Intracranial vessel wall lesions in patients with systematic lupus erythematosus

Ide, Satoru; Kakeda, Shingo; Miyata, Mari; Iwata, S.; Ohkubo, Naoaki; Nakayamada, Shingo; Futatsuya, Koichiro; Watanabe, Keita; Moriya, Junji; Fujino, Yoshihisa; Korogi, Yukunori

doi:10.1002/jmri.25966

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…21 A recent study analyzed the vessel-wall imaging at 3 Tesla MRI in a cohort of SLE patients, and compared the data with a group of healthy controls. 22 They demonstrated different types of vessel-wall focal lesions, more frequent in SLE group, particularly of the first segments of the middle cerebral artery. Moreover, vessel-wall lesions were associated with brain infarctions.…”

Section: Discussionmentioning

confidence: 95%

Fulminant Brain Atrophy and Vasculitis on Vessel-Wall Imaging in Neuropsychiatric Lupus: Case Report and Literature Review

Sârbu

2020

Arch Rheumatol

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Brain atrophy is a hallmark of neuropsychiatric (NP) systemic lupus erythematosus (SLE), and probably the most important magnetic resonance imaging (MRI) biomarker for the diagnosis and prognosis of NPSLE. 1,2 Atrophy in NPSLE is typically slowly progressive, over several years. Brain atrophy could be diffuse or could involve preferentially the fronto-temporal regions, with symmetrical involvement of gray and white matter. Underlying mechanisms of atrophy are not well understood, commonly incriminated factors being long-standing disease, activity and injury scores

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Section: Discussionmentioning

confidence: 95%

Fulminant Brain Atrophy and Vasculitis on Vessel-Wall Imaging in Neuropsychiatric Lupus: Case Report and Literature Review

Sârbu

2020

Arch Rheumatol

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“…11 MRI is the most sensitive noninvasive imaging test for cerebral large-vessel vasculitis, with certain special sequences capable of revealing wall-thickening and intramural contrast material uptake in arteries. 12,13 Central nervous sysytem vasculitis typically demonstrates multifocal, segmental, smooth, concentric enhancement and thickening of the vessel walls on HRMR-VWI. [14][15][16][17] This is thought to be caused by hyperpermeability of the endothelium and/or neovascularization, which results in leakage of contrast into the arterial wall from the lumen of the main vessel or from vasa vasorum.…”

Section: Discussionmentioning

confidence: 99%

“…Using neuroimaging in conjunction with clinical features can often lead to early diagnosis without the need for a brain biopsy 11 . MRI is the most sensitive noninvasive imaging test for cerebral large-vessel vasculitis, with certain special sequences capable of revealing wall-thickening and intramural contrast material uptake in arteries 12,13 . Central nervous sysytem vasculitis typically demonstrates multifocal, segmental, smooth, concentric enhancement and thickening of the vessel walls on HRMR-VWI 14–17 .…”

Section: Discussionmentioning

confidence: 99%

A Case of Cerebral Large-Vessel Vasculitis Concomitant Fahr Syndrome in Systemic Lupus Erythematosus

Jiang,

Mei,

Deng

et al. 2023

The Neurologist

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Introduction: Systemic lupus erythematosus (SLE) is a heterogenous, devastating autoimmune inflammatory disease with multiorgan involvement. A variety of neurological and psychiatric symptoms may be caused by nervous system involvement, termed neuropsychiatric systemic lupus erythematosus. Case Report: We describe a young man newly diagnosed with SLE who had a stroke as an initial symptom and was found to have cerebral large-vessel vasculitis and Fahr syndrome. Conclusions: The novelties of this report are the extensive cerebral calcification demonstrated on head computerized tomography in a patient with SLE, and the depiction of an underlying vasculitis on high-resolution magnetic resonance vessel wall imaging. It is our aim to describe this atypical form of neuropsychiatric systemic lupus erythematosus onset and to make known the usefulness of the new magnetic resonance imaging techniques for the diagnosis of cerebral large-vessel vasculitis.

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“…4 Due of the difficulty of performing postmortem brain biopsy, the pathology of large-vessel vasculitis in SLE patients has not been established. 5 However, the mortality rate in patients with large-vessel vasculitis is extremely high (approximately 67%). To prevent fatal outcomes, immediate diagnosis and aggressive immunosuppressive treatment are needed.…”

Section: Discussionmentioning

confidence: 99%

Acute Stroke Caused by Large Vessel Vasculitis in a Patient with Systemic Lupus Erythematosus

Lee

Hwang

Lee

et al. 2022

J Neurosonol Neuroimag

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Systemic lupus erythematosus is an uncommon cause of ischemic stroke. The subcortical and periventricular white matter are most commonly involved in the central nervous system. Although vasculitis is the most frequently mentioned etiology of stroke, it has been mainly documented in the vicinity of small-diameter vessels. In the present case, we report a young women with lupus nephritis who presented with stroke caused by large-vessel vasculitis, which was confirmed by vessel wall magnetic resonance imaging.

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Intracranial vessel wall lesions in patients with systematic lupus erythematosus

Abstract: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1237-1246.

Cited by 14 publications

References 33 publications

Fulminant Brain Atrophy and Vasculitis on Vessel-Wall Imaging in Neuropsychiatric Lupus: Case Report and Literature Review

Fulminant Brain Atrophy and Vasculitis on Vessel-Wall Imaging in Neuropsychiatric Lupus: Case Report and Literature Review

A Case of Cerebral Large-Vessel Vasculitis Concomitant Fahr Syndrome in Systemic Lupus Erythematosus

Acute Stroke Caused by Large Vessel Vasculitis in a Patient with Systemic Lupus Erythematosus

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