Intracranial lipomas: clinical appearances on neuroimaging and clinical significance

Jabot, G.; Stoquart-ElSankari, Souraya; Saliou, Guillaume; Toussaint, P.; Deramond, H.; Lehmann, P.

doi:10.1007/s00415-009-5087-5

Cited by 57 publications

(68 citation statements)

References 4 publications

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“…These benign lesions are thought to arise from differentiation of the meninx primitiva, a mesenchymal derivative of neural crest, to lipoma tissue. The vast majority of these types of lesions occur near the midline [1] . More than 50% have been reported to be associated with congenital brain malformations such as agenesis or hypoplasia of the corpus callosum [2] .…”

Section: Discussionmentioning

confidence: 99%

“…More than 50% have been reported to be associated with congenital brain malformations such as agenesis or hypoplasia of the corpus callosum [2] . Others include the absence of the septum pellucidum, cranium bifidum, spina bifida, myelomeningocele, hypoplasia of the vermis and malformation of the cortex [1] . In this case, we found that the septum pallucidum was absent [ Figure 4].…”

Section: Discussionmentioning

confidence: 99%

“…Intracranial lipomas are generally congenital, benign malformations and most frequently located in the midline areas [1] . CT and MRI are usually sufficient for diagnosis of lipomas because of very low attenuation value on CT and short T1 and T2 on MRI and therefore histopathological confirmation is practically not required.…”

Section: Introductionmentioning

confidence: 99%

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A rare case of quadrigeminal plate lipoma presenting with the sixth cranial nerve palsy

Chaurasia¹,

Shalike²,

Chaudhary³

et al. 2017

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Intracranial lipomas are rare benign tumour that is slow growing, generally asymptomatic, most frequently located in the midline areas and are usually an incidental finding on imaging and therefore cases are not frequently reported. This study reports a case of a patient with quadrigeminal plate lipoma presenting with obstructive hydrocephalous and the 6th cranial nerve palsy that was successfully treated with ventriculo-peritoneal shunting without addressing the lesion. Key words: Lipoma, quadrigeminal plate, the 6th cranial nerve palsy, hydrocephalus ABSTRACTArticle history:

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A rare case of quadrigeminal plate lipoma presenting with the sixth cranial nerve palsy

Chaurasia¹,

Shalike²,

Chaudhary³

et al. 2017

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show abstract

“…Intracranial lipomas affect more frequently females than males (2:1) [3]. Most lipomas occur at or near the midline, and only 9-12% are found in the CPA [4,6,7]. In symptomatic cases lipomas of the CPA can cause vertigo, dizziness, tinnitus, and loss of hearing [3,4,8].…”

Section: Introductionmentioning

confidence: 99%

“…They are rare congenital abnormalities, which are not true neoplasms. They originate from the primitive meninx and contain adipose tissue [3,4,5,6]. Intracranial lipomas affect more frequently females than males (2:1) [3].…”

Section: Introductionmentioning

confidence: 99%

Trigeminal Neuralgia Associated with Cerebellopontine Angle Lipoma in Childhood

Egemen¹,

Börcek²,

Karaaslan³

et al. 2012

Pediatr Neurosurg

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Cerebellopontine angle lipomas are rare and more rarely associated with trigeminal neuralgia especially in childhood. Medical treatment provides relief from the pain; however, the effect may not be permanent. Surgical treatment is associated with a high morbidity rate; therefore, surgery should be considered only in intractable cases. In this article we describe the clinical course and radiological features of a 6-year-old girl with a cerebellopontine angle lipoma who presented with a 4-year history of left-side trigeminal neuralgia, especially in the mandibular area. Magnetic resonance imaging revealed an extra-axial fatty mass at the level of the ‘dorsal-entry zone' of the trigeminal nerve. The pain improved with carbamazepine therapy.

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Craniofacial features resembling frontonasal dysplasia with a tubulonodular interhemispheric lipoma in the adult 3H1 tuft mouse

Fong

Cooper

Drumhiller

et al. 2012

Birth Defects Research

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Intracranial lipomas are rare, but 45% of them occur along the midline cisterns between the hemispheres and are often associated with corpus callosum hypoplasia and craniofacial defects. They are difficult to detect, as they are generally asymptomatic and visible by MRI or by postmortem examination. The exact cause of these interhemispheric lipomas is not known, but they arise from a developmental defect resulting in the maldifferentiation of mesenchymal cells into mesodermal derivatives that are not normally present. We have identified a new mouse mutant called tuft, exhibiting a forebrain, intracranial lipoma with midline craniofacial defects resembling frontonasal dysplasia (FND) that arose spontaneously in our wild-type 3H1 colony. The tuft trait appears to be transmitted in recessive fashion, but approximately 80% less frequent than the expected Mendelian 25%, due to either incomplete penetrance or prenatal lethality. MRI and histological analysis revealed that the intracranial lipoma occurred between the hemispheres and often protruded through the sagittal suture. We also observed a lesion at the lamina terminalis that may indicate improper closure of the anterior neuropore. We have mapped the tuft trait to within an 18 cM region on mouse chromosome 10 by microsatellite linkage analysis and identified several candidate genes involved with craniofacial development and cellular differentiation of adipose tissue. tuft is the only known mouse model for midline craniofacial defects with an intracranial lipoma. Identifying the gene(s) and mutation(s) causing this early developmental defect will help us understand the pathogenesis of FND and related craniofacial disorders.

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Intracranial lipomas: clinical appearances on neuroimaging and clinical significance

Cited by 57 publications

References 4 publications

A rare case of quadrigeminal plate lipoma presenting with the sixth cranial nerve palsy

A rare case of quadrigeminal plate lipoma presenting with the sixth cranial nerve palsy

Trigeminal Neuralgia Associated with Cerebellopontine Angle Lipoma in Childhood

Craniofacial features resembling frontonasal dysplasia with a tubulonodular interhemispheric lipoma in the adult 3H1 tuft mouse

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