Intradermal mesotherapy versus systemic therapy in the treatment of musculoskeletal pain: A prospective randomized study

Koçak, Abdullah Osman

doi:10.1016/j.ajem.2019.02.042

Cited by 19 publications

(28 citation statements)

References 21 publications

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“… 7 Many studies have investigated the efficacy of mesotherapy on pain relief in health conditions other than migraine. 12 , 14 , 30 , 31 Those studies reported that mesotherapy can be a good treatment option for pain relief when compared to different analgesics. Nevertheless, there is no published study that has compared mesotherapy with systemic use of analgesics for the efficiency or safety of the treatment of migraine headache.…”

Section: Discussionmentioning

confidence: 99%

“…The agents and doses in the drug cocktail were found efficient and safe for painkilling in our previous studies. 12 , 14 In the systemic therapy group, an intravenous infusion included 50 mg dexketoprofen (Revafen, Haver Pharma Pharmaceutical Co., Turkey) in 100 cc normal saline that was infused over 5 minutes.…”

Section: Methodsmentioning

confidence: 99%

“…Mesotherapy may be an efficient treatment method in the treatment of fibromyalgia, gout, headache, neuralgia, low back pain, sports injury, and musculoskeletal pain. 11 – 14 Mesotherapy has a dual mechanism in pain relief, one of which is the process of introducing needles into the skin that stimulates a reflex action by increasing endorphin levels, and the second is the local effect of the drug. 15 Besides, to the best of our knowledge, there is no published study that has compared mesotherapy with any systemic treatment method.…”

Section: Introductionmentioning

confidence: 99%

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Intradermal mesotherapy versus intravenous dexketoprofen for the treatment of migraine headache without aura: a randomized controlled trial

Akbaş

Koçak²,

Koçak

et al. 2021

Ann Saudi Med

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BACKGROUND: Migraine is a prevalent disabling primary headache disorder that is classified into two major types: migraine without aura and migraine with aura. New therapeutic methods to reduce migraine headaches in the emergency department (ED) include intradermal mesotherapy. OBJECTIVE: Compare the efficacy of intradermal mesotherapy versus a systemic therapy in pain control in patients with headache related to migraine without aura. DESIGN: Prospective parallel-group randomized controlled trial. SETTING: University hospital in Turkey. PATIENTS AND METHODS: Patients 18 years of age and older who were admitted to the ED over a 15-month period with headache related to migraine without aura were eligible for inclusion if they had a VAS score of 4 or above. Patients were randomly allocated to one session of mesotherapy or intravenous dexketoprofen. Changes in pain intensity were measured by the score on a visual analog scale (VAS) at 30, 60, and 120 minutes and 24 hours after treatment. Efficacy was also assessed by the need for use of an analgesic drug within 24 hours, by readmission with the same complaint to the ED within 72 hours, and by adverse effect rates. MAIN OUTCOME MEASURE: Pain intensity on the VAS scale. SAMPLE SIZE: 148 patients (154 enrolled and treated; 1 patient in the mesotherapy and 5 patients in the systemic therapy group lost to follow up). RESULTS: Pain intensity on the VAS scale decreased from a median score of 8 to 4 in the mesotherapy group and from 8 to 5 in the systemic therapy group. These differences were statistically significant from baseline for all time intervals ( P =.001 to 30 minutes, P =.004 to 60 minutes, P =.005 to 120 minutes, and P =.002 to 24 hours). The need to use analgesics and the rate of readmission to the ED were higher in the systemic therapy group ( P =.013 and P =.030, respectively). Adverse effect rates were minimal and similar in the study groups during the one-week follow-up period. CONCLUSIONS: Mesotherapy is more efficacious than intravenous dexketoprofen in the management of acute attack of migraine without aura in the ED. LIMITATIONS: Unblinded. Valid for assessing short-term pain relief, but not sufficient to predict long-term efficacy. Not generalizable because single center and small sample size. CONFLICT OF INTEREST: None. REGISTRATION: ClinicalTrials.gov (NCT04519346)

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intradermal mesotherapy versus intravenous dexketoprofen for the treatment of migraine headache without aura: a randomized controlled trial

Akbaş

Koçak²,

Koçak

et al. 2021

Ann Saudi Med

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“…In favor of this hypothesis, data have recently been recorded in favor of intradermal treatment both with respect to the oral route [17] and to the intravenous route [18]. It would be interesting to compare lidocaine patch versus lidocaine mesotherapy in a randomized controlled trial.…”

Section: Discussionmentioning

confidence: 99%

Post-Herpetic Pain Managed According to The Recommendations of the Italian Society of Mesotherapy

Russo¹,

Mammucari

Natoli

et al. 2021

Asp Biomed Clin Case Rep

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Drugs injected intradermally spread slowly into the underlying tissues and produce a drug-saving effect. The Italian society of mesotherapy suggested that intradermal therapy obtains analgesic effect on localized pain, with a lower risk of systemic drug interactions. We report a case of post-herpetic pain successfully treated by this technique. This case confirms that the intradermal administration technique (mesotherapy), which is based on the pathophysiology of the disorder, according to the recommendations, can contribute to the management of patients who do not tolerate standard therapies.

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“…Chen [16] and Saggini [12] found significant improvement in the physical function, lower consumption of analgesics, and less adverse events compared to oral treatment. Kocak [17] conducted a randomized trial to evaluate the effects of LIT treatment compared to intravenous administration of anti-inflammatories. He found that patients treated in an emergency room for musculoskeletal e Scientific World Journal pain reported significant better pain control after a single mesotherapy treatment.…”

Section: Analgesic Mechanism Of Actionmentioning

confidence: 99%

Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects

Mammucari

Maggiori

Russo³

et al. 2020

The Scientific World Journal

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Intradermal therapy, known as mesotherapy, is a technique used to inject a drug into the surface layer of the skin. In particular, it involves the use of a short needle to deposit the drug in the dermis. The intradermal microdeposit modulates the drug’s kinetics, slowing absorption and prolonging the local mechanism of action. It is successfully applied in the treatment of some forms of localized pain syndromes and other local clinical conditions. It could be suggested when a systemic drug-sparing effect is useful, when other therapies have failed (or cannot be used), and when it can synergize with other pharmacological or nonpharmacological therapies. Despite the lack of randomized clinical trials in some fields of application, a general consensus is also reached in nonpharmacological mechanism of action, the technique execution modalities, the scientific rationale to apply it in some indications, and the usefulness of the informed consent. The Italian Mesotherapy Society proposes this position paper to apply intradermal therapy based on scientific evidence and no longer on personal bias.

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Intradermal mesotherapy versus systemic therapy in the treatment of musculoskeletal pain: A prospective randomized study

Cited by 19 publications

References 21 publications

Intradermal mesotherapy versus intravenous dexketoprofen for the treatment of migraine headache without aura: a randomized controlled trial

Intradermal mesotherapy versus intravenous dexketoprofen for the treatment of migraine headache without aura: a randomized controlled trial

Post-Herpetic Pain Managed According to The Recommendations of the Italian Society of Mesotherapy

Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects

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