Intracranial hypertension as an initial manifestation of spinal neuroectodermal tumor

Chen, Yi Chun; Tang, Lok‐Ming; Chen, Chi Jen; Jung, Shih Ming; Chen, Sien Tsong

doi:10.1016/j.clineuro.2004.09.011

Cited by 10 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By now, 106 cases[1–57–912–141617192325–32363841–5052–5456–6266–6870717377–79818486–9092939597–113115116] of primary intraspinal EES/pPNET (extradural/intradural extramedullary lesions) and 29 cases[31118202228353740515255697172808283859194114] of primary intramedullary PNET (CNS-PNET) have been reported in the literature [Tables 1 and 2]. In some studies, neither intra- nor extramedullary location of the tumor was mentioned, so they were not included in any of the groups in our review (i.e.…”

Section: Results Of the Meta-analysismentioning

confidence: 99%

Primary spinal extradural Ewing′s sarcoma (primitive neuroectodermal tumor): Report of a case and meta-analysis of the reported cases in the literature

Saeedinia¹,

Nouri²,

Alimohammadi³

et al. 2012

Surg Neurol Int

View full text Add to dashboard Cite

Background:Primary spinal primitive neuroectodermal tumors (PNET) and/or spinal extraskeletal Ewing's sarcoma family tumors (ESET) are rare lesions appearing in the spinal extradural space. One hundred forty-one primary spinal PNETs, including 29 intramedullary lesions, have been reported in the literature. Encountering a case of primary epidural EES/peripheral PNET (pPNET) in sacral level, which is the fifth one occurring at this level in the literature, we have tried to conduct a meta-analysis of the reported cases.Case Description:A 44-year-old lady with epidural EES/pPNET is reported here. She was once operated for L5/S1 herniated disc, which did not ameliorate her symptoms. The clinical, imaging, surgical, and histopathologic characteristics of our case are presented and wide search of the literature is also done. All the reports were level 3 or less evidences and most of the series had missing parts. 106 cases of primary intraspinal (extradural/extramedullary-intradural) EES/pPNET and 29 cases of primary intramedullary PNET (CNS-PNET) have been reported in the literature. The most common clinical presentation in both entities was muscle weakness proportionate to the tumor location. Distant metastasis occurred in 38 of 99 (38%) cases of primary intraspinal EES/pPNET, while the rate of metastasis was 48% in patients with PNETs occurring in the intramedullary region (P > 0.05). One-year survival rate of the patients who underwent chemo-radiation after total or subtotal resection was better than those who did not receive chemotherapy or radiotherapy, or did not have total or subtotal resection. However, this difference was not repeated in 2-year survival rate in any of the tumor groups.Conclusion:It seems that total or subtotal removal of the tumor and adjuvant chemo- and radiation therapy can improve the outcome in these patients.

show abstract

Section: Results Of the Meta-analysismentioning

confidence: 99%

Primary spinal extradural Ewing′s sarcoma (primitive neuroectodermal tumor): Report of a case and meta-analysis of the reported cases in the literature

Saeedinia¹,

Nouri²,

Alimohammadi³

et al. 2012

Surg Neurol Int

View full text Add to dashboard Cite

show abstract

“…Alexiou GA et al 4 reported a twomonth-old female of cervical-thoracic intramedullary PNET with concomitant hydrocephalus. Chen YC et al 13 also reported a intramedullary case with intracranial hypertension as an initial manifestation. The image examination results were similar to any other CNS malignancies originated from the neural stem cells, like glioma, lymphoma, etc.…”

Section: Discussionmentioning

confidence: 94%

Primary spinal primitive neuroectodermal tumor: A single center series with literature review

Yang

et al. 2018

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

Context: Primary spinal primitive neuroectodermal tumor (PNET) of the central nervous system has a low incidence. The intraspinal case is very rare. Around 30 cases have been reported so far. We summarized the cases of primary spinal PNET available in the database of our institute, either intramedullary or extramedullary cases. Then we did literature review of the same disease. Findings: There were eight cases of primary spinal PNET available in our database, with one intramedullary case and seven extramedullary cases. Surgical resection was performed. The histology diagnosis was PNET. Perioperative image examinations of the whole central nervous system (CNS) were performed to exclude tumors other than spinal cord origin. Then during literature review, 33 reports of the disease were included. The preoperative diagnosis rate was low. The disease had a high recurrence rate and poor prognosis given available treatment. Conclusion: Primary spinal primitive neuroectodermal tumor is of high malignancy. Little is known due to its quite low incidence. The prognosis is poor due to lacking of effective treatment strategy. Present treatment strategy is referred to other common CNS malignancies like glioma. Further investigation of the disease is necessary.

show abstract

“…[16] Whether there is a difference that is prevalence between sexes has not yet been fully established and is inconsistent across in different reports. [2510] The average age of presentation for patients with intraspinal PNETs was reported to be 24.1 years (but varying from 3 months to 69 years); this mean age is considered to be much higher than that for intracranial PNETs. [11] The duration of the disease is often short, typically <4 months and sometimes only a few days.…”

Section: Discussionmentioning

confidence: 99%

Cervicomedullary primitive neuroectodermal tumor of the spine: Case report

Nery¹,

Pereira²,

Costa³

et al. 2018

Surg Neurol Int

View full text Add to dashboard Cite

Background:Intramedullary primitive neuroectodermal tumors (PNETs) are tumors found rarely in the cervical region, with only five such cases described in the literature. The available literature contains only one report regarding cervicomedullary junction PNET.Case Description:The authors present a case report of a 45-year-old male patient who had undergone urgent hospitalization owing to progressive tetraparesis and subtle impairment of respiratory function. He underwent magnetic resonance imaging, which showed an extensive enhancing cervical intramedullary tumor extending from C5 to the bulbar region. Since he developed severe impairment of respiratory function, he required tracheostomy. He then underwent microsurgery 2 days after his admission, and a partial tumor resection was performed. The pathological diagnosis of PNET of the cervicomedullary junction (CMJ) was made. He had slight worsening of strength after surgery with subsequent deterioration over the next 3 weeks. The tumor displayed aggressive growth; thus, radiotherapy was indicated. Unfortunately, he developed severe febrile neutropenia and died after 2 weeks of radiotherapy. Given the rarity of the condition, we wish to review the epidemiology, pathophysiology, and treatment options of his population.Conclusion:Intramedullary PNETs of the cervical spine and CMJ are exceedingly rare in adults; treatment of such patients remains a challenge, despite the modern neurosurgical armamentarium that is available.

show abstract

Intracranial hypertension as an initial manifestation of spinal neuroectodermal tumor

Cited by 10 publications

References 22 publications

Primary spinal extradural Ewing′s sarcoma (primitive neuroectodermal tumor): Report of a case and meta-analysis of the reported cases in the literature

Primary spinal extradural Ewing′s sarcoma (primitive neuroectodermal tumor): Report of a case and meta-analysis of the reported cases in the literature

Primary spinal primitive neuroectodermal tumor: A single center series with literature review

Cervicomedullary primitive neuroectodermal tumor of the spine: Case report

Contact Info

Product

Resources

About