Intractable cough in a preterm infant with ventriculoperitoneal shunt

Bar‐Yoseph, Ronen; Livnat, Galit; Guilburd, Joseph N.; Vachyan, Arcady; Ilivitzky, Anat; Bentur, Lea

doi:10.1002/ppul.22596

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Because of the history of congenital hydrocephalus and ventriculoperitoneal shunting, abdominal X-ray was performed, as dislocation of catheter is reported to cause subdiaphragmatic irritation and cough that undergoes remission after correction of the catheter position [21]. In our patient, there were no radiological data on catheter dislocation.…”

Section: Discussionmentioning

confidence: 80%

Tic Cough in an Adolescent with Organic Brain Pathology—A Case Report and Literature Review

Grinevica,

Udre,

Balodis

et al. 2024

Brain Sciences

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Chronic cough in children and adolescents can be troublesome both to the patient and the whole family. The most common causes of chronic cough in children are protracted bacterial bronchitis and bronchial asthma. However, differential diagnostic workup and treatment can become complicated when a cough of different etiology is encountered, especially in a child having a complex medical history for an unrelated pathology. A cough lacking any identified somatic cause and response to medical treatment in combination with core clinical features of tics that include suppressibility, distractibility, suggestibility, variability, and the presence of a premonitory sensation is labeled tic cough. Here we discuss a case of an adolescent who had atrophy of the corpus callosum and a history of ventriculoperitoneal shunting due to hydrocephalus caused by stenosis of the sylvian aqueduct, but now presented with a debilitating dry cough lasting for several months. After physical causes of cough were ruled out, the diagnosis of tic cough was reached, and multidisciplinary treatment ensured complete recovery. To the best of our knowledge, this is the first reported case showing coincidence of tic cough and hydrocephalus. The co-occurrence of non-syndromic corpus callosum atrophy and tic cough might hypothetically suggest a predisposing pathogenetic link via reduced signaling through cortical inhibitory neurons; further studies are needed. The importance of careful assessment of medical history, clinical picture, and features of the cough itself are emphasized in order to reach the correct diagnosis. Increased awareness of medical society is mandatory to recognize tic cough and to distinguish it from the neurologic manifestations of organic brain pathology.

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Section: Discussionmentioning

confidence: 80%

Tic Cough in an Adolescent with Organic Brain Pathology—A Case Report and Literature Review

Grinevica,

Udre,

Balodis

et al. 2024

Brain Sciences

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Clinical Mechanism of the Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor in G551D-mediated Cystic Fibrosis

Rowe

Heltshe

Gonska

et al. 2014

Am J Respir Crit Care Med

453

429

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Rationale: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator recently approved for patients with CF age 6 and older with the G551D mutation.Objectives: To evaluate ivacaftor in a postapproval setting and determine mechanism of action and response of clinically relevant markers.Methods: We conducted a longitudinal cohort study in 2012-2013 in G551D CF patients age 6 and older with no prior exposure to ivacaftor. Study assessments were performed at baseline, 1, 3, and 6 months after ivacaftor initiation. Substudies evaluated mucociliary clearance, b-adrenergic sweat secretion rate, gastrointestinal pH, and sputum inflammation and microbiology Measurements and Main Results: A total of 151 of 153 subjects were prescribed ivacaftor and 88% completed the study through 6 months. FEV 1 % predicted improved from baseline to 6 months (mean absolute change, 6.7%; P , 0.001). Similarly, body mass index improved from baseline to 6 months (mean change, 0.8 kg/m 2 ; P , 0.001). Sweat chloride decreased from baseline to 6 months (mean change, 253.8 mmol/L; 95% confidence interval, 257.7 to 249.9; P , 0.001), reflecting augmented CFTR function. There was significant improvement in hospitalization rate (P , 0.001) and Pseudomonas aeruginosa burden (P , 0.01). Significant improvements in mucociliary clearance (P , 0.001), gastrointestinal pH (P = 0.001), and microbiome were also observed, providing clinical mechanisms underlying the therapeutic benefit of ivacaftor.Conclusions: Significant clinical and physiologic improvements were observed on initiation of ivacaftor in a broad patient population, including reduced infection with P. aeruginosa. Biomarker studies substantially improve the understanding of the mechanistic consequences of CFTR modulation on pulmonary and gastrointestinal physiology.

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Intractable cough in a preterm infant with ventriculoperitoneal shunt

Cited by 2 publications

References 15 publications

Tic Cough in an Adolescent with Organic Brain Pathology—A Case Report and Literature Review

Tic Cough in an Adolescent with Organic Brain Pathology—A Case Report and Literature Review

Clinical Mechanism of the Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor in G551D-mediated Cystic Fibrosis

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