Intraday Repeatability of Bruch's Membrane Opening-Based Neuroretinal Rim Measurements

Enders, Philip; A, Bremen; Schaub, Friederike; Hermann, Manuel M.; Diestelhorst, Michael; Dietlein, Thomas S.; Cursiefen, Claus; Heindl, Ludwig M.

doi:10.1167/iovs.17-22812

Cited by 26 publications

(18 citation statements)

References 27 publications

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“…Various authors have indicated the utility of BMO-MRW in diagnosing glaucoma in moderate myopic eyes [8] or small optic discs [9]. BMO-MRW also showed high intraday repeatability, similar to the RNFL thickness parameters, and independence from intraindividual intraocular pressure (IOP) changes [10].…”

Section: Introductionmentioning

confidence: 97%

Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol

et al. 2020

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Background: Bruch membrane opening-minimum rim width (BMO-MRW) assessment offers a new diagnostic use in glaucoma patients of the Glaucoma Module Premium Edition (GMPE) available for the Spectralis optical coherence tomography (OCT) system. The objective of our research was to evaluate the diagnostic benefits of examining BMO-MRW and peripapillary retinal nerve fibre layer (pRNFL) readings acquired with Spectralis OCT to distinguish between healthy and mild glaucoma patients, comparing those readings with the standard pRNFL application. Moreover, we investigated whether using a particular combination of BMO-MRW and pRNFL parameters with a linear discriminant function (LDF) could further enhance glaucoma diagnosis. Methods: One hundred thirty-six eyes from 136 individuals were incorporated into this observational, prospective cross-sectional study: 68 mild primary open-angle glaucoma (POAG) patients according to the Hodapp-Parrish-Anderson criteria (mean deviation between 0 and − 6 dB) and 68 healthy control subjects selected by Propensity Score Matching. MRW and pRNFL thickness around the disc (diameters: 3.5 mm, 4.1 mm, and 4.7 mm) were obtained using the BMO-MRW protocol, and pRNFL thickness at 3.5 mm was obtained with the standard glaucoma application. The group data were contrasted. One sample was chosen at random to develop the LDF (teaching set: 34 healthy subjects and 34 POAG patients) using a combination of MRW and pRNFL parameters (acquired with the BMO-MRW protocol); the other sample provided a test of how the LDF performed on an independent group (validating set: 34 healthy subjects and 34 POAG patients). The receiver operating curves (ROCs) were plotted for every measurement and contrasted with the proposed LDF. The OCT parameters with the best area under the receiver operating characteristic curve (AUC) were determined. Results: Global MRW and pRNFL thicknesses were significantly thinner in the POAG group (p < 0.001). The BMO-MRW parameters showed good diagnostic accuracy; the largest AUCs reached 0.875 for the LDF and 0.879 for global RNFL thickness using the standard glaucoma application. There were no statistical differences between the AUCs calculated. Conclusions: BMO-MRW parameters show a strong capability to differentiate between mild glaucoma and control eyes. Our LDF based on the new BMO-MRW OCT protocol did not perform better than isolated parameters.

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Section: Introductionmentioning

confidence: 97%

Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol

et al. 2020

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“…Simply because the actual value of BMO-MRW is greater than that of RNFL, it does not necessarily indicate that values of BMO-MRW are more variable than values of RNFL. Previous studies have revealed that BMO-MRW offers excellent intra-and interobserver reproducibility and intraday repeatability [30][31][32]. The thicker the measurement tissue is, the more there is left to measure over time.…”

Section: Discussionmentioning

confidence: 99%

Rate of Change in Bruch’s Membrane Opening-Minimum Rim Width and Peripapillary RNFL in Early Normal Tension Glaucoma

Cho

Kee

2020

JCM

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Background: to investigate the rate of change (ROC) of Bruch’s membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness in early normal tension glaucoma (NTG) patients. Methods: in this longitudinal cohort study, 115 subjects (115 eyes) diagnosed as early NTG (mean deviation > −6.0 dB) and who had completed more than five times of spectral-domain optical coherence tomography (OCT) tests with acceptable quality were included. Measurement of BMO-MRW and RNFL were performed at 3-month intervals by OCT. Linear mixed-effects model was employed to calculate the ROC in global region and six Garway-Heath sectors with adjusting age, sex, and BMO area. Results: Average follow-up was 20.99 ± 6.99 months with OCT number of 7.54 ± 2.12. Baseline intraocular pressure was 14.72 ± 2.70 mmHg and MD was −2.73 ± 2.26 dB. ROC of global BMO-MRW was −2.06 ± 0.65 µm/yr and RNFL was −0.96 ± 0.16 µm/yr (p = 0.098). The most rapid ROC was in inferotemporal sector (BMO-MRW: −3.02 ± 0.88 µm/yr, RNFL: −1.96 ± 0.36 µm/yr) followed by superotemporal sector. Conclusion: The ROC of BMO-MRW, the new parameter along with that of RNFL should be considered in the management of early NTG. BMO-MRW may show visible reduction ROC better than RNFL to detect early progression in early NTG when visual field may not show significant change.

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“…For subjects with either glaucoma or ocular hypertension, mean baseline BMO‐MRW and SD were estimated to 206 and 86 μ m, respectively (Enders et al. ).…”

Section: Introductionmentioning

confidence: 99%

“…Commercially available automated algorithms are still under development. Manual review and correction is still required (Enders et al 2017;Park et al 2017;Reis et al 2017;Schrems-Hoesl et al 2018;Tun et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Melin

Söderberg

2019

Acta Ophthalmologica

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Purpose To estimate the sources of variation for Pigment epithelium central limit‐Inner limit of the retina Minimal Distance averaged over 2π (PIMD‐2π), and further to analyse their consequences for clinical measurements of glaucoma. Methods Forty subjects with early to moderate stage glaucoma were included. Three SD‐OCT volumes of the optic nerve head (ONH) were captured at two occasions. Each volume was segmented three times for PIMD‐2π. The magnitude of the sources of variation for PIMD‐2π measurements was estimated with an analysis of variance. Results A 95% confidence interval for mean PIMD‐2π was estimated to 215 ± 12 μm (df = 38). The estimated variance for subjects was 1280 μm2. The within‐subject estimated variance for occasions, volumes and segmentations was 10 μm2, 30 μm2 and 40 μm2, respectively. The within‐subject variances were used to model follow‐up of PIMD‐2π over time. A linear loss rate of 0.05 of baseline PIMD‐2π/year was assumed. A significant PIMD‐2π change could be detected in approximately 16–18 months with evenly spaced visits every 4 or 6 months. Conclusions Due to the small within‐subject estimated variances, a clinically undesirable PIMD‐2π change from baseline can be detected in approximately 18 months. Detection of significant PIMD‐2π loss in a subject requires knowledge of normal age loss and measurement variability.

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Intraday Repeatability of Bruch's Membrane Opening-Based Neuroretinal Rim Measurements

Cited by 26 publications

References 27 publications

Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol

Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol

Rate of Change in Bruch’s Membrane Opening-Minimum Rim Width and Peripapillary RNFL in Early Normal Tension Glaucoma

Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

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