Intracranial Sensors for Continuous Monitoring of Neurophysiology

Jiang, Nan; Flyax, Sergey; Kurz, Wolfgang; Jakobi, Martin; Koch, Alexander W.; Yetisen, Ali K.

doi:10.1002/admt.202100339

Cited by 9 publications

(23 citation statements)

References 143 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, spurred by the advancements in material synthesis and processing technologies, flexible pressure sensors have increasingly seized the spotlight due to their remarkable integration, lightweight, and surface adaptability, particularly within the realm of medical monitoring. − Their implementation offers patients a safer and more comfortable means of monitoring their health status . The human skin surface, known for its intricate and irregular topography, presents a plethora of potential applications for flexible pressure sensors, encompassing crucial metrics like blood pressure, , heart rate, , respiratory rate, − pulse beat, − intracranial pressure, , intraocular pressure, , and external pressures including gait analysis, − tactile perception, , and speech recognition. − These applications demonstrate the immense potential of flexible pressure sensors in the field of medical monitoring. Flexible pressure sensors typically employ four primary sensing mechanisms: piezoresistive, capacitive, piezoelectric, and triboelectric .…”

Section: Introductionmentioning

confidence: 99%

“… 1 − 3 Their implementation offers patients a safer and more comfortable means of monitoring their health status. 4 The human skin surface, known for its intricate and irregular topography, presents a plethora of potential applications for flexible pressure sensors, 5 encompassing crucial metrics like blood pressure, 6 , 7 heart rate, 8 , 9 respiratory rate, 10 − 12 pulse beat, 13 − 15 intracranial pressure, 16 , 17 intraocular pressure, 18 , 19 and external pressures including gait analysis, 20 − 22 tactile perception, 23 , 24 and speech recognition. 25 − 27 These applications demonstrate the immense potential of flexible pressure sensors in the field of medical monitoring.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High-Sensitivity Flexible Capacitive Pressure Sensors Based on Biomimetic Hibiscus Flower Microstructures

Lan,

Zhang,

Chen

et al. 2024

ACS Omega

View full text Add to dashboard Cite

The integration of low-dimensional nanomaterials with microscale architectures in flexible pressure sensors has garnered significant interest due to their outstanding performance in healthcare monitoring. However, achieving high sensitivity across different magnitudes of external pressure remains a critical challenge. Herein, we present a high-performance flexible pressure sensor crafted from biomimetic hibiscus flower microstructures coated with silver nanowires. When compared with a flat electrode, these microstructures as electrodes display significantly enhanced sensitivity and an extended stimulus−response range. Furthermore, we utilized an ionic gel film as the dielectric layer, resulting in an enhancement of the overall performance of the flexible pressure sensor through an increase in interfacial capacitance. Consequently, the capacitive pressure sensor exhibits an extraordinary ultrahigh sensitivity of 48.57 [Kpa] −1 within the pressure range of 0−1 Kpa, 15.24 [Kpa] −1 within the pressure range of 1−30 Kpa, and 3.74 [Kpa] −1 within the pressure range of 30−120 Kpa, accompanied by a rapid response time (<58 ms). The exceptional performance of our flexible pressure sensor serves as a foundation for its numerous applications in healthcare monitoring. Notably, the flexible pressure sensor excels not only in detecting subtle physiological signals such as finger and wrist pulse signals, vocal cord vibrations, and breathing intensity but also demonstrates excellent performance in monitoring higher pressures, such as plantar pressure. We foresee that this flexible pressure sensor possesses significant potential in the field of wearable electronics.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High-Sensitivity Flexible Capacitive Pressure Sensors Based on Biomimetic Hibiscus Flower Microstructures

Lan,

Zhang,

Chen

et al. 2024

ACS Omega

View full text Add to dashboard Cite

show abstract

“…[ 1 ] Emerging artificial synapses offer a favorable option to replace the sensory process of human being, which help sensory‐handicap patients and intelligent products to perceive different stimuli. Many efforts have been made to establish multifunctional sensory systems, such as silicon electronic sensor for monitoring intracranial pressure and temperature [ 2 ] and graphene/MoS 2 heterostructure for mechano‐photonic artificial synapses. [ 3 ] However, these devices are operated with high voltage, going against reducing energy consumption.…”

Section: Introductionmentioning

confidence: 99%

Ultralow‐Power and Multisensory Artificial Synapse Based on Electrolyte‐Gated Vertical Organic Transistors

Liu

Shi

et al. 2022

Adv Funct Materials

View full text Add to dashboard Cite

Bioinspired electronics have shown great potential in the field of artificial intelligence and brain-like science. Low energy consumption and multifunction are key factors for its application. Here, multisensory artificial synapse and neural networks based on electrolyte-gated vertical organic field-effect transistors (VOFETs) are first developed. The channel length of the organic transistor is scaled down to 30 nm through cross-linking strategy. Owing to the short channel length and extremely large capacitance of the electric double layer formed at the electrolyte-channel interface, the minimum power consumption of one synaptic event is 0.06 fJ, which is significantly lower than that required by biological synapses (1-10 fJ). Moreover, the artificial synapse can be trained to learn and memory images in a 5 × 5 synapse array and emulate the human brain's spatiotemporal information processing and sound azimuth detection. Finally, the artificial tongue is designed using the synaptic transistor that can discriminate acidity. Overall, this study provides new insights into realizing energy-efficient artificial synapses and mimicking biological sensory systems.

show abstract

“…[ 5 ] Recently, some temperature‐responsive fluorescent materials have been developed for non‐contact temperature sensing based on their temperature‐dependent fluorescence intensity or lifetime. [ 4b,6 ] Li et al. reported a NIR‐II dual ratiometric luminescence nanothermometer (DRLNT) to specifically monitor temperature fluctuations in biological systems.…”

Section: Introductionmentioning

confidence: 99%

Precise Synergistic Photothermal Therapy Guided by Accurate Temperature‐Dependent NIR‐II Fluorescence Imaging

Sun,

Li,

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Photothermal therapy (PTT) is considered a promising treatment strategy for solid tumors. However, local hyperthermia (over 45°C) during PTT can cause severe side effects in neighboring healthy tissues. PTT with accurate temperature feedback is a compelling strategy to ablate tumors and reduce side effects, but it still faces challenges. Here, a new kind of phototheranostic nanoparticle, namely 17‐RF@Ag2Se is developed, enabling in vivo NIR‐II fluorescence tracking, PTT and fluorescence nanothermometry as well as synergistic heat‐shock protein (HSP) inhibition. Precise PTT with high spatiotemporal resolution is achieved with the help of the designed NIR‐II fluorescence imaging‐photothermal therapy linkage apparatus. Upon intravenous injection, 17‐RF@Ag2Se is specifically accumulated in tumors targeted by the overexpressed integrin αvβ3, which is monitored by NIR‐II fluorescence imaging of Ag2Se QDs. Further, the release of HSP inhibitor, tanespimycin (17‐AAG), enhances the thermosensitivity of tumor cells. Subsequently, the internal temperature of the tumor is precisely monitored and adjusted during PTT via the temperature‐dependent NIR‐II fluorescence feedback of Ag2Se QDs and the linkage apparatus calibration, thereby achieving efficient and safe tumor PTT. Also, the results present a new method for accurate temperature monitoring and control in vivo, which can be applied to other biomedical studies.

show abstract

Intracranial Sensors for Continuous Monitoring of Neurophysiology

Abstract: SensorLong term mean zero-drift Thermal drift Neurovent-P 0.6 ± 0.96 mmHg (after 5 days) ≈ 0.2 mmHg/20 °C Codman MicroSensor <1 mmHg after 24 h ≈ 0.026 mmHg/°C Pressio <0.05 mmHg difference to Codman MicroSensor ≈ 0.3 mmHg/20 °C

Cited by 9 publications

References 143 publications

High-Sensitivity Flexible Capacitive Pressure Sensors Based on Biomimetic Hibiscus Flower Microstructures

High-Sensitivity Flexible Capacitive Pressure Sensors Based on Biomimetic Hibiscus Flower Microstructures

Ultralow‐Power and Multisensory Artificial Synapse Based on Electrolyte‐Gated Vertical Organic Transistors

Precise Synergistic Photothermal Therapy Guided by Accurate Temperature‐Dependent NIR‐II Fluorescence Imaging

Contact Info

Product

Resources

About