Intracranial white epidermoid cyst with dystrophic calcification – A case report and literature review

Ravindran, Krishnan; Rogers, Te Whiti; Yuen, Tanya; Gaillard, Frank

doi:10.1016/j.jocn.2017.03.006

Cited by 19 publications

(14 citation statements)

References 14 publications

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“…Magnetic resonance imaging findings include variable intensity on T1-weighted images, and hyperintensity on fluid-attenuated inversion recovery (FLAIR) and T2-weighted images. 1,4,6,10,15,17,19,20 On gross, sellar ECs are a pale-gray, uniloculated, translucent lesion, which can measure from a few millimeters to over 4 cm in diameter. 1,4,6,9,15,16,21,22 At microscopy, ECs are covered by a mature keratinizing squamous epithelium, and the lumen is occupied by lamellae of keratin.…”

Section: Discussionmentioning

confidence: 99%

“…Sellar EC shows positive immunoexpression for keratins and negative pattern for glial fibrillary acidic protein (GFAP) and synaptophysin. 1,4,6,9,15,20,22 In the sellar/suprasellar region, the differential diagnosis of EC includes dermoid cysts, craniopharyngioma, enterogenous cyst, neuroglial cyst, arachnoid cysts, endodermal cyst, Rathke cleft cyst with extensive squamous metaplasia, eventually metastatic well differentiated squamous cell carcinoma, and mature teratoma. [4][5][6]9,11,15,20,23,24 Dermoid cysts (DCs) arise more commonly in the midline of infants, being related to fontanel, the fourth ventricle, or the spinal canal.…”

Section: Discussionmentioning

confidence: 99%

“…The process corresponds to $ 0.2 to 1.8% of all primary intracranial tumors and are 4 to 9 times as common as dermoid cysts. [1][2][3][4] Most ECs compromising the central nervous system (CNS) are extraaxial, leptomeningeal lesions, with the cerebellopontine angle (40-50% of patients) being the most common location. Epidermoid cysts can also be found in the 4 th ventricle (17%), in the sellar/parasellar region (10-15%), in the cerebral hemispheres, in the brainstem, in the skull, and in the spine.…”

Section: Introductionmentioning

confidence: 99%

“…Epidermoid cysts can also be found in the 4 th ventricle (17%), in the sellar/parasellar region (10-15%), in the cerebral hemispheres, in the brainstem, in the skull, and in the spine. [1][2][3][4][5][6] Most tumoral and non-tumoral sellar lesions are solid process, and pituitary adenoma is the most common tumor in this topography. Cystic sellar lesions are not as frequent as pituitary adenoma, and Rathke cysts and craniopharyngioma are usually the final diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…They have an excellent long-term survival, and gross total resection is usually curative. 1,2,[8][9][10][11] The authors describe a case of sellar EC presenting endocrine alterations and progressive visual disturbance in a 35 years female patient, and discuss the most common physiopathological findings of this lesion, and its differential diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Physiopathological Aspects of Sellar Epidermoid Cyst Determining Endocrine Disturbances: A Case Report

et al. 2019

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Epidermoid cysts (ECs) of the central nervous system (CNS) constitute benign circumscribed lesions that are more common in lateral than in midline sites. Epidermoid cysts of the CNS arise more frequently in the cerebellopontine angle, around the pons, near the sella, within the temporal lobe, in the diploe, and in the spinal canal. Most common tumoral lesion of sellar region is pituitary adenoma, and sellar cystic epithelial masses may be difficult to differentiate based only on clinical and imaging findings. Epidermoid cysts are covered by keratinized squamous epithelium and are usually filled with keratin lamellae. The process is, for the most part, maldevelopmental in origin, presumably arising from trapped surface ectodermal elements in association with the developing CNS during the closure of the neural groove or formation of the secondary cerebral vesicles. In the present study, the authors describe a case of sellar epidermoid cyst producing endocrine alterations and visual disturbance in a 35 years woman, and review the physiopathological and diagnostic criteria of this lesion.

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