Intracranial meningeal hemangiopericytoma: The role of radiotherapy

Soyuer, Serdar; Chang, Eric L.; Selek, Uğur; McCutcheon, Ian E.; Maor, Moshe

doi:10.1002/cncr.20109

Cited by 168 publications

(162 citation statements)

References 27 publications

(57 reference statements)

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…Aggressive gross total resection (GTR) has been advocated by most as reports have found greater recurrence-free interval (RFI) and overall survival (OS) in patients [5,[17][18][19][20][21]. Schiariti et al [20] reported that patients with GTR had both longer mean OS (235 vs. 175 months, respectively; p = 0.47) and mean RFI (117 vs. 53 months, respectively; p = 0.0045).…”

Section: Surgical Treatmentmentioning

confidence: 99%

Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

et al. 2013

View full text Add to dashboard Cite

Purpose Hemangiopericytoma (HPC) is a rare tumor of the central nervous system. Primary spinal occurrence of this tumor is extremely uncommon and cases involving the intramedullary spinal cord are even more rare. The purpose of this study was to explore the clinical features, surgical strategies, outcome and pathology in a consecutive series of patients treated at a single institution. Methods The authors performed a retrospective review of the clinicopathological characteristics of four patients with a pathological diagnosis of spinal HPC. Results Four cases with intradural as well as intra/extramedullary components were identified. Gross total resection with no recurrence at the operative site was achieved in the majority of patients with a spinal HPC. One patient had significant recurrence and eventually, succumbed to the disease. Conclusion Increased awareness of these tumors' capability to occur intradurally and intramedullarly can help surgeons accurately diagnose and choose an effective plan of care. Gross total resection of hemangiopericytomas is the mainstay of treatment and should be pursued if feasible. Histopathology is essential to the diagnosis.

show abstract

Section: Surgical Treatmentmentioning

confidence: 99%

Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

et al. 2013

View full text Add to dashboard Cite

show abstract

“…3,7,8,10,12,20) Total resection of HPC and adjuvant radiotherapy are effective. 8,20) Local control rates were 84% for total resections and 38% for partial resections (non-significant) 5 years after surgery, and no local recurrence was found after total resection and adjuvant radiotherapy, whereas local recurrence was found in 45% of patients without adjuvant radiotherapy after total resection (non-significant). 20) Preoperative radiotherapy caused tumor shrinking, resulting in less bleeding during surgery.…”

Section: Discussionmentioning

confidence: 99%

Hemangiopericytoma in the Lateral Ventricle -Case Report-

Suzuki

Wanifuchi

Shimizu

et al. 2009

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 31-year-old female presented with a particularly rare hemangiopericytoma (HPC) in the right lateral ventricle manifesting as a 6-month history of visual disturbance and headache. Left hemianopsia and choked disc were identified by an ophthalmologist who referred her to us. Magnetic resonance imaging demonstrated a 5-cm homogeneously enhanced mass in the trigone of the right lateral ventricle. The tumor was totally removed by two stage surgery. The histological findings were consistent with HPC. HPC is very important to differentiate from meningioma and solitary fibrous tumors because HPC is more aggressive. The histological and immunochemical findings are important for the differential diagnosis. The present case showed no local recurrence or metastasis without radiation therapy for 4 years, indicating that radiation therapy is not absolutely imperative for patients with intraventricular HPC showing low MIB-1 staining index after total removal.

show abstract

“…14,15 Intracranial HPCs represent less than 1% of all intracranial tumors and approximately 2%-4% of all meningeal tumors. 1,17,26,28,29 They almost always present as solitary, supratentorial (62%) dura-based lesions often arising from the falx, tentorium, dural sinuses, and skull base. Histopathologically, they are characterized by spindle cells with a rich vascular network, with large, dilated, "staghorn" vascular channels (Fig.…”

Section: Pathological Features and Presentationmentioning

confidence: 99%

“…Because of the high vascularity of the lesions, preoperative embolization can sometimes be advantageous. Soyuer et al 29 reported a superior 5-year local control rate in patients treated with GTR (84%) as compared with the rate in patients treated using subtotal resection (38%). Radiotherapy.…”

Section: Multimodal Managementmentioning

confidence: 99%

“…7,[11][12][13]21,25 The response of HPCs to radiotherapy is dose dependent, with overall treatment doses of 45 Gy or higher resulting in superior local control. 6 The current SRT treatment plan used in most centers delivers 46-52 Gy fractionated over [25][26][27][28][29][30][31][32][33][34][35] sessions. In recent years, SRT has emerged as a viable salvage strategy for the treatment of recurrent intracranial HPCs, ideally less than 3 cm in their greatest dimension.…”

Section: Multimodal Managementmentioning

confidence: 99%

See 1 more Smart Citation

Hemangiopericytomas of the skull base

Schirmer¹,

Heilman²

2011

FOC

View full text Add to dashboard Cite

Object Intracranial hemangiopericytomas are frequently located along the dural sinuses along the skull base and represent rare, aggressive CNS neoplasms that are difficult to distinguish from meningiomas based on both imaging and gross characteristics. The authors of this study describe 3 patients with these lesions and review the pertinent literature. Methods Two men and 1 woman, whose median age at the time of the initial presentation was 37 years (range 20–53 years), constitute this series. They underwent multimodal treatment consisting of resection, embolization, radiation therapy, and in 1 case chemotherapy. Results Two of the 3 patients treated were alive after a mean follow-up of 93 months (range 4–217 months). One patient died 217 months after the initial diagnosis. The longest tumor progression–free interval after the initial or secondary resection was 43 months (range 4–84 months). Conclusions Hemangiopericytomas have been reclassified as mesenchymal nonmeningothelial tumors. They have an inevitable tendency to recur locally and metastasize distally. The mainstay of therapy remains an aggressive attempt to achieve gross-total resection at the initial surgery. Postoperative adjuvant radiotherapy should be offered to all patients, regardless of the degree of resection achieved. Diligent long-term follow-up is paramount as local recurrences and distal metastases can develop sometimes years after the initial treatment.

show abstract

Intracranial meningeal hemangiopericytoma: The role of radiotherapy

Cited by 168 publications

References 27 publications

Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

Surgical management of primary spinal hemangiopericytomas: an institutional case series and review of the literature

Hemangiopericytoma in the Lateral Ventricle -Case Report-

Hemangiopericytomas of the skull base

Contact Info

Product

Resources

About