Intracranial plasma cell granuloma

West, Sterling G.; Pittman, David L.; Coggin, Julian T.

doi:10.1002/1097-0142(19800715)46:2<330::aid-cncr2820460220>3.0.co;2-m

Cited by 103 publications

(43 citation statements)

References 17 publications

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“…As described in the literature, plasma cell granuloma is a discrete, dura-based inflammatory mass with associated fibrosis (33)(34)(35)(36). We believe that many lesions previously reported as CNS plasma cell granulomas or inflammatory pseudotumors are, in fact, RDD-CNS.…”

Section: Discussionmentioning

confidence: 66%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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Sinus histocytosis with massive lymphadenopathy, also known as Rosai-Dorfman Disease (RDD), is an idiopathic histiocytic proliferation affecting lymph nodes. Although extranodal involvement has been reported in diverse sites, central nervous system (CNS) manifestation, particularly in the absence of nodal disease is uncommon. We report 11 cases of RDD primary to the CNS without evidence of other sites of involvement. The cases included 7 males and 4 females ranging in age from 22 to 63 years (mean: 41 y). The patients presented with headaches, seizures, numbness, or paraplegia. Eight cases involved the cranial cavity and three cases, the spinal canal. Lesions were most often extra-axial and dura based. Only one presented in the CNS parenchyma. Histologically, the lesions consisted of variable numbers of pale-staining histocytes with emperipolesis often overshadowed by extensive lymphoplasmacytic infiltrates and fibrosis in the background. Special stains for organisms were negative. By immunohistochemical analysis, the characteristic histiocytes were positive for S100 protein and CD68 and negative for CD1a. Treatment consisted of surgical biopsy or excision. Follow-up, available for 10 cases with intervals ranging from 5 days to 42 months (mean: 15 mo), disclosed one patient dying of operative complications 5 days after biopsy and nine patients with no evidence of disease progression RDD should be considered in the differential diagnosis of inflammatory lesions of the CNS. Our study suggests that this entity may have been misdiagnosed in the past as plasma cell granuloma or inflammatory pseudotumor.

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Section: Discussionmentioning

confidence: 66%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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“…Most cases reported thereafter have had the involvement of the lungs or upper respiratory tract and other organ systems. West et al 17) , were the first to describe patient with primary intracranial plasma cell granuloma and since then, about 60 cases have been reported in the literature 11) . In particular, only 4 cases of plasma cell granuloma involving the falx or tentorium have been reported.…”

Section: Discussionmentioning

confidence: 99%

Intracranial Plasma Cell Granuloma

Kim

Choi

Song

et al. 2009

J Korean Neurosurg Soc

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J Korean Neurosurg Soc 46 : [161][162][163][164] 2009 Plasma cell granuloma is a tumor-like disease characterized by non-neoplastic polyclonal proliferation of plasma cells and other mononuclear cells. This disease occurs most frequently in the lung and upper respiratory tract, while the involvement of the central nervous system is very rare. A 44-year-old female patient presented with nausea and progressive visual disturbance. Brain magnetic resonance imaging (MRI) revealed the mass along the right tentorium with low signal intensity in the T2 weighted image (T2WI) and fluid-attenuated inversion recovery (FLAIR) sequence, and an isosignal intensity in T1 weighted image (T1WI), the latter of which was enhanced after administration of gadoliniumdiethylenetriamine penta-acetic acid (Gd-DTPA). The thickest portion of the tentorium was partially excised via the combined suboccipital and infratentorial approach. The histopathological examination indicated a diagnosis of plasma cell granuloma. Postoperative steroid therapy was administered for remnant tumor control. Although a follow up MRI scan taken 20 months after the operation showed a slight decrease in tumor size, the lesion had extended to the falx and left frontal convexity along with parenchymal edema at 32 months after the operation and the clinical status was aggravated. The mass was removed from the left frontal convexity. Radiation therapy was given, together with steroid administration.

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“…Meningeal inflammatory masses of the dura [20] constitute an heterogeneous group of uncertain etiology that has been reported under various names such as plasma cell granuloma [5,20,31], hyalinizing plasmacytic granulomatosis [23] or inflammatory pseudo-tumour [5] because of their similarity to the lesions described in the lungs and other tissues [4]. The proportions of inflammatory and meningothelial components varied from case to case; some might have been true meningioma with a striking inflammatory component [11,20], other were inflammatory masses with nests of trapped hyperplastic meningothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic hypertrophic cranial pachymeningitis mimicking multiple meningiomas: case report and review of the literature

Deprez

Born

Hauwaert

et al. 1997

Acta Neuropathologica

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A case of idiopathic hypertrophic cranial pachymeningitis with an unusual and misleading manifestation is reported. Computed tomography scan, angiographic and magnetic resonance imaging findings were suggestive of multiple meningeal neoplasms and a correct diagnosis was made only after meningeal biopsy. This 44-yearold patient had a previous history of an ill-defined systemic disorder associating episcleritis, erythroderma nodosa and multiple peripheral arthritis. We review previous reports of idiopathic cranial pachymeningitis with emphasis on radiological investigation techniques, histopathology and possible dysimmune mechanisms of pathogenesis.

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Intracranial plasma cell granuloma

Cited by 103 publications

References 17 publications

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

Intracranial Plasma Cell Granuloma

Idiopathic hypertrophic cranial pachymeningitis mimicking multiple meningiomas: case report and review of the literature

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