Intracystic Papillary Carcinoma of the Breast: Report of Three Cases and Literature Review

Abstract

Intracystic papillary carcinoma is a rare malignant tumor of the breast. It occurs communally in postmenopausal women. Clinically it can be asymptomatic or manifested by a breast mass or a nipple discharge. On imaging intracystic papillary carcinoma has usually benign features. Pathologic diagnosis can be difficult at classical histological examination and identification of myoepithelial cells layer by immunohistochemical study can be useful. In the majority of cases of pure intracystic papillary carcinoma, conservative management is possible. Adjuvant therapy is still controversial and prognosis is excellent. We report three cases of intracystic papillary carcinoma diagnosed on immunohistochemical examination and managed with conservative surgery.

Epidemiological features of papillary carcinoma of the breast in a developing community

“…This is unlike the many reports on encapsulated papillary carcinoma [6][7][8][9] and even the intracystic variety [10,11]. Of course, explanations were attempted in all of them (Table 2) (Figure 2).…”

An Unusual Case of High Grade Triple Negative Intracystic Solid Papillary Carcinoma of Breast with Invasive Component

“…Ultrasound guided core biopsy of suspected intra cystic mass has been suggested by many authors to differentiate benign from malignant papillary neoplasms but failed to distinguish in situ from invasive papillary carcinoma as invasion is found in peripheral part of the tumor [9]. Tomonori et al [10] also suggested necessity of excisional biopsy.…”

“…Those have been studied by Immunohistochemical targeting these proteins which demonstrated linear and continuous basement membranes in benign and in situ lesions and discontinuous or absent expression in invasive carcinoma [1][2][3][4][5][6][7][8][9].…”

Intracystic Carcinoma of the Breast: Report of Two Cases

“…In some cases, nipple discharge may be the first sign (4). On ultrasonography (US) it may appear cystic, semi solid or solid (5). Microcalcifications may accompany the lesion on mammograms (4).…”

“…Although treatment methods are still controversial, surgery remains the treatment of choice (3). Endocrine therapy and radiation therapy are used in most medical centers but the evidence indicating that this method improves prognosis is still insufficient (5). Two patients with IPC who were treated at our clinic are presented together with the relevant literature.…”