Intracranial malignant nerve sheath tumor in the middle cranial fossa: A rare case report with review of literature

Patankar, Amey P.; Sheth, Jwalit Hasmukhlal

doi:10.4103/ajns.ajns_59_19

Cited by 10 publications

(10 citation statements)

References 5 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After the surgery patient developed facial palsy. Histopathology revealed the tumor to be a malignant nerve sheath tumor; in contrast, the biopsy, in our case, revealed schwannoma, and the patient developed hearing loss [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Curious Case of Acoustic Schwannoma of Middle Cranial Fossa: A Case Report

Singh

Dua

Dhar

et al. 2022

Brain Tumor Res Treat

View full text Add to dashboard Cite

Acoustic neuromas are the most common lesion in the cerebellopontine angle. The authors report a unique case of acoustic schwannoma, presenting in middle cranial fossa masquerading as meningioma in a 24-year-old man, presenting with headache and focal seizures. Contrast-enhanced MRI of the brain revealed a mass lesion of the right middle cranial fossa consistent with features of meningioma. Intraoperatively a well-defined tumor with attachment to anterior petrous bone was excised. In the immediate postoperative period, the patient developed right-sided hearing loss, which was proven to be retrochoclear hearing loss on brainstem evoked response audiometry. Histopathology findings were consistent with benign schwannoma. Acoustic schwannoma originating in an unusual location middle cranial fossa is a plausible explanation of such unusual occurrence. Such a case has never been reported in the literature.

show abstract

Section: Discussionmentioning

confidence: 99%

Curious Case of Acoustic Schwannoma of Middle Cranial Fossa: A Case Report

Singh

Dua

Dhar

et al. 2022

Brain Tumor Res Treat

View full text Add to dashboard Cite

show abstract

“…В доступной нам современной отечественной и зарубежной литературе имеются немногочи-КЛИНИЧЕСКИЕ СЛУЧАИ / CLINICAL CASES сленные описания отдельных клинических наблюдений злокачественной опухоли оболочек периферического нерва параспинальной локализации, тем более при развитии метастатического каскада [4,5,7,8,10,15].…”

Section: Discussionunclassified

“…Клиническая картина заболевания ЗОПН может манифестировать развитием болевого корешкового синдрома, таким образом напоминать другие патологические процессы (остеохондроз, плазмоцитома, опухоли костной ткани), а последующий инфильтративный рост опухоли в окружающие мягкие ткани и позвоночный столб может затруднить правильную прижизненную диагностику. В этой связи важным является своевременное выполнение МРТ-исследования, биопсии опухоли с последующим выполнением иммуногистохимического исследования, которые позволят установить диагноз, о чем свидетельствуют данные литературы [10,11]. В связи с редкостью, особенностями локализации ЗОПН в параспинальной области, быстрым инфильтративным ростом и гематогенной диссеминацией во внутренние органы, трудностями ее прижизненной диагностики, приводим собственное секционное наблюдение с морфологическим и иммуногистохимическим описанием.…”

Section: Introductionunclassified

Peripheral nerve sheath malignancy with multiple metastasis: a rare clinical case

Todorov

Deribas

Казьмин

et al. 2021

Kuban. nauсh. med. vestnik

View full text Add to dashboard Cite

Background. Tumours of peripheral nervous system are represented by benign and malignant neoplasms with different clinical and biological traits. Malignant peripheral nerve sheath tumours of paraspinal localisation with the involvement of nerve structures are extremely rare and may occur isolated or comorbid with congenital neurofibromatosis. Current literature contains a few bioptic and selected autopsy clinical reports. Herewith, we present an own sectional observation of a rare malignant peripheral nerve sheath tumour with multiple metastasis supplemented with morphological and immunohistochemical descriptions.Clinical Case Description. An autopsy was performed on a 30-yo man’s cadaver. A tumour infiltrate was observed along Th5—Th9 of the spinal column intimately associated with thoracic vertebral bodies. Metastases were detected in the right lung, myocardium, peripancreatic and perirenal adipose tissue. Histological tumour examination revealed heterogeneous solid and rosette-like structures. Tumour immunophenotype: vimentin+, pancytokeratin-, CD45-, S-100+, NSE+, GFAP-, proliferative activity index (Ki-67 = 75-80%). This profile is descriptive of peripheral nerve sheath malignancy of high grade with multiple organic metastases.Conclusion. The sectional observation presented illustrates the difficulty to in vivo diagnose rare peripheral nerve sheath malignancies due to their infiltrative growth into spinal bone marrow and metastasis to organs (lungs, myocardium, peripancreatic and perirenal adipose tissue).

show abstract

“…It is now avoided in NF1-related LGGs, due to the known risk of secondary malignancies and radiation-induced vasculopathies [25,58,60]. We also recorded the case of an 11-year-old patient with intracerebral MPNST and a 4-year-old with schwannoma (Figure 1), which are both very rare in NF1 patients and exceptionally rare in childhood [61][62][63][64][65][66][67].…”

Section: Discussionmentioning

confidence: 99%

Retrospective Multicentric Study on Non-Optic CNS Tumors in Children and Adolescents with Neurofibromatosis Type 1

Santoro

Picariello

Palladino

et al. 2020

Cancers

View full text Add to dashboard Cite

The natural history of non-optic central nervous system (CNS) tumors in neurofibromatosis type 1 (NF1) is largely unknown. Here, we describe prevalence, clinical presentation, treatment, and outcome of 49 non-optic CNS tumors observed in 35 pediatric patients (0–18 years). Patient- and tumor-related data were recorded. Overall survival (OS) and progression-free survival (PFS) were evaluated. Eighteen patients (51%) harbored an optic pathway glioma (OPG) and eight (23%) had multiple non-optic CNS lesions. The majority of lesions (37/49) were managed with a wait-and-see strategy, with one regression and five reductions observed. Twenty-one lesions (42.9%) required surgical treatment. Five-year OS was 85.3%. Twenty-four patients progressed with a 5-year PFS of 41.4%. Patients with multiple low-grade gliomas progressed earlier and had a lower 5-year PFS than those with one lesion only (14.3% vs. 57.9%), irrespective of OPG co-presence. Non-optic CNS tumors are common in young patients with NF1. Neither age and symptoms at diagnosis nor tumor location influenced time to progression in our series. Patients with multiple lesions tended to have a lower age at onset and to progress earlier, but with a good OS.

show abstract

Intracranial malignant nerve sheath tumor in the middle cranial fossa: A rare case report with review of literature

Cited by 10 publications

References 5 publications

Curious Case of Acoustic Schwannoma of Middle Cranial Fossa: A Case Report

Curious Case of Acoustic Schwannoma of Middle Cranial Fossa: A Case Report

Peripheral nerve sheath malignancy with multiple metastasis: a rare clinical case

Retrospective Multicentric Study on Non-Optic CNS Tumors in Children and Adolescents with Neurofibromatosis Type 1

Contact Info

Product

Resources

About