Intracranial tumors in children: a 10-year review from a single tertiary health-care center

Riaz, Quratulain; Naeem, Ehsun; Fadoo, Zehra; Lohano, Mahadev; Mushtaq, Naureen

doi:10.1007/s00381-019-04260-7

Cited by 28 publications

(22 citation statements)

References 13 publications

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“…As a result of this twinning program, the number of referrals to AKUH and ICCH has increased tremendously. The number of cases seen per year at AKUH after the twinning program began in 2014 went up to 70 per year from 18 per year between 2004 and 2014 30 . This is similar to unpublished data from ICCH, which shows that 45 cases per year were managed between 2014 and 2019, up from 17 cases per year between 1998 and 2013.…”

Section: Discussionsupporting

confidence: 78%

“…One study from AKUH analyzed the outcome of 175 children with primary CNS tumors. Half (89) were lost to follow‐up (51%), and of the remaining 86 patients, 11.4% were alive with stable disease, 8.5% were alive with no recurrence, 5.1% had a recurrence, and 24% had not survived 30 …”

Section: Discussionmentioning

confidence: 99%

“…The number of cases seen per year at AKUH after the twinning program began in 2014 went up to 70 per year from 18 per year between 2004 and 2014. 30 stains, which are being validated and optimized. We believe these measures will enhance our capability to correctly diagnose CNS tumors and will result in less dependency on our twinning partner.…”

Section: Long-term Impactmentioning

confidence: 99%

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Building the ecosystem for pediatric neuro‐oncology care in Pakistan: Results of a 7‐year long twinning program between Canada and Pakistan

Mushtaq

Mustansir

Minhas

et al. 2022

Pediatric Blood & Cancer

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Background: Low-and middle-income countries sustain the majority of pediatric cancer burden, with significantly poorer survival rates compared to high-income countries.Collaboration between institutions in low-and middle-income countries and highincome countries is one of the ways to improve cancer outcomes.Methods: Patient characteristics and effects of a pediatric neuro-oncology twinning program between the Hospital for Sick Children in Toronto, Canada and several hospitals in Karachi, Pakistan over 7 years are described in this article.Results: A total of 460 patients were included in the study. The most common primary central nervous system tumors were low-grade gliomas (26.7%), followed by medulloblastomas (18%), high-grade gliomas (15%), ependymomas (11%), and craniopharyngiomas (11.7%). Changes to the proposed management plans were made in consultation with expert physicians from the Hospital for Sick Children in Toronto, Canada. On average, 24% of the discussed cases required a change in the original management plan over the course of the twinning program. However, a decreasing trend in change in management plans was observed, from 36% during the first 3.5 years to 16% in the last 3 years. This program also led to the launch of a national pediatric neuro-oncology telemedicine program in Pakistan.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Long-term Impactmentioning

confidence: 99%

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Building the ecosystem for pediatric neuro‐oncology care in Pakistan: Results of a 7‐year long twinning program between Canada and Pakistan

Mushtaq

Mustansir

Minhas

et al. 2022

Pediatric Blood & Cancer

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“…Among the 110 patients, there was a slight male predominance, with a ratio of 1.2:1, and there was no speci c location preference. Obviously, most astrocytomas belong to low grade tumors, which is consistent with previous research(El-Gaidi 2011, Riaz et al 2019, Shah et al 2015. Medulloblastoma, an embryonal tumor of the posterior fossa, comprises up to 20% of all pediatric brain tumors (Ostrom et al 2019, Shtil 2016).…”

Section: Discussionsupporting

confidence: 89%

Clinical and Epidemiological Study of Intracranial Tumors in Children and Identification of Diagnostic Biomarkers for the Most Common Tumor Subtype and Their Relationship With the Immune Microenvironment Through Bioinformatics Analysis

Wang

Jia

et al. 2022

Preprint

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Background: Brain tumors are the second most common pediatric malignancy and have poor prognosis. Understanding the pathogenesis of tumors at the molecular level is essential for clinical treatment. We conducted a retrospective study on the epidemiology of brain tumors in children based on clinical data obtained from a neurosurgical center. After identifying the most prevalent tumor subtype, we identified new potential diagnostic biomarkers through bioinformatics analysis of the public database. Methods: All children (0–15 years) with brain tumors diagnosed histopathologically between 2010 and 2020 at the Department of Neurosurgery, Xijing Hospital, were reviewed retrospectively for age distribution, sex predilection, native location, tumor location, symptoms, and histological grade, and identified the most common tumor subtypes. Two datasets (GSE44971 and GSE44684) were downloaded from the Gene Expression Omnibus database, whereas the GSE44971 dataset was used to screen the differentially expressed genes between normal and tumor samples. Gene Ontology, Disease Ontology, and Gene Set Enrichment Analysis enrichment analyses were performed to investigate the underlying mechanisms of differentially expressed genes in the tumor. Combined with methylation data in the GSE44684 dataset, we further analyzed the correlation between methylation and gene expression levels. Two algorithms, LASSO and SVM-RFE, were used to select the hub genes of the tumor. The diagnostic value of the hub genes was assessed using the receiver operating characteristic (ROC) curve. Finally, we further evaluated the relationship between the hub gene and the tumor microenvironment and immune gene sets. Results: Overall, 650 children from 18 provinces in China were included in this study. The male-to-female ratio was 1.41:1, and the number of patients reached a peak in the 10-15-year-old group (41.4%).The most common symptoms we encountered in our institute were headache and dizziness 250 (28.2%), and nausea and vomiting 228 (25.7%). The predominant location is supratentorial, with a supratentorial to infratentorial ratio of 1.74:1. Low-grade tumors (WHO I/II) constituted 60.9% of all cases and were predominant in every age group. According to basic classification, the most common tumor subtype is pilocytic astrocytoma (PA). A total of 3264 differentially expressed genes were identified in the GSE44971 dataset, which are mainly involved in the process of neural signal transduction, immunity, and some diseases. Correlation analysis indicated that the expression of 45 differentially expressed genes was negatively correlated with promoter DNA methylation. Next, we acquired five hub genes (NCKAP1L, GPR37L1, CSPG4, PPFIA4, and C8orf46) from the 45 differentially expressed genes by intersecting the LASSO and SVM-RFE models. The ROC analysis revealed that the five hub genes had good diagnostic value for patients with PA (AUC > 0.99). Furthermore, the expression of NCKAP1L was negatively correlated with immune, stromal, and estimated scores, and positively correlated with immune gene sets.Conclusions: This study, based on the data analysis of intracranial tumors in children in a single center over the past 10 years, reflected the clinical and epidemiological characteristics of intracranial tumors in children in Northwest China to a certain extent. PA is considered the most common subtype of intracranial tumors in children. Through bioinformatics analysis, we suggested that NCKAP1L, GPR37L1, CSPG4, PPFIA4, and C8orf46 are potential biomarkers for the diagnosis of PA.

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“…Study carried out by Riaz et al, brain tumors in pediatric population identifying male preponderance with a male to female ratio 1.4:1 17 . Our inclusion criteria had age range starting from 3 years, though youngest patient was 26 years of age.…”

Section: Discussionmentioning

confidence: 99%

Experience of Brain Tumors in Tertiary Care Hospital

Shah¹,

Ishfaq²,

Malik³

et al. 2022

PJMHS

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Background: Brain tumors arising in the brain are called primary brain tumors. The brain tumors could be meninges, glands, nerves or brain tissue. Although brain tumors comprise of a small number of all cancers, but are disproportionately responsible for cancer-related deaths. The neoplasms may be low grade, high grade, primary tumor or metastatic. Aim: To evaluate the experience of brain tumors in a tertiary care hospital. Place and duration of study: Department of Neurosurgery, CMH, Lahore from March 2021 to March 2022. Methodology: This descriptive study included 38 patients. Age of patients ranged between 26 to 70 years and both genders having primary and secondary (metastatic) brain tumors who were considered fit for surgery were included. Patients who were unfit for anesthesia or unwilling for operation were excluded. Diagnosis of brain tumors was made by histopathology. Results: Mean age was 46.18±12.17 years. Male patients were 25(65.8%) and 13(34.2%) were female. All patients 38(100%) had headache 31(82%) patient had seizures, focal weakness in 26(68.42%) patients and 3(7.89%) patients had urinary/fecal incontinence. Majority of patients 16(42.11%) had glioblastoma, meningioma in 8(21.05%) patients while 3(7.89%) patients had pituitary adenoma. 15(39.47%) patients had tumor in right frontal lobe, 8(21.05%) patients in left parietal lobe and 4(10.52%) patients had tumor in right parietal lobe. Out of 3 patients, 1(2.63%) had right CP angle tumor, 1(2.63%) had in sphenoid ridge tumor, 1(2.63%) had tumor in Tuberculum Sallea respectively. Conclusion: It is concluded that male population had more brain tumor and glioblastomawas the most common tumor. Keywords: Brain tumors, Headache, Glioblastoma, Meningioma.

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Intracranial tumors in children: a 10-year review from a single tertiary health-care center

Cited by 28 publications

References 13 publications

Building the ecosystem for pediatric neuro‐oncology care in Pakistan: Results of a 7‐year long twinning program between Canada and Pakistan

Building the ecosystem for pediatric neuro‐oncology care in Pakistan: Results of a 7‐year long twinning program between Canada and Pakistan

Clinical and Epidemiological Study of Intracranial Tumors in Children and Identification of Diagnostic Biomarkers for the Most Common Tumor Subtype and Their Relationship With the Immune Microenvironment Through Bioinformatics Analysis

Experience of Brain Tumors in Tertiary Care Hospital

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