Intracranial tuberculomas: MRI signal intensity correlation with histopathology and localised proton spectroscopy

Gupta, Rakesh K.; Pandey, Rakesh; Khan, Enam Murshed; Mittal, Piyush; Gujral, R. B.; Chhabra, D. K.

doi:10.1016/0730-725x(93)90079-s

Cited by 103 publications

(40 citation statements)

References 13 publications

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“…With maturity, the lesions demonstrate hypointense areas and pathologically have solid caseation surrounded by cellular reaction. MR spectroscopy of tuberculomas has shown only lipid resonances and no choline peak (3,22,23). These spectra represent only the T2 hypointense solid caseation found in the center of mature tuberculomas, and the volume of interest in these reports is confined to this central caseating area.…”

Section: Discussionmentioning

confidence: 84%

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Spectroscopic increase in choline signal is a nonspecific marker for differentiation of infective/inflammatory from neoplastic lesions of the brain

Venkatesh

Gupta

Pal

et al. 2001

Magnetic Resonance Imaging

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We report in vivo proton magnetic resonance (MR) spectroscopic findings in three benign infective/inflammatory lesions (one case each of tuberculoma, fungal granuloma, and xanthogranuloma), which showed high choline along with the presence of lipid/lactate, a feature characteristically described in neoplastic lesions. Histopathology of the lesions showed inflammatory cellular infiltrates with areas of necrosis/caseation. The spectroscopic-visible increased choline resonance in these lesions is probably the result of cellularity. We conclude that increased choline, along with the presence of lipid/lactate is a nonspecific finding and may not be of much value in the differentiation of neoplastic from nonneoplastic infective/inflammatory intracranial mass lesions. J. Magn. Reson. Imaging 2001;14:8 -15.

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Section: Discussionmentioning

confidence: 84%

“…Tuberculomas are known to show varying imaging appearances, depending upon their maturity, cellular infiltrate, and fibrosis and gliosis (22). Initially, they have more cellular infiltrate, less or scanty macrophages, and minimal or no fibrosis and appear as hyperintense lesions on T2-weighted images.…”

Section: Discussionmentioning

confidence: 99%

Spectroscopic increase in choline signal is a nonspecific marker for differentiation of infective/inflammatory from neoplastic lesions of the brain

Venkatesh

Gupta

Pal

et al. 2001

Magnetic Resonance Imaging

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“…4,5,7,13,23,26 MRG ve difüzyon MRG'de TB lezyonlarına spesifik ve sensitiv değildir. [27][28][29][30] Solit kazeöz TB difüzyon MRG T1 ve T2 kesitlerinin her ikisinde de izo veya hiperintens sinyal olarak görülebilmekte, TB'nin evresine ve kazeifikasyonunun varlığına göre MRG bulguları da değişmektedir. 13,26,[30][31][32] F Fi in na an ns sa al l K Ka ay yn na ak k Bu çalışma sırasında, yapılan araştırma konusu ile ilgili doğru-dan bağlantısı bulunan herhangi bir ilaç firmasından, tıbbi alet, gereç ve malzeme sağlayan ve/veya üreten bir firma veya herhangi bir ticari firmadan, çalışmanın değerlendirme sürecinde, çalışma ile ilgili verilecek kararı olumsuz etkileyebilecek maddi ve/veya manevi herhangi bir destek alınmamıştır.…”

Section: Discussionunclassified

Miliary Tuberculosis With Cerebellar Involvoment

Köse¹,

Akkan²,

Topçuoğlu³

et al. 2018

Turkiye Klinikleri Arch Lung

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yılında, dünyada yaklaşık 10,4 milyon yeni tüberkü-loz (TB ) ve 480.000 yeni çok ilaça dirençli TB (ÇİD-TB) hasta sayıları ile; TB ciddi bir halk sağlığı sorunu olarak öne çıkmaktadır. Aynı yılda, 1,4 milyon kişinin TB nedeni ile öldüğü ve bu hastaların 340.000'inin ÇİD-TB tanılı olduğu hesaplanmıştır.1,2 Bu ne- A An na ah h t ta ar r K Ke e l li i m me e l le er

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“…The common differential diagnosis includes neurocysticercosis, malignant disease, sarcoidosis, pyogenic abscess and toxoplasmosis. 8 Although stereotactic biopsy is essential but in resource poor settings, it is usually avoided or unavailable.…”

Section: Discussionmentioning

confidence: 99%

Fever of unknown origin - Hidden in the head

et al. 2015

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The original algorithmic approach, as outlined by de Kleijn and colleagues and practiced commonly, envisages performing computed tomography (CT) of chest, abdomen, and pelvis in patients with classical fever of unknown origin (FUO), in whom no potentially diagnostic clue exists. It further envisages performing positron emission tomography (PET) scan, if CT scan is unrevealing. Imaging of head and neck especially magnetic resonance imaging (MRI) has not been included in this algorithm, that leaves these important regions unexplored in most settings where PET scan is unavailable. MRI is a safe modality for evaluating central nervous system lesions and its role in FUO has not been adequately evaluated. We present three patients of FUO in whom the diagnosis of tuberculoma of brain as a cause of prolonged pyrexia got delayed because the MRI of head was not done initially, to comply with the approach of minimum diagnostic evaluation.

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Intracranial tuberculomas: MRI signal intensity correlation with histopathology and localised proton spectroscopy

Cited by 103 publications

References 13 publications

Spectroscopic increase in choline signal is a nonspecific marker for differentiation of infective/inflammatory from neoplastic lesions of the brain

Spectroscopic increase in choline signal is a nonspecific marker for differentiation of infective/inflammatory from neoplastic lesions of the brain

Miliary Tuberculosis With Cerebellar Involvoment

Fever of unknown origin - Hidden in the head

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