Intracranial meningeal melanocytoma: CT and MRI

Chen, C. J.; Hsu, Yung-Hsin; Ho, Yat‐Sen; Hsu, Yu‐Chao; Wang, L. J.; Wong, Yon-Cheong

doi:10.1007/s002340050510

Cited by 65 publications

(46 citation statements)

References 16 publications

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“…The tumor occurs almost exclusively in the posterior fossa and spinal cord. 6,7,10,11 The annual incidence of MM is estimated to be 1 case per 10 million people, and women are vulnerable. 10 Our hospital has an extremely large collection area for patients from Guangdong province and 4 neighboring provinces.…”

Section: Discussionmentioning

confidence: 99%

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MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Hou

Sun

Zhang

et al. 2012

AJNR Am J Neuroradiol

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SUMMARY:Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.ABBREVIATIONS: EMA ϭ epithelial membrane antigen; HMB-45 ϭ human melanoma black-45; IHC ϭ immunohistochemistry; MM ϭ meningeal melanocytoma P rimary melanocytic neoplasms of the CNS are lesions arising from melanocytes of the leptomeninges. Melanocytes are melanin-producing cells that derive from the neural crest during embryogenesis and then migrate to the skin, mucous membranes, and CNS.

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Section: Discussionmentioning

confidence: 99%

“…The average age in our series is 49.2 years, which is consistent with that in other reports. 10,11 Approximate 59 cases of intraspinal MM have been reported. 5 Nineteen cases were founded in the intramedullary location, while others were located in the extramedullary area.…”

Section: Discussionmentioning

confidence: 99%

MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Hou

Sun

Zhang

et al. 2012

AJNR Am J Neuroradiol

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“…12) Generally there is no evidence of necrosis or hemorrhage. 3) Immunohistochemical and ultrastructural findings are useful to differentiate meningeal melanocytoma from meningioma and melanoma. Immunohistochemistry shows a positive reaction for HMB-45 and S-100 protein.…”

Section: Discussionmentioning

confidence: 99%

Meningeal Melanocytoma Extruded From the Skull of a Neonate -Case Report-

Nakahara

Morota

Ihara

et al. 2010

Neurol. Med. Chir.(Tokyo)

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Ultrasonography performed at 21 weeks of gestation and magnetic resonance imaging at 23 weeks identified a huge tumor in the occipital region. Premature rupture of the membrane occurred at 28 weeks of gestation, so this baby boy was delivered by emergency cesarean section. Anemia and low blood pressure due to hemorrhage from the surface of the tumor required massive blood transfusion and hemostasis. The tumor was conservatively managed. He manifested symptoms of high output heart failure and persistent infection, necrotizing enterocolitis, and septicemia, and died 51 days after birth. Autopsy examination found the black tumor, weighing 885 g, with a clear boundary with the brain parenchyma. Histological examination showed the tumor was contiguous with the thickened dura mater. The tumor consisted of small, spindle-shaped, round, and polygonal cells without characteristic organized pattern, and positive for S-100 protein and neuron-specific enolase, and negative for HMB-45 and glial fibrillary acidic protein. Ultrastructural study revealed melanin granules within the tumor cells. The diagnosis was meningeal melanocytoma. His skin and spinal cord were unremarkable. Complete tumor resection is considered the best treatment option, followed by incomplete resection with postoperative radiotherapy, but we could not deliver aggressive treatment in our patient because of hemorrhage from the tumor surface and his poor general condition.

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“…By depending on the propensity to cell type, these cells may include various amounts of cytoplasm and melanin pigment [5, 14, 19, 23, 32], and usually a large nucleus with prominent nucleoli [5, 11, 14, 17, 18, 46]. Necrosis and hemorrhage are usually absent, but presence of rare mitotic figures is frequently reported [12, 14, 18, 19, 21, 23, 24].…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance findings do not reflect a typical signal pattern in these lesions [5, 17, 19, 32, 47]. Melanin pigment includes paramagnetic free radicals and decreases T 1 and T 2 relaxation times [17].…”

Section: Discussionmentioning

confidence: 99%

Benign Melanocytic Tumor in Infancy: Discussion on a Rare Case and Review of the Literature

Oruçkaptan¹,

Söylemezoğlu²,

Kutluk³

et al. 2000

Pediatr Neurosurg

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Meningeal melanocytoma is an infrequent neoplasm of the central nervous system (CNS), especially in childhood and infancy. It was first described as an entity different from pigmented meningiomas and schwannomas in 1972, and few cases have been published so far. In this article, a 5-month-old male patient with meningeal melanocytoma is presented. This midline lesion was localized in the posterior fossa and manifested by hydrocephalus. The entire dural origin and extradural growing pattern in addition to the destruction of the adjacent occipital bone were the unexpected presentations since these tumors usually tend to locate on leptomeninges and to extend into the adjacent neural compartment rather than the outside. On the other hand, this case is the only one which had identical lesions in both surrenal glands and the left renal capsule, the structures containing neural-crest-derived cells outside the CNS. The prognostic criteria, differential diagnosis and its embryological aspects are discussed with an extensive review of the related existing literature.

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Intracranial meningeal melanocytoma: CT and MRI

Cited by 65 publications

References 16 publications

MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Meningeal Melanocytoma Extruded From the Skull of a Neonate -Case Report-

Benign Melanocytic Tumor in Infancy: Discussion on a Rare Case and Review of the Literature

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