Intracranial Vessel Wall Magnetic Resonance Imaging Does Not Allow for Accurate and Precise Wall Thickness Measurements

Hespen, Kees M. van; Zwanenburg, Jaco J.M.; Harteveld, Anita A.; Luijten, Peter R.; Hendrikse, Jeroen; Kuijf, Hugo J.

doi:10.1161/strokeaha.119.026497

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…Various attempts using high-field and ultra-high-field MRI addressed non-invasive vessel wall imaging of intracranial cerebral arteries in vivo [ 23 , 24 ]. So far, spatial resolution remains limited with voxel sizes of 500–800 μm inhibiting a detailed depiction of vessel wall composition [ 25 ]. As an intraoperative real-time imaging method ultra sound states the gold standard and is integrated in daily clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Extravascular optical coherence tomography of cerebral vessel walls in vivo

et al. 2023

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Purpose Evaluation of extravascular, microscope integrated OCT (iOCT) as an in vivo imaging modality of cerebral blood vessels and as an intraoperative imaging method. Methods Microscope integrated optical coherence tomography of major cerebral arteries (n = 13) and superficial sylvian veins (n = 5) and one incidental cerebral vasospasm (n = 1) in (n = 10) patients. Post procedural analysis of OCT volume scans, microscopic images and videos during the time of scan as well as measurements of the diameter of vessel walls and its layers with an accuracy of 7.5 μm. Results iOCT was feasible during vascular microsurgical procedures. In all scanned arteries a clear delineation of the physiological three layered vessel wall composition could be achieved. Pathological arteriosclerotic alterations of cerebral artery walls could precisely be demonstrated. Major superficial cortical veins conversely presented a mono layered composition. First in vivo measurements of vascular mean diameters were possible. Cerebral artery walls showed a diameter of 296 μm, tunica externa 78 μm, media 134 μm and interna 84 μm. Conclusion For the first time the microstructural composition of cerebral blood vessels could be illustrated in vivo. Due to an outstanding spatial resolution a clear definition of physiological and pathological characteristics was possible. Therefore, microscope integrated optical coherence tomography holds promise for basic research in the field of cerebrovascular arteriosclerotic diseases and for intraoperative guidance during microvascular surgery.

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Section: Discussionmentioning

confidence: 99%

Extravascular optical coherence tomography of cerebral vessel walls in vivo

et al. 2023

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“…However, most vessel wall lesions encountered in our populations, Caucasian subjects, which Alexander et al justly noted were not specifically mentioned in our article, are too small to accurately measure, let alone characterize, apart from the presence or absence of enhancement. 2 It would indeed also have been of interest to correlate vessel wall lesion locations with cerebrovascular symptoms, but this would necessitate a different study population-with more (cerebrovascular) symptomatic patients-to reach any statistically significant results.…”

Section: Replymentioning

confidence: 99%

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Zwartbol¹,

Kolk²,

Geerlings

2020

AJNR Am J Neuroradiol

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“…Measurements of post-mortem specimens of the circle of Willis imaged with clinical VW-MRI acquisitions showed that wall thickness measurements are neither accurate nor precise for walls thinner than 1.0 mm. 34 The vast majority of ruptured aneurysms show wall enhancement on imaging. This enhancement is hypothesized to result from inflammation within the wall preceding and leading to the rupture, from a hemostatic thrombus at the rupture site, or from physical leakage of contrast medium from the aneurysm lumen secondary to endothelial disruption.…”

Section: Histopathologic Correlates Of Awementioning

confidence: 99%

Vessel wall magnetic resonance imaging in intracranial aneurysms: Principles and emerging clinical applications

et al. 2019

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Intracranial high-resolution vessel wall magnetic resonance imaging is an imaging paradigm that complements conventional imaging modalities used in the evaluation of neurovascular pathology. This review focuses on the emerging utility of vessel wall magnetic resonance imaging in the characterization of intracranial aneurysms. We first discuss the technical principles of vessel wall magnetic resonance imaging highlighting methods to determine aneurysm wall enhancement and how to avoid common interpretive pitfalls. We then review its clinical application in the characterization of ruptured and unruptured intracranial aneurysms, in particular, the emergence of aneurysm wall enhancement as a biomarker of aneurysm instability. We offer our perspective from a high-volume neurovascular center where vessel wall magnetic resonance imaging is in routine clinical use.

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Intracranial Vessel Wall Magnetic Resonance Imaging Does Not Allow for Accurate and Precise Wall Thickness Measurements

Cited by 9 publications

References 4 publications

Extravascular optical coherence tomography of cerebral vessel walls in vivo

Extravascular optical coherence tomography of cerebral vessel walls in vivo

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Vessel wall magnetic resonance imaging in intracranial aneurysms: Principles and emerging clinical applications

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