Intracranial Hypertension Associated With Testosterone Therapy In Female-To-Male Transgender Patients: A Case Report And Literature Review

Kamboj, Alisha; Brown, Meghan M.; Abel, Anne

doi:10.1080/08820538.2023.2169578

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…A recent review describes twenty transgender male patients who had been undergoing gaHRT and presented with intracranial hypertension, a condition characterised by increased intracranial pressure (ICP). They suggest an association with cerebral spinal fluid (CSF) hypoandrogenism (Kamboj et al, 2023). Chronic testosterone treatment in lean rat models led to an increase in ICP, potentially due to increased CSF secretion rate (Wardman et al, 2023).…”

Section: Vascular Research In Transgender Populations Undergoing Gahrtmentioning

confidence: 99%

A mini-review of the evidence for cerebrovascular changes following gender-affirming hormone replacement therapy and a call for increased focus on cerebrovascular transgender health

Wright,

Murphy

2023

Front. Hum. Neurosci.

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Gender-affirming hormone replacement therapy (gaHRT) is an important step for many in the gender diverse community, associated with increased quality-of-life and lower self-reported scores of depression and anxiety. However, considering the interactions that the involved sex hormones have on vasculature (with oestrogen and testosterone demonstrating vasodilatory and vasoconstricting properties, respectively), it is important for transgender healthcare research to examine how the manipulation of these hormones interact with cerebrovascular structure and functioning. There is a stark lack of research in this area. This mini-review outlines the research suggesting a vascular impact of these sex hormones using evidence from a range of cohorts (e.g., menopause, polycystic ovary syndrome) and discusses the work that has been done into cerebrovascular changes following gaHRT. Finally, recommendations for future research into cerebrovascular health in transgender cohorts following gaHRT are outlined.

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Section: Vascular Research In Transgender Populations Undergoing Gahrtmentioning

confidence: 99%

A mini-review of the evidence for cerebrovascular changes following gender-affirming hormone replacement therapy and a call for increased focus on cerebrovascular transgender health

Wright,

Murphy

2023

Front. Hum. Neurosci.

View full text Add to dashboard Cite

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Testosterone-cipionate

2023

Reactions Weekly

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Sex hormones, related compounds, and hormonal contraceptives including miscellaneous hormones

Shah,

Khan,

Patel

et al. 2024

Side Effects of Drugs Annual

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Intracranial Hypertension Associated With Testosterone Therapy In Female-To-Male Transgender Patients: A Case Report And Literature Review

Cited by 4 publications

References 25 publications

A mini-review of the evidence for cerebrovascular changes following gender-affirming hormone replacement therapy and a call for increased focus on cerebrovascular transgender health

A mini-review of the evidence for cerebrovascular changes following gender-affirming hormone replacement therapy and a call for increased focus on cerebrovascular transgender health

Testosterone-cipionate

Sex hormones, related compounds, and hormonal contraceptives including miscellaneous hormones

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