Intracranial solitary fibrous tumors: Clinical, radiological, and histopathological insights along with review of literature

Khan, Adil Aziz; Ahuja, Sana; Mankotia, Dipanker Singh; Zaheer, Sufian

doi:10.1016/j.prp.2024.155456

Pathology - Research and Practice

2024

DOI: 10.1016/j.prp.2024.155456

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Intracranial solitary fibrous tumors: Clinical, radiological, and histopathological insights along with review of literature

Adil Aziz Khan,

Sana Ahuja,

Dipanker Singh Mankotia

et al.

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2024

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Cited by 3 publications

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Intracranial solitary fibrous tumour with rhabdomyosarcomatous differentiation: A diagnostic challenge of a rare presentation

Teckchandani,

Chohan,

Zaheer

2024

International Journal of Surgery Case Reports

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Intracranial solitary fibrous tumour with rhabdomyosarcomatous differentiation: A diagnostic challenge of a rare presentation

Teckchandani,

Chohan,

Zaheer

2024

International Journal of Surgery Case Reports

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Solitary fibrous tumor of the orbit: The importance of the histopathological diagnosis of the hemangiopericytoma pattern

Bertazzo,

Trottier,

Santos

et al. 2024

The Pan-American Journal of Ophthalmology

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Purpose: The diagnoses of solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) have evolved over the past decades. Due to histopathological similarities, they were grouped as the same entity highlighting the complexity of this rare condition. Previous studies suggest that orbital HPC-pattern tumors are more aggressive than SFTs. We analyzed the histopathological and immunohistochemical features of patients with orbital SFT/HPC to further classify this entity. Materials and Methods: We reviewed eight orbital SFT/HPC cases from McGill University Health Centre (2011–2019). All of them were diagnosed as SFT, three with HPC pattern. Vascular proliferation (HPC) and spindle cell morphology (SFT) were evaluated. The tumors were stained with STAT6, CD34, Ki67, SMA, EMA, and S100 protein and further analyzed. Results: The average age was 49 years, and seven were male. Follow-up ranged from 6 to 96 months. Three patients (two males and one female) had an HPC pattern (average age of 54 years). Five male patients had only SFT pattern (average age of 46 years). In HPC cases, STAT6 was negative, CD34 and SMA were positive, S100 protein and EMA were negative, and Ki67 was low (5%–10%). In SFT cases, STAT6 and SMA were positive, CD34 was positive (in spindle cells and vessels for two cases, vessels only in three), S100 protein and EMA were negative, and Ki67 was low (5%–20%). Conclusion: These results highlight the pathological variability of orbital SFT/HPC. Immunohistochemical profiling helps differentiate between SFT and SFT with HPC pattern, which is essential, as HPC have a higher risk of recurrence and malignant transformation.

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An Invasive Solitary Fibrous Tumor/Hemangiopericytoma Originating From the Falx: A Case Report

Başkurt,

Şeker,

Avci

2024

Cureus

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Intracranial solitary fibrous tumors: Clinical, radiological, and histopathological insights along with review of literature

Cited by 3 publications

References 39 publications

Intracranial solitary fibrous tumour with rhabdomyosarcomatous differentiation: A diagnostic challenge of a rare presentation

Intracranial solitary fibrous tumour with rhabdomyosarcomatous differentiation: A diagnostic challenge of a rare presentation

Solitary fibrous tumor of the orbit: The importance of the histopathological diagnosis of the hemangiopericytoma pattern

An Invasive Solitary Fibrous Tumor/Hemangiopericytoma Originating From the Falx: A Case Report

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