Intracranial pure yolk sac tumor in the anterior third ventricle of an adult: A case report

Zhao, Suhong; Shao, Guangrui; Guo, Weihua; Chen, Xiubin; Li, Renjie

doi:10.3892/etm.2014.1945

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…In most cases, the onset of YST occurs in childhood and young adulthood. In the relevant English literature, there are only 5 reported cases of YST in patients over 35 years old (Table 1) (23)(24)(25)(26)(27). Our case represents the fourth-oldest patient with adult-onset yolk sac tumor reported worldwide.…”

Section: Discussionmentioning

confidence: 86%

Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review

et al. 2023

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Yolk sac tumor (YST) is a rare primary brain tumor that occurs almost exclusively in patients under 30 years old. Intracranial germ cell tumors are most frequently located in the pineal and suprasellar region. Medulla oblongata YSTs are particularly rare. Extragonadal YSTs may be difficult to diagnose because of their characteristics, such as the rarity and variety of growth patterns. Furthermore, they are known to have a very poor prognosis. We herein report a case of YST of the medulla oblongata in a 50-year-old woman. She was followed up for 18 months without any tumor recurrence.

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Section: Discussionmentioning

confidence: 86%

Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review

et al. 2023

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“…Serum AFP level is a common indicator for evaluating the treatment response to YSTs. [7] Studies have shown that serum AFP >1000 ng/mL at the time of diagnosis is a risk factor for subsequent [10] M 23 Pineal region No Yes No NR 2017 [11] M 17 Hypothalamic and Pineal region Yes Yes Yes Alive 2014 [12] M 2 Cerebellar vermis Yes Yes No NR 2014 [13] F 45…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary treatment of primary intracranial yolk sac tumor

Yue

Cao

et al. 2021

Medicine

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Rationale: Intracranial yolk sac tumors (YSTs) are rare malignancies with limited treatment options and a dismal prognosis. They are usually managed with surgical resection and chemoradiotherapy. Patient concerns: Here, we report a patient with primary YST in the pineal region who achieved long term survival. Despite undergoing treatment, he experienced several recurrences over a 15-year period. Diagnosis: Brain magnetic resonance imaging (MRI) demonstrated the presence of space-occupying lesions in the pineal region and the medial tail of the left lateral ventricle. The tumors were excised, and the histological diagnosis suggested an intracranial YST. Interventions: The patient achieved long term survival after combined modality therapy including surgery, stereotactic radiosurgery (SRS)/intensity modulated radiation therapy (IMRT), chemotherapy, and targeted therapy. Outcomes: The disease remained stable. However, the patient gave up treatment and passed away in October 2020, with a total survival of about 15 years. Lessons: To the best of our knowledge, this patient with intracranial YST had received a longer survival compared with other published reports. We summarize previously published reports of intracranial YST and discuss the importance of multidisciplinary treatment. SRS may have a role, as a focal boost to residual tumor after resection or in case of recurrence after conventional radiotherapy, in the multimodality management of intracranial YSTs.

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“…The majority of locations are near the midline, such as the saddle and pineal region, basal ganglia and the thalamus (24,4,12), a few may occur in the lateral ventricles, third ventricle, cerebral hemispheres or brainstem (1,19,25). The imaging diagnosis of intracranial germ cell tumors in typical regions are more clear, but in rare site are easily misdiagnosed.…”

Section: Discussionmentioning

confidence: 99%

“…The germinomas is most common in germ cell tumors, followed by teratoma, endodermal sinus tumor and choriocarcinoma are rare (10). The majority of locations are near the midline, such as the saddle and pineal region, basal ganglia and the thalamus (24,4,12), a few may occur in the lateral ventricles, third ventricle, cerebral hemispheres or brainstem (1,19,25). On review of literature, very few case reports of yolk sac tumor have been published.…”

Section: Introductionmentioning

confidence: 99%

A Case Report of Yolk Sac Tumor in Cerebellar Hemisphere and Review of Literature

Zhang

Ling

2020

Preprint

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Abstract Background: Yolk sac tumor also known as endodermal sinus tumor, is a rare intracranial germ cell tumor. We reported a case of yolk sac tumor in cerebellar hemisphere, and reviewed associated literatures. The majority of tumor locations are near the midline. On review of literature, very few case reports of intracranial yolk sac tumor have been published, and there is only one case report has described a yolk sac tumor arising from the cerebellum. Case presentation: A two years old boy admitted to our hospital due to headache and unsteady gait for six days. CT and MRI demonstrated a tumor in the right cerebellar hemisphere, and the blood and cerebrospinal fluid alpha-fetoprotein were found increased. It was diagnosed as yolk sac tumor after operation comfirmed by histopathological examination. Postoperative chemotherapy was performed, and the patient suffered no tumor recurrence one year and a half after the surgery. Conclusions: The clinical characteristics and imaging diagnosis of intracranial yolk sac tumor are lack of specificity, the comfirmed diagnosis is depending on the combination of elevated alpha-fetoprotein and histopathological examination.

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Intracranial pure yolk sac tumor in the anterior third ventricle of an adult: A case report

Cited by 13 publications

References 9 publications

Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review

Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review

Multidisciplinary treatment of primary intracranial yolk sac tumor

A Case Report of Yolk Sac Tumor in Cerebellar Hemisphere and Review of Literature

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