Intracranial meningeal melanocytoma associated with nevus of Ota

Pān, Hào; Wang, Handong; Fan, Youwu

doi:10.1016/j.jocn.2011.01.040

Cited by 21 publications

(9 citation statements)

References 10 publications

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“…Histopathologically, melanocytoma shows a heavily pigmented cellular proliferation with scant mitotic figure . Meningeal melanocytomas associated with nevus of Ota involving the central nervous system have been reported previously . These are similar to our case, showing dermal melanocytosis with melanocytoma, and reflecting embryogenic aberrant migration of precursor cells.…”

Section: Discussionsupporting

confidence: 90%

“…13 Meningeal melanocytomas associated with nevus of Ota involving the central nervous system have been reported previously. [14][15][16] These are similar to our case, showing dermal melanocytosis with melanocytoma, and reflecting embryogenic aberrant migration of precursor cells. However, melanocytoma is a neuropathology term, not described in the skin.…”

Section: Discussionsupporting

confidence: 88%

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A cellular blue nevus with pigmented epithelioid melanocytoma‐like pattern on the ipsilateral upper arm associated with a congenital plaque‐type blue nevus on the hand

et al. 2019

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A 36‐year‐old man presented with a subcutaneous nodule on the right upper arm. A small nodule had developed 8 years earlier, and grew in size, accompanied by a tingling sensation and numbness. In addition, he had a bluish irregular patch on the right hand since birth, which crossed from the palm to the dorsal hand. Skin biopsies from the hand showed a heavily pigmented melanocyte proliferation in the dermis with perieccrine, perivascular, and perineural involvement, and a diagnosis of congenital plaque‐type blue nevus was made. The tumor on the arm was located closely along the median nerve, and was observed as a large black pedunculated round tumor. Histopathologically, the tumor on the arm consisted of densely packed tissue with nevoid cells without atypia in the larger nodular part, and heavily pigmented spindle and epithelioid melanocytes in the slender stalk area, which was diagnosed as cellular blue nevus with pigmented epithelioid melanocytoma‐like pattern. Next‐generation sequencing revealed GNAQ mutations in the hand lesion, and in the lesions on the arm. This case suggests that the areas of skin following the same neural distribution of a congenital plaque‐type blue nevus on the extremities should be followed up for secondary changes.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

A cellular blue nevus with pigmented epithelioid melanocytoma‐like pattern on the ipsilateral upper arm associated with a congenital plaque‐type blue nevus on the hand

et al. 2019

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“…Furthermore, the association of PMMT with nevus of Ota is also rare. Among 10 cases of benign melanocytoma associated with nevus of Ota, seven were alive after a follow-up varying from 6 months to 9 years [1,[4][5][6][7][8][9][10][11][12]. The current case is, to our knowledge, the second reported case of IGM associated with nevus of Ota.…”

Section: Pathologymentioning

confidence: 93%

“…PMMTs are usually located in the leptomeninges adjacent to medulla oblongata and anterolateral spinal cord [2]. Synchronous occurrence of melanocytoma and nevus of Ota is rare, with only 10 previously reported cases to our knowledge [1,[4][5][6][7][8][9][10][11][12]. Synchronous occurrence of melanocytoma and nevus of Ota is rare, with only 10 previously reported cases to our knowledge [1,[4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Intermediate-grade meningeal melanocytoma associated with nevus of Ota

et al. 2015

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Meningeal melanocytomas are rare melanin-producing tumors that are often found to be benign. However, a small subset of these tumors can present as intermediate-grade melanocytomas (IGMs) that have histopathological features that are between those of benign melanocytomas and malignant melanomas. IGMs have the potential to recur and metastasize or progress to a more histologically high grade melanoma. Melanocytomas appear to differ from primary and metastatic melanoma by their prolonged clinical course and they appear to have different driver mutations (i.e. mutation of GNAQ gene). The association of a meningeal melanocytoma with nevus of Ota is extremely rare. To our knowledge, there have been only 10 reported cases of synchronous occurrence and only one of the cases involved an IGM. We report the second case of intermediate-grade meningeal melanocytoma that is associated with congenital nevus of Ota. Histopathological work-up confirmed the intermediate grade of the lesion and a driver GNAQ mutation was identified consistent with previous reports.

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“…Bizim vakamızda bilateral sklera ve fasiyal bölge tutulumu vardı, mukozal tutulum mevcut değildi. Leptomeningeal tutulum ve melanoma gelişimi olan vaka bildirimleri mevcuttur [9,10].…”

Section: Olgu Sunumuunclassified

Bilateral Ota nevus in a 15 years old patient

Öztürk¹,

Uçak²,

Erden³

2013

DicleMedj

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Nevus of Ota is a dermal melanocytosis, clinically localized on skin that is innervated by the first and second branches of the trigeminal nerve. It occurs almost entirely in Asian people. The clinical manifestations are usually unilateral; only 5% of cases are bilateral. In this article, due to rarity of the case, a 15-year-old patient, who was diagnosed with bilateral ota nevus, without having any dermatological complaints other than cosmetic appearence and stains in her eyes and around was presented.

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Intracranial meningeal melanocytoma associated with nevus of Ota

Cited by 21 publications

References 10 publications

A cellular blue nevus with pigmented epithelioid melanocytoma‐like pattern on the ipsilateral upper arm associated with a congenital plaque‐type blue nevus on the hand

A cellular blue nevus with pigmented epithelioid melanocytoma‐like pattern on the ipsilateral upper arm associated with a congenital plaque‐type blue nevus on the hand

Intermediate-grade meningeal melanocytoma associated with nevus of Ota

Bilateral Ota nevus in a 15 years old patient

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