Intracranial venous thrombosis complicating oral contraception: treatment by anticoagulant drugs.

Fairburn, B

doi:10.1136/bmj.2.5867.647

Cited by 49 publications

(17 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Krayenbuhl 15 has given anticoagulants to 17 patients apparently without complications. Fairburn 16 reported 2 patients treated with heparin. He believed this therapy arrested progression of the illness and recommended it.…”

mentioning

confidence: 99%

Intracranial venous thrombosis in young women.

Estañol¹,

Rodriguez²,

Conte³

et al. 1979

Stroke

View full text Add to dashboard Cite

SUMMARY Twenty women of child-bearing age with intracraniai venous thrombosis are reported. Thirteen developed thrombosis post-partum; 6 while on oral contraceptives. In one patient no cause was found. All diagnoses were confirmed by carotid angiography and in 10 out of 14 patients laboratory data indicated a hypercoagulable state. Coagulation studies were performed in 14 normal puerperal women, matched by age, who served as controls. No statistical differences was found between thrombotic and control groups. Radiologic signs of sino-venous occlusion are reviewed. Conservative treatment with anti-edematous agents, anticonvulsants and antiplatelet aggregants is advocated.

show abstract

mentioning

confidence: 99%

Intracranial venous thrombosis in young women.

Estañol¹,

Rodriguez²,

Conte³

et al. 1979

Stroke

View full text Add to dashboard Cite

show abstract

“…17 The only therapeutic conclusion that can be drawn from the present study is that anticoagulants were not harmful since among the 23 heparin treated patients, there was not a single death and 19 made a complete recovery. Furthermore, the dramatic improvement seen in 3 patients just after initiation of heparin does suggest that anticoagulants may be beneficial; 9 -l0 ' 28 this seemed to be the case even in the patient who had a CT scan suggestive of an hemorrhagic infarct.…”

mentioning

confidence: 99%

Cerebral venous thrombosis--a review of 38 cases.

Bousser¹,

Chiras²,

Bories³

et al. 1985

Stroke

685

420

View full text Add to dashboard Cite

199SUMMARY A series of 38 patients with angiographically proven cerebral venous thrombosis (CVT) affecting dural sinuses is reported. This study shows that CVT is not rare, that the clinical diagnosis is extremely difficult because of the variable modes of onset and groupings of symptoms, that most CT findings are non specific and that angiography remains the best diagnostic tool. Only 4 patients died, which suggests a more benign outcome than classically described. None of the 23 heparin treated patients died, which indicates that anticoagulants were not harmful in this series.

show abstract

“…Hypercoagulability ap peared to be the final common pathway of all of the risk factors that were found, but this is to be expected when one is studying nonseptic, nontraumatic SSST. The cor relation of pregnancy, the puerperium, malignancy and oral contraceptive pills with SSST has been shown in several previous studies [1][2][3][4][5][6], but the association with the 'lupus anticoagulant' has only been shown in one previous study by Levine et al [7], We recommend searching for the 'lupus anticoagulant' when no other eti ology of SSST is identified.…”

Section: Discussionmentioning

confidence: 99%

“…Gettelfinger and Kokmen [8] concluded that anticoagulants should not be used and that 'one should rely on antiedematous agents and anticonvulsants' after 2 of their 3 patients who received anticoagulants died of hemor rhagic intracranial complications. Several other groups have had similar experiences and therefore have reserva tions about using anticoagulants in the treatment of SSST [2,3,9], Other investigators recommend anticoag ulants for the treatment of SSST, ostensibly to prevent extension of thrombosis and to allow the development of collateral circulation [1,4,5,[10][11][12][13], Di Rocco et al [6] used a combination of heparin and urokinase in 5 patients with complete clinical recovery in all. By per forming pre-and posttherapy angiograms, they demon strated resolution of cerebral sinus thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Outcome in Nonseptic Spontaneous Superior Sagittal Sinus Thrombosis in Adults

Kaplan¹,

Biller²,

Adams³

1991

Cerebrovasc Dis

View full text Add to dashboard Cite

We reviewed clinical features and outcomes of 16 patients (3 men and 13 women) aged 18–68 years, with nonseptic, nontraumatic superior sagittal sinus thrombosis (SSST). Most common risk factors were oral contraceptives, a postpartum state or malignancy. Two patients were noted to have a ‘lupus anticoagulant’; 1 of these had prior venous thrombosis in the legs and recurrent spontaneous abortions but no antiphospholipid antibodies. Five patients had ;poor outcomes, including 4 deaths. Of the 11 patients with good outcomes, 9 had no residual deficits. Intracranial hemorrhage was noted on initial CT in 3 patients. One had hemorrhagic transformation of a bland cerebral infarction without use of anticoagulants, as did 1 after receiving only 1,600 IU of intravenous heparin. Of the 11 patients who had a good outcome, 5 received full-dose intravenous heparin. Of the 5 patients who had a poor outcome, none received full-dose heparin due to the presence of either a large infarction or hemorrhage. Due to its infrequent occurrence and heterogenous nature, recommendations regarding heparin therapy for patients with nonseptic SSST should be individualized.

show abstract

Intracranial venous thrombosis complicating oral contraception: treatment by anticoagulant drugs.

Cited by 49 publications

References 6 publications

Intracranial venous thrombosis in young women.

Intracranial venous thrombosis in young women.

Cerebral venous thrombosis--a review of 38 cases.

Outcome in Nonseptic Spontaneous Superior Sagittal Sinus Thrombosis in Adults

Contact Info

Product

Resources

About