Intractable hiccup induced by cavernous angioma in the medulla oblongata: case report

Intractable Hiccup as the Presenting Symptom of Cavernous Hemangioma in the Medulla Oblongata: A Case Report and Literature Review

“…However, these case series did not reveal the detail description on the exact location, and clinico-radiological characteristics. For this reason, medullary caverrnoma presenting as intractable hiccup has been reported as a single case report, with the explanation of unique clinical course (Table 1)4,11,12,15,18). Majority of reported cases were in male patients (female in only one case) with the mean age of 34.8 years, relatively younger than the patients with general brainstem CHs in a large series (41.8 years in brainstem CHs; 44.1 years in medullary CH)1).…”

“…It can be considered persistent or intractable when it lasts more than 24 hours11). The exact etiology of hiccup remains unclear in most cases.…”

“…Although few reports demonstrated surgically treated and pathologically confirmed cavernous hemangioma (CH) in the medulla oblongata4,11,12,15,18), most of them were superficially located in the dorsal part of the medulla oblongata. In the current case, the authors demonstrate the fully embedded medullary cavernoma with intractable hiccup surgically treated without morbidity and discuss possible pathogenesis of this condition with a review of the reported cases and related literature.…”

Intractable Hiccups Post Stroke: Case Report and Review of the Literature

“…IH are also seen in a variety of space occupying lesions including cavernous angiomas [10][11][12], haemangioblastomas [13], astrocytomas [14] and tuberculomas [15]. It is of note that IH can be the initial and often only presenting complaint in many of these patients.…”

Supratentorial infarcts accompanying hiccup

“…The main causes of hiccup can be classified as: central nervous system; psychiatric; metabolic; toxic and infectious; ear, nose, and throat disease; thoracic; and abdominal (Kahrilas & Shi, 1997;Launois et al, 1993;Marsot-Dupuch et al, 1995). Although the main culprit lesion in the central nervous system causing hiccup is thought to involve the brainstem, including the medulla oblongata or pons (al Deeb, Sharif, al Moutaery, & Biary, 1991;Kim, 2003;Kobayashi et al, 2009;Kumar & Dromerick, 1998;Liu, Fuh, & Wang, 2008;Mattana, Mattana, & Roxo, 2010;Musumeci, Cristofori, & Bricolo, 2000;Park et al, 2005), a few cases with persistent or intractable hiccups caused by damage to the supratentorial cortex have been reported (van Durme, Idema, & van Guldener, 2008;Jansen, Joosten, & Vingerhoets, 1990;Lee, Pritchard, & Weiner, 2011;Longatti, Basaldella, Moro, Ciccarino, & Franzini, 2010;Marsot-Dupuch et al, 1995;Tiedt & Wenzel, 2013). However, the characteristics of patients showing hiccups due to supratentorial lesions have not yet been fully elucidated.…”