Intracystic (encysted) papillary carcinoma of the breast: A clinical, pathological, and immunohistochemical study

Leal, Concei ça ̃o; Costa, Isabel; Fonseca, Daniel; Lopes, Paula; Bento, Maria-José; Lopes, Carlos

doi:10.1016/s0046-8177(98)90420-8

Cited by 88 publications

(83 citation statements)

References 12 publications

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“…Usually intra cystic papillary breast cancers reveal low or intermediate nuclear grade without necrosis. They show strong immunopositivity for estrogen and progesterone receptor and negativity for Her2 net [7]. IPC associated with invasive carcinoma are of high nuclear grade and necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically EPC is characterized by papillary configuration within a well-circumscribed cystic or distended duct with cytological features similar to papillary DCIS. These lesions lack myoepithelial cells at their periphery, in contact to DCIS which exhibits myoepithelial cell at the periphery; recently many authors have considered EPCs as, invasive carcinomas with an expansile growth [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Those have been studied by Immunohistochemical targeting these proteins which demonstrated linear and continuous basement membranes in benign and in situ lesions and discontinuous or absent expression in invasive carcinoma [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An Unusual Case of High Grade Triple Negative Intracystic Solid Papillary Carcinoma of Breast with Invasive Component

Junainah¹,

Baslaim²,

Shigairi³

et al. 2017

J Clin Exp Pathol

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Background: Intracystic (encysted) papillary carcinoma (IPC) is a rare distinct entity of breast cancer, usually asymptomatic, sometimes presented as breast mass or nipple discharge. It shows benign appearance on imaging. Ultrasonography shows pure cyst or mixed image, sometime solid mass. Pathologically can be divided into pure form, or associated with ductal carcinoma in situ (DCIS) or invasive carcinoma. It is considered as noninvasive or minimally invasive, because there is no infiltrating growth pattern and metastases are rare. Traditionally considered to lack a myoepithelial layer, it has favorable prognosis even with invasion. Stromal invasion found in 92%. In case of high grade variant which diagnosed by high nuclear grade and high mitotic activity, usually triple negative and p53+ as we have in our case?

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Unusual Case of High Grade Triple Negative Intracystic Solid Papillary Carcinoma of Breast with Invasive Component

Junainah¹,

Baslaim²,

Shigairi³

et al. 2017

J Clin Exp Pathol

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“…Pathologically, IPC appears as a grossly visible mass with a cystic component that may have a papillary, nodular or shaggy inner surface. It often has fibrous and vascular elements, and necrosis is often a prominent feature when an associated invasive component is present (4,6). Hemorrhagic areas are often identified within the solid components of the tumor; these areas contain blood and fluid within the cystic spaces (7).…”

Section: Discussionmentioning

confidence: 99%

Intracystic Papillary Carcinoma with Extensive Hemorrhage of the Breast: Sonographic and Advanced MR Findings: A Case Report

Woo

Yong

Kim

et al. 2006

J Korean Radiol Soc

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Intracystic papillary carcinoma (IPC) of the breast is a rare tumor, and it has a much better prognosis than other types of breast carcinoma (1). Making the preoperative diagnosis of IPC via the clinical examination, ultrasonography and MR imaging is important to plan proper surgical treatment. Several studies have shown that MR imaging of IPC of the breast in a diagnostic setting is sensitive for identifying this malady (2, 3). We experienced a case of IPC that was diagnosed in an 83-yearold-woman. We describe here the clinical findings, ultrasonography and MR imaging that proved to be successful in making an accurate preoperative diagnosis. Case ReportAn 83-year-old woman had a 5-year history of a mass located in her right breast. She had not received any treatment for the mass because it was asymptomatic. She became aware of enlargement of the mass accompanied with pain and redness of the overlaying skin for the last one month, and she came to our department with spontaneous bleeding due to tearing of the overlaying skin. The physical examination revealed a palpable 8.0 9.0 cm well-circumscribed, firm, mobile, huge mass. Palpation did not reveal any abnormality in the axillary lymph nodes. There was no history of breast trauma.Ultrasonography (US) was performed using a 5 12 MHz linear array transducer and a 5 8 MHz convex transducer (HDI 5000; ATL, Bothell, WA). US of the right breast mass showed a very large complex mass with an anechoic cystic portion, mural nodularity and papillary projections (Fig. 1A). Doppler US demonstrated a flow within the lateral wall portion of the mass and mural nodules (not shown Intracystic papillary carcinoma (IPC) of the breast is very rare, and it has a much better prognosis than the other types of breast carcinoma. We experienced a case of intracystic papillary carcinoma that we diagnosed in an 83-year-old-woman. MR imaging of the IPC shows a multicystic appearance with a subacute or chronic stage of intracystic hemorrhage. The contrast-enhanced MR imaging demonstrates enhancement of the cyst wall and mural nodules, and this modality proved to be successful for making an accurate preoperative diagnosis.

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“…Traditionally, IPC was considered to be a variant of DCIS, as a localized form of intraductal papillary carcinoma that exists in a cystically dilated duct. (2) Although it has been believed that IPC may exist as an isolated localized non-invasive carcinoma, being associated with DCIS or with invasive carcinoma,(3) recent studies have suggested that IPC should be considered as a low risk invasive carcinoma. (4) We tried to find out the data of IPC of Korean women, but only five reports of a single case could be found through the web-based search of KoreaMed (http://www.…”

Section: Introductionmentioning

confidence: 99%

Experience with Intracystic Papillary Carcinoma of the Breast at a Single Institute in Korea

et al. 2009

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Intracystic (encysted) papillary carcinoma of the breast: A clinical, pathological, and immunohistochemical study

Cited by 88 publications

References 12 publications

An Unusual Case of High Grade Triple Negative Intracystic Solid Papillary Carcinoma of Breast with Invasive Component

An Unusual Case of High Grade Triple Negative Intracystic Solid Papillary Carcinoma of Breast with Invasive Component

Intracystic Papillary Carcinoma with Extensive Hemorrhage of the Breast: Sonographic and Advanced MR Findings: A Case Report

Experience with Intracystic Papillary Carcinoma of the Breast at a Single Institute in Korea

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