Intracranial Involvement by Plasma Cell Neoplasms

Wilberger, Adam; Prayson, Richard A.

doi:10.1093/ajcp/aqw058

Cited by 11 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Solitary cranial plasmacytoma occurs rarely and usually occurs as a manifestation of multiple myeloma as in this case [2-4,6]. However, spontaneous involution of a plasmacytoma without therapeutic intervention has not been previously reported.…”

Section: Discussionmentioning

confidence: 94%

Calvarial Plasmacytoma Mimicking Meningioma as the Initial Presentation of Multiple Myeloma

Morgenstern

Pisapia

Ramakrishna

2017

Cureus

View full text Add to dashboard Cite

Plasmacytoma of the calvarium is a well-described feature of multiple myeloma and in some cases has been reported as a solitary lesion. However, when associated with multiple myeloma these are typically identified after the initial diagnosis is made. This case is unusual in that the diagnosis of plasmacytoma was first suspected in a patient thought to have a meningioma on the day of surgery, when a magnetic resonance imaging (MRI) demonstrated spontaneous involution of the mass. Recognition of evolving changes in a calvarial or dural-based lesion should prompt the practitioner to consider alternative diagnoses other than meningioma prior to proceeding with surgical resection.

show abstract

Section: Discussionmentioning

confidence: 94%

Calvarial Plasmacytoma Mimicking Meningioma as the Initial Presentation of Multiple Myeloma

Morgenstern

Pisapia

Ramakrishna

2017

Cureus

View full text Add to dashboard Cite

show abstract

“…The majority of CNS cases are found in relapsed disease; however, most of these cases typically present as a leptomeningeal rather than an intraparenchymal process. Several cases of solitary intracranial plasmacytoma have been reported, but these are typically intraosseous tumors [ 3 , 8 , 9 , 10 ]. Extraosseous intracranial plasmacytoma is rarely seen with relapsed disease.…”

Section: Discussionmentioning

confidence: 99%

“…Central nervous system (CNS) involvement of multiple myeloma is rare, with an incidence rate reported around 1% [ 1 , 2 ]. Most of these cases involve lepto-meningeal disease, with intracranial plasmacytoma being less frequent, especially following treatment of myeloma [ 3 ]. Similarly, malignant pericardial effusion from extramedullary multiple myeloma is uncommon, especially following hematopoietic stem cell transplantation (HSCT) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Relapsed Multiple Myeloma Presenting as Intracranial Plasmacytoma and Malignant Pericardial Effusion following Recent Allogeneic Stem Cell Transplantation

et al. 2017

View full text Add to dashboard Cite

Although rare, both central nervous system and pericardial involvement of myeloma have been well described in the literature. Their simultaneous occurrence in relapsed disease, however, has not been previously reported. This case describes a 54-year-old female who was treated for high-risk multiple myeloma with multiregimen chemotherapy and allogeneic hematopoietic stem cell transplantation. Four months after transplant, she was found to have relapsed disease manifesting as an extraosseous, intracranial plasmacytoma and simultaneous malignant pericardial effusion. Her disease characteristics, treatment course, radiologic and pathologic findings are described in detail, and we review the previous literature to determine the various aspects of her disease that may have contributed to her aggressive clinical course.

show abstract

“…The differential diagnosis for plasmacytoma mainly includes meningioma, metastasis, sarcoma, chordoma, eosinophilic granuloma, osteosarcoma and giant cell tumour [8,11,20]. Meningioma usually shows iso to hyperdensity with homogenous enhancement and a "dura tail".…”

Section: Arch Clinmentioning

confidence: 99%

Imaging Findings of Solitary Plasmacytoma of the Cranium

Sukriti¹,

Li²,

Zhao³

2018

Arch Clin Med Case Rep

View full text Add to dashboard Cite

Solitary plasmacytoma of bone (SBP) are extremely rare and limited in the English literature. The most common locations in the skull are sphenoid bone, juxtasellar region, petrous apex and cerebral convexity or falx. SBP has higher risk of advancing to Multiple Myeloma within the duration of 2-4 years. Here we report two cases involving the cranium, both the cases initially mis-diagnosed as meningioma and after histopathology report confirmed as plasmacytoma. Further laboratory investigations were made to rule out multiple myeloma and its systemic involvement. We will also further discuss about the CT and MRI features and the most common differential diagnosis of SBP.

show abstract

Intracranial Involvement by Plasma Cell Neoplasms

Abstract: PCNs rarely arise in the intracranial compartment. Intracranial PCN may be the initial presentation of MM. Anecdotally, blastic morphology appears to manifest more aggressive behavior.

Cited by 11 publications

References 13 publications

Calvarial Plasmacytoma Mimicking Meningioma as the Initial Presentation of Multiple Myeloma

Calvarial Plasmacytoma Mimicking Meningioma as the Initial Presentation of Multiple Myeloma

Relapsed Multiple Myeloma Presenting as Intracranial Plasmacytoma and Malignant Pericardial Effusion following Recent Allogeneic Stem Cell Transplantation

Imaging Findings of Solitary Plasmacytoma of the Cranium

Contact Info

Product

Resources

About