwent craniotomy, with resection of two lesions in close proximity within the parenchyma of the temporoparietal lobe. Histopathology revealed classic nodular sclerosing Hodgkin's disease, without evidence of Epstein-Barr viral infection. Treatment included radiation to the whole brain with a boost to the tumor bed. The patient made a full neurologic recovery and remains free of disease recurrence 21 months after treatment. A literature review has identi ed only 9 additional cases. Seven of 8 evaluable patients remain alive and free of recurrence with a median follow-up of 13 months. The risk factors for this presentation remain unde ned. Although followup is short, radiotherapy alone appears to provide excellent disease-free survival. Chemotherapy may be reserved for patients with positive cerebrospinal uid, extracranial disease, or subsequent relapse. Neuro-Oncology 2, 239-243, 2000 (Posted to Neuro-Oncology [serial online], Doc. 00-028, September 6, 2000 H odgkin's disease with CNS involvement is uncommon, even in the HIV-positive population, and usually occurs in the setting of advanced or recurrent disease. Reports of primary Hodgkin's disease conned to the CNS are exceedingly rare. We describe a case of primary CNS Hodgkin's disease in a patient previously treated with 131 I for Grave's hyperthyroidism and review the literature with respect to potential risk factors, management, and treatment outcomes. Case StudyA 52-year-old right-handed male truck driver developed sudden onset of headache and confusion. He presented to the emergency department 2 days later with mild disorientation and receptive aphasia. Functional inquiry was negative for fatigue, weight loss, pruritis, fever, and night sweats. Physical examination revealed proptosis, but no evidence of peripheral adenopathy or hepatosplenomegaly. Assessment of cranial nerves, power, sensation, and coordination revealed no abnormalities.Past health included a history of Grave's hyperthyroidism with ophthalmopathy 4 years earlier. The patient was treated with radioactive iodine at a total dose of 229 mbq (6.2 mCi) administered orally. There was a 40-packyear smoking history . Medication on admission was limited to L-thyroxine, 0.125 mg per day. Family history was negative for cancer.Initial investigations revealed a normal complete blood cell count, peripheral blood smear, electrolytes, blood urea nitrogen, creatinine, random glucose, and international normalized ratio. Serum lactate dehydrogenase and erythrocyte sedimentation rate were not performed. A CT scan with contrast of the head revealed a contrast-enhancing 1.0 cm left temporoparietal lesion, with signi cant edema and mass effect (Fig. 1).

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Intracranial Hodgkin's disease. A report of 12 cases and review of the literature

Cited by 127 publications

References 18 publications

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

CNS Hodgkin lymphoma

Primary Hodgkin's disease of the CNS in an immunocompetent patient: A case study and review of the literature

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