Intracranial Intra-arachnoid Diverticula and Cyst-like Abnormalities of the Brain

Platt, Simon R.; Hicks, Jill; Matiasek, Lara

doi:10.1016/j.cvsm.2015.10.004

Cited by 22 publications

(33 citation statements)

References 57 publications

(134 reference statements)

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“…The clinical-imaging exclusion criteria were inspired by Dolera [ 10 ], and implemented as followed: Previous chemotherapy or surgical treatment of the tumour; Lesion localization close to a vascular territory of a main cerebral artery or a perforating artery with sharp demarcation [ 42 ], strong hyperintensity in the diffusion image and hypointensity on ADC (Apparent Diffusion Coefficient) map [ 40 ] suggesting a vascular origin [ 40 , 42 , 46 ]; Fever/other symptoms or blood abnormalities correlated with inflammation, presence of any predisposing factor to infection, image characteristics of an abscess (T2-Weighted images (T2-WI) hypointense peripheral rim or peripheral concentric “onion skin like” hypointense rim, thick strong peripheral rim contrast enhancement [ 47 ] or a granuloma (dural contact, T2-WI hypointensity) [ 48 ] and concurrent findings of meningitis [ 48 , 49 ]; these aspects were considered indicative of inflammatory diseases [ 38 ]; Well defined rounded structure, isolated or in continuity with ventricles and cisterns with thin, smooth non-enhancing walls and content resembling cerebrospinal fluid (CSF) or fat, that did not display contrast enhancement, were considered congenital intracranial cysts (arachnoid or dermoid cysts) [ 50 ]. …”

Section: Methodsmentioning

confidence: 99%

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Definitive-intent uniform megavoltage fractioned radiotherapy protocol for presumed canine intracranial gliomas: retrospective analysis of survival and prognostic factors in 38 cases (2013–2019)

Debreuque

Fornel²,

David

et al. 2020

BMC Vet Res

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Background Radiotherapy (RT) is currently considered the treatment of choice for presumed canine intracranial gliomas. However, variable therapeutic responses are described, due to heterogeneous populations and different radiation methods or protocols. Only one study dedicated to intracranial suspected glioma highlighted prognostic criteria. Determination or confirmation of specific clinical and imaging prognostic factors may guide the therapeutic management of these tumours. The objectives were to provide data on long-term clinical outcome (including quality of life, QoL) and to determine specific prognostic factors associated with survival time. We report a single-institution retrospective study, including all dogs with suspected symptomatic primary solitary intracranial glioma, treated with a complete uniform fractionated megavoltage radiation protocol of 15x3Gy over 5 weeks, between January 2013 and February 2019. Thirty-eight client-owned dogs were included. Medical records were retrospectively evaluated for median overall survival time (MST), clinical and imaging responses. Prognostic factors on survival were researched in terms of signalment, clinical presentation, tumour imaging characteristics and response following RT. Finally, the RT’s impact on the dogs’ clinical signs and Qol were evaluated by the owners. Results The disease-specific MST was 698 days (95% CI: 598–1135). Survival at 1 and 2 years were respectively 74.2 ± 7.4% and 49.0 ± 9.8%. Initial clinical signs were related to survival, as well as tumour characteristics such as cystic-pattern, mass effect and Tumour/Brain volume ratio. No significant adverse effect or radiotoxicity was observed. Conclusions RT appears as a safe and effective treatment for canine intracranial gliomas, allowing long-term tumour control, improvement of life’s quality and management of associated clinical signs. The initial clinical signs and MRI characteristics (Tumour/Brain volume ratio, cyst-like lesion and mass effect) may help predict the prognosis.

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Section: Methodsmentioning

confidence: 99%

“…Well defined rounded structure, isolated or in continuity with ventricles and cisterns with thin, smooth non-enhancing walls and content resembling cerebrospinal fluid (CSF) or fat, that did not display contrast enhancement, were considered congenital intracranial cysts (arachnoid or dermoid cysts) [ 50 ].…”

Section: Methodsmentioning

confidence: 99%

Definitive-intent uniform megavoltage fractioned radiotherapy protocol for presumed canine intracranial gliomas: retrospective analysis of survival and prognostic factors in 38 cases (2013–2019)

Debreuque

Fornel²,

David

et al. 2020

BMC Vet Res

View full text Add to dashboard Cite

show abstract

“…Well de ned rounded structure, isolated or in continuity with ventricles and cisterns with thin, smooth non-enhancing walls and content resembling cerebrospinal uid (CSF) or fat, that did not display contrast enhancement, were considered congenital intracranial cysts (arachnoid or dermoid cysts) [31].…”

Section: Dogs and Tumour Characteristicsmentioning

confidence: 99%

Definitive-intent uniform megavoltage fractioned radiotherapy protocol for presumed canine intracranial gliomas: retrospective analysis of survival and prognostic factors in 38 cases (2013-2019).

Debreuque

DEFORNEL²,

David

et al. 2020

Preprint

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Background : Radiotherapy (RT) is currently considered the treatment of choice for presumed canine intracranial gliomas. However, variable therapeutic responses are described, due to heterogeneous populations and different radiation methods or protocols. Only one study dedicated to intracranial suspected glioma highlighted prognostic criteria. Determination or confirmation of specific clinical and imaging prognostic factors may guide the therapeutic management of these tumours. The objectives were to provide data on long-term clinical outcome (including quality of life, QoL) and to determine specific prognostic factors associated with survival time. We report a single-institution retrospective study, including all dogs with suspected symptomatic primary solitary intracranial glioma, treated with a complete uniform fractionated megavoltage radiation protocol of 15x3Gy over 5 weeks, between January 2013 and February 2019. Thirty-eight client-owned dogs were included. Medical records were retrospectively evaluated for median overall survival time (MST), clinical and imaging responses. Prognostic factors on survival were researched in terms of signalment, clinical presentation, tumour imaging characteristics and response following RT. Finally, the RT’s impact on the dogs’ clinical signs and Qol were evaluated by the owners. Results: The disease-specific MST was 698 days (95% CI: 598-1135). Survival at 1 and 2 years were respectively 74.2±7.4% and 49.0±9.8%. Initial clinical signs were related to survival, as well as tumour characteristics such as cystic-pattern, mass effect and Tumour/Brain volume ratio. No significant adverse effect or radiotoxicity was observed. Conclusions: RT appears as a safe and effective treatment for canine intracranial gliomas, allowing long-term tumour control, improvement of life’s quality and management of associated clinical signs. The initial clinical signs and MRI characteristics (Tumour/Brain volume ratio, cyst-like lesion and mass effect) may help predict the prognosis.

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“…Non-neoplastic intracranial cysts can cause clinical signs due to compression of the brain [18]. Intracranial cysts include arachnoid diverticula, epidermoid cysts, dermoid cysts, ependymal cysts, porencephalic cysts, and choroid plexus cysts.…”

mentioning

confidence: 99%

Intracranial ectopic choroid plexus cyst in a dog

Nishida

Yamazaki

Sakai

et al. 2019

The Journal of Veterinary Medical Science

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A 4-year-old male Toy Poodle was presented with a history of status epilepticus. On presentation, neurological examination revealed a delay in postural reactions in the right pelvic limb. Magnetic resonance imaging showed a fluid-containing cystic lesion that compressed the mesencephalon, hippocampus, and amygdala. The cyst was surgically removed via left rostrotentorial craniotomy. The final diagnosis was an intracranial ectopic choroid plexus cyst. The patient has remained free of seizures for 18 months after surgery. This is the first case report of an intracranial ectopic choroid plexus cyst that was surgically removed in a dog.

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Intracranial Intra-arachnoid Diverticula and Cyst-like Abnormalities of the Brain

Cited by 22 publications

References 57 publications

Definitive-intent uniform megavoltage fractioned radiotherapy protocol for presumed canine intracranial gliomas: retrospective analysis of survival and prognostic factors in 38 cases (2013–2019)

Definitive-intent uniform megavoltage fractioned radiotherapy protocol for presumed canine intracranial gliomas: retrospective analysis of survival and prognostic factors in 38 cases (2013–2019)

Definitive-intent uniform megavoltage fractioned radiotherapy protocol for presumed canine intracranial gliomas: retrospective analysis of survival and prognostic factors in 38 cases (2013-2019).

Intracranial ectopic choroid plexus cyst in a dog

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