Intracranial pressure after phenoperidine

Grummitt, R.M.; Goat, V. A.

doi:10.1111/j.1365-2044.1984.tb07363.x

Cited by 15 publications

(2 citation statements)

References 9 publications

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“…In this respect there was no difference between the effects of phenoperidine alone or phenoperidine combined with pancuronium. These results are in agreement with the observations of Grummitt and Goat (1984), who suggested that phenoperidine may actively increase cerebral blood flow (CBF), and therefore ICP, by inducing cerebral vasodilatation.…”

Section: Discussionsupporting

confidence: 93%

Influence of Bolus Doses of Phenoperidine on Intracranial Pressure and Systemic Arterial Pressure in Traumatic Coma

Bingham

Hinds

1987

British Journal of Anaesthesia

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The effects of bolus doses of phenoperidine 1-2 mg i.v. either alone, or combined with pancuronium 2-4 mg, were investigated in seven patients in traumatic coma. Phenoperidine alone significantly reduced mean arterial pressure (MAP) by a mean (+/- SEM) of 13.2 (+/- 2.8) mm Hg. Overall there was no significant change in intracranial pressure (ICP) despite the decreases in MAP and, consequently, cerebral perfusion pressure (CPP) decreased (14.0 +/- 2.4 mm Hg) on all but one occasion. In some instances these decreases were considerable (maximum 38 mm Hg). Similar results were obtained when phenoperidine was combined with pancuronium. These findings suggest that the bolus administration of phenoperidine and probably other opiates should be avoided in traumatic coma.

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