Intracranial “white” epidermoid tumours – An imaging approach and systematic review

Loy, Liang Meng; Aftab, Syed; Ang, Ya Lyn Samantha; Ding, Szu Lyn Cristine; Ho, Chi Long

doi:10.1016/j.clinimag.2022.08.002

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…Thus, based on intraoperative findings and previous literature, we speculated that the high signal on T1WI is mainly related to the high protein content in the cyst, while the low signal on T2WI may be explained by the high viscosity of the cyst contents. According to the previous literature, intracranial epidermoid cysts demonstrate an markedly hyperintense signal compared to brain tissue and CSF on DWI because of the combination of T2 and diffusion effects, especially the T2 penetration effect rather than diffusion effects when ADC values were significantly higher than other brain area [13] , [14] . It can be inferred that the low signal on T2WI of the epidermoid cyst in this case resulted in the low signal on DWI.…”

Section: Discussionmentioning

confidence: 94%

“…Rare causes, such as the presence of melanin deposits, large numbers of polymorphonuclear leukocytes and infection, were also thought to be causes of atypical imaging findings [6] , [12] . The latest research suggested that HIECs contenting high protein levels and viscosity resulted in low T2 signal, while blood products resulted in high T2 signal [13] .…”

Section: Discussionmentioning

confidence: 99%

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Parasellar epidermoid cyst with unique radiological features: A case report and review of the literature

Wang¹,

Liu²,

Rayamajhi³

et al. 2023

Radiology Case Reports

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Parasellar epidermoid cyst with unique radiological features: A case report and review of the literature

Wang¹,

Liu²,

Rayamajhi³

et al. 2023

Radiology Case Reports

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“…Although tissue biopsy and conventional imaging techniques have been widely used for many years, limitations remain unaddressed. For tissue biopsy, limited sampling is often hard to capture the heterogeneity and evolution of tumors (Cheng et al, 2019), while conventional imaging techniques are less sensitive for the early detection of cancer (Loy et al, 2022). In recent years, liquid biopsy, which aims to provide an alternative to invasive tissue biopsy Frontiers in Genetics frontiersin.org by analyzing biomarkers in biofluids that reflect the nature of cancer (Ignatiadis et al, 2021), has been widely investigated.…”

Section: Discussionmentioning

confidence: 99%

Comparative analyses of salivary exosomal miRNAs for patients with or without lung cancer

Liu,

Yu,

et al. 2023

Front. Genet.

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Introduction: Lung cancer is the most frequent cause of cancer-related deaths worldwide. Exosomes are involved in different types of cancer, including lung cancer.Methods: We collected saliva from patients with (LC) or without (NC) lung cancer and successfully isolated salivary exosomes by ultracentrifugation. MiRNA sequencing was implemented for the exosome samples from NC and LC groups, dgeR was used to determine differentially expressed miRNAs (DE miRNAs), and quantitative real-time polymerase chain reaction (qPCR) was used to verify three differentially expressed microRNAs (miRNAs).Results: A total of 372 miRNAs were identified based on the sequencing results. Subsequently, 15 DE miRNAs were identified in LC vs. NC, including eight upregulated miRNAs and seven downregulated miRNAs. Some DE miRNAs were validated via qPCR. A total of 488 putative target genes of the upregulated DE miRNAs were found, and the functional analyses indicated that numerous target genes were enriched in the pathways associated with cancer.Discussion: This suggests that miRNAs of salivary exosomes might have the potential to be used as biomarkers for prediction and diagnosis of lung cancer.

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“…Intracranial epidermoid cysts (ECs) arise from ectodermal cells that become aberrantly trapped within the central nervous system during development. 1 They comprise approximately 1% of all intracranial cysts. 2 ECs are characterized by a thin epithelialized capsule and grow through the process of desquamation.…”

mentioning

confidence: 99%

Strangulation of the abducens nerve by an arachnoid band within an epidermoid cyst: illustrative case

Kosarchuk,

Patel,

Dent

et al. 2023

Journal of Neurosurgery: Case Lessons

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BACKGROUND Intracranial epidermoid cysts (ECs) are rare benign lesions of ectodermal origin that can be found in the cerebellopontine angle (CPA). If large enough, they compress surrounding structures, causing cranial neuropathies, cerebellar dysfunction, and hydrocephalus. OBSERVATIONS In this case report, the authors present a patient with headaches and diplopia secondary to a CPA EC. The cyst had wrapped itself around and was strangulating the abducens nerve. This choking of the nerve was believed to have been the cause of the patient’s double vision. The arachnoid band was released with a myringotomy knife. LESSONS Intracranial ECs typically cause symptoms from mass effect on surrounding structures; it is unusual for one to have choked off the nerve in the fashion presented in this case. Knowledge of the potential ways that ECs can affect nervous structures is critical for resecting them without injuring normal tissue.

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Intracranial “white” epidermoid tumours – An imaging approach and systematic review

Cited by 5 publications

References 22 publications

Parasellar epidermoid cyst with unique radiological features: A case report and review of the literature

Parasellar epidermoid cyst with unique radiological features: A case report and review of the literature

Comparative analyses of salivary exosomal miRNAs for patients with or without lung cancer

Strangulation of the abducens nerve by an arachnoid band within an epidermoid cyst: illustrative case

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