Intracranial Venous Thrombosis as Complication of Oral Contraception

Atkinson, E. A.; Fairburn, B; Heathfield, K. W. G.

doi:10.1016/s0140-6736(70)91046-9

Cited by 63 publications

(20 citation statements)

References 8 publications

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“…The literature contains a number of cases of dural venous thrombosis and cerebral infarction in women receiving oral contraceptive agents. 1 In another group of cases, of increasing significance, cerebral venous thrombosis with infarction has been observed in patients treated for prolonged periods in the respirator. 23 This complication is associated clinically with the syndrome commonly known as "brain death.…”

Section: Stroke Vol 4 May-june 1973mentioning

confidence: 97%

The Syndrome of Latent Cerebral Venous Thrombosis: Its Frequency and Relation to Age and Congestive Heart Failure

Towbin

1973

Stroke

105

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The present investigation indicates the high incidence of intracranial venous thrombosis in adults in the older age groups, especially in the female. Commonly overlooked clinically and pathologically, cerebral venous thrombosis is usually preceded congestive circulatory failure and other related systemic disturbances. Most patients with venous thrombosis intracranially also develop thromboembolic complications at other sites in the body. Although often latent clinically, concurrent pulmonary embolism (as revealed in postmortem studies) occurs in a majority of patients with cerebral venous thrombosis. With clinical and pathological aspects of the process correlated, cerebral venous thrombosis in the aged presents a characteristic pattern. In some cases, in patients with enigmatic progressive coma and neurological deterioration, cerebral venous thrombosis occurs as the primary cause of death. In other instances, in patients with cardiac disease or other major systemic disorders, intracranial venous thrombosis develops as a terminal complication leading to death. Cerebral venous thrombosis is of increasing incidence. There is an expressed need that this form of stroke be more widely recognized clinically.

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Section: Stroke Vol 4 May-june 1973mentioning

confidence: 97%

The Syndrome of Latent Cerebral Venous Thrombosis: Its Frequency and Relation to Age and Congestive Heart Failure

Towbin

1973

Stroke

105

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“…Many of the abnormalities may be related to increased intracranial pressure due to decreased cerebrospinal fluid absorption secondary to venous hypertension. Others can be attributed to intracranial venous hemorrhage [9,10,12). An often forgotten complication of sinus thrombosis is pulmonary embolism, of which Diaz and coauthors [6] stated there were 23 cases in the literature between 1942 and 1990.…”

Section: Patientmentioning

confidence: 99%

Treatment of dural sinus thrombosis using selective catheterization and urokinase

Horowitz

Purdy

Unwin

et al. 1995

Annals of Neurology

221

110

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Thrombosis of the cerebral dural venous sinuses, cortical draining veins, and deep cerebral veins is a rare clinical finding. Because of its low incidence and multiple etiologies, the optimum therapy for this condition will only be elucidated by a multicenter, randomized prospective study. At our institution, we favor early and aggressive management of cerebral venous sinus thrombosis with transfemoral, venous intradural infusions of the fibrinolytic agent urokinase. To date, treatment of only 13 patients using this technique has been reported in the English literature. This report adds 12 more such treated patients. Despite the presence of preinfusion infarcts in 5 patients, four of which were hemorrhagic, we incurred no major therapeutic morbidity. Functional sinus patency was achieved in 11 of 12 patients, with our only true failure occurring in an individual with symptoms of at least 2 months' duration. Good to excellent clinical outcome was achieved in 10 of 11 patients (one newborn had inadequate follow-up).

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“…Seventeen patients recovered, 2 had previously realized. 20 It is recognized as occurring most often in women taking oral contraceptives, 1 ' ''•• " during the immediate post-partum period, during pregnancy, 1216 - 19 ' 22 and in elderly patients with congestive heart failure. 20 Marantic or non-infectious sinus thrombosis also occurs as a complication of malnutrition, sepsis, systemic tuberculosis, congenital heart disease, secondary and primary polycythemia, dehydration, closed head injuries, leukemia, postoperative states, shock, diabetic keto-acidosis, disseminated intravascular coagulation of various causes and paroxysmal nocturnal hemoglobinuria.…”

Section: Treatmentmentioning

confidence: 99%

Intracranial venous thrombosis in young women.

Estañol¹,

Rodriguez²,

Conte³

et al. 1979

Stroke

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SUMMARY Twenty women of child-bearing age with intracraniai venous thrombosis are reported. Thirteen developed thrombosis post-partum; 6 while on oral contraceptives. In one patient no cause was found. All diagnoses were confirmed by carotid angiography and in 10 out of 14 patients laboratory data indicated a hypercoagulable state. Coagulation studies were performed in 14 normal puerperal women, matched by age, who served as controls. No statistical differences was found between thrombotic and control groups. Radiologic signs of sino-venous occlusion are reviewed. Conservative treatment with anti-edematous agents, anticonvulsants and antiplatelet aggregants is advocated.

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Intracranial Venous Thrombosis as Complication of Oral Contraception

Cited by 63 publications

References 8 publications

The Syndrome of Latent Cerebral Venous Thrombosis: Its Frequency and Relation to Age and Congestive Heart Failure

The Syndrome of Latent Cerebral Venous Thrombosis: Its Frequency and Relation to Age and Congestive Heart Failure

Treatment of dural sinus thrombosis using selective catheterization and urokinase

Intracranial venous thrombosis in young women.

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