Intradermal post-exposure rabies vaccination with purified Vero cell rabies vaccine: Comparison of a one-week, 4-site regimen versus updated Thai Red Cross regimen in a randomized non-inferiority trial in the Philippines

Quiambao, Beatriz P.; Ambas, Cristina; Diego, Sherylle; Castells, Valérie Bosch; Korejwo, Joanna; Petit, Céline; Houillon, G

doi:10.1016/j.vaccine.2019.02.083

Cited by 13 publications

(13 citation statements)

References 19 publications

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“…The RAC17 study reported GMTs for two PVRV ID regimens (0,3,7,14,28,90 [2-2-2-0-1-1] and 0,3,7,14,28,90 [2-2-2-0-2-0]) of 80.8 and 72.9 IU/mL at day 14, respectively, and 43.8 and 45.4 IU/mL at day 28 [52], which are outlying data compared to other studies and were therefore not included in the ranges reported overall. Seroconversion rates were maintained at 50-100% at 1 year, with GMTs decreasing to 0.42-1.37 IU/mL [37,42,46,48,50]. These results were, in general, slightly lower than those reported without RIG use in simulated PEP in otherwise healthy participants.…”

Section: Immunogenicity Up To 1 Yearmentioning

confidence: 63%

“…There were 26 citations identified that reported immunogenicity data following ID PVRV as part of PEP [25,26,28,; of these 14 studies were undertaken in Thailand [25,28,30,[32][33][34]37,39,42,44,[46][47][48]51], and 5 in India [35,36,38,43,45]. Three studies were undertaken in The Philippines [40,50,52], and one included long-term follow up to year 5 [31,50]. The remainder were undertaken in Lithuania, the UK, and Cambodia [41,49,53].…”

Section: Immunogenicity Of Pep Regimensmentioning

confidence: 99%

“…No studies were undertaken specifically in children alone; 13 studies included children and adults [25,33,34,[38][39][40][45][46][47][50][51][52][53] or did not specify the age group [42], and the rest were in adults only. These studies were mainly undertaken in patients/participants without prior rabies vaccine experience (prior rabies vaccine experience was usually an exclusion criterion in these studies, except in three studies [28,32,33]).…”

Section: Immunogenicity Of Pep Regimensmentioning

confidence: 99%

“…The studies that assessed regimens that included RIG reported 99-100% seroconversion rates from day 14 to 28 after the first vaccination (except for one study that reported 100% seroconversion at day 14 that decreased to 90% at day 28 [37]), with GMTs ranging from 2.7 to 19.7 IU/mL [42,45,46,48,50]. Figure 4 summarizes the RVNA GMTs reported across the studies that included concomitant RIG.…”

Section: Immunogenicity Up To 1 Yearmentioning

confidence: 99%

“…These results were, in general, slightly lower than those reported without RIG use in simulated PEP in otherwise healthy participants. Eleven studies assessed PEP that included rabies immune globulin (equine rabies immune globulin [ERIG] or human rabies immune globulin [HRIG]) [35,37,40,42,[45][46][47][48]50,52,53], excluding one study in HIV patients reported in greater detail below [51]. The ID PVRV PEP vaccination regimens concomitant with RIG are also summarized in Table 1 along with the type of patient/participants assessed.…”

Section: Immunogenicity Up To 1 Yearmentioning

confidence: 99%

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Purified Vero Cell Rabies Vaccine (PVRV, Verorab®): A Systematic Review of Intradermal Use Between 1985 and 2019

et al. 2020

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The purified Vero cell rabies vaccine (PVRV; Verorab ® , Sanofi Pasteur) has been used in rabies prevention since 1985. Evolving rabies vaccination trends, including shorter intradermal (ID) regimens with reduced volume, along with WHO recommendation for ID administration has driven recent ID PVRV regimen assessments. Thus, a consolidated review comparing immunogenicity of PVRV ID regimens during pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) is timely and beneficial in identifying gaps in current research. A search of seven databases for studies published from 1985 to November 2019 identified 35 studies. PrEP was assessed in 10 studies (n = 926) with 1-3-site, 1-3-visit regimens of up to 3-months duration. Seroconversion (rabies virus neutralizing antibodies [RVNA] ≥ 0.5 IU/mL) rates of 90-100% were reported within weeks, irrespective of regimen, with robust booster responses at 1 year (100% seroconversion rates by day 14 post-booster). However, data are lacking for the current WHO-recommended, 2-site, 1-week ID PrEP regimen. PEP was assessed in 25 studies (n = 2136) across regimens of 1-week to 90-day duration. All ID PEP regimens assessed induced ≥ 99% seroconversion rates (except in HIV participants) by day 14-28. This review confirms ID PVRV suitability for rabies prophylaxis and highlights the heterogeneity of use in the field.

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Section: Immunogenicity Up To 1 Yearmentioning

confidence: 63%

Section: Immunogenicity Of Pep Regimensmentioning

confidence: 99%

Section: Immunogenicity Of Pep Regimensmentioning

confidence: 99%

Section: Immunogenicity Up To 1 Yearmentioning

confidence: 99%

Section: Immunogenicity Up To 1 Yearmentioning

confidence: 99%

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Purified Vero Cell Rabies Vaccine (PVRV, Verorab®): A Systematic Review of Intradermal Use Between 1985 and 2019

et al. 2020

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Immune-adjuvant effect of vitamin A and probiotics supplementation on humoral response to cell culture rabies vaccine in rabbits

et al. 2023

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This study was carried out to evaluate the effects of vitamin A (Vit A) and probiotic co-supplementation with rabies vaccine on humoral immune response in New Zealand white (NZW) rabbits. For this experiment, 54 rabbits were randomized into six experimental and three control groups. Mixed cultures of commercial probiotics supplements and a dose of Vit A were administered to each animal. Results were compared with the control group fed with only basal diet. Animals in different treatment groups showed significantly higher sero-conversions against rabies vaccine. There was a significant increase (p < 0.001) in the titers of rabies antibodies in all treatment groups on 14th and 35th days than control C3 group. Both commercial probiotics irrespective of brand increase the humoral immune response of rabbits against rabies vaccine. The mean titer values of all groups G1-G6 and sub-controls (C1, C2) were generally above 3.6 EU/ml on day 14th and between 3.7 and 3.9 EU/ml, showing highest sero-conversion on 35th day than mean titer of C3 control = 3.091 and 3.505 EU/ml respectively on both days. The maximum titer values were obtained with the addition of organic carrots to the daily diet. These results suggest that simple dietary interventions using probiotics and Vit A in natural form may enhance the efficacy of rabies vaccine in the host. These cost-effective strategies can be applied for getting higher yields of polyclonal antibody production in animal models, thus providing promising means of improving the final product yield and can be adopted easily by the manufacturers.

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Towards rabies elimination in the Asia-Pacific region: From theory to practice

Rupprecht¹,

Abela-Ridder

Abila

et al. 2020

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Intradermal post-exposure rabies vaccination with purified Vero cell rabies vaccine: Comparison of a one-week, 4-site regimen versus updated Thai Red Cross regimen in a randomized non-inferiority trial in the Philippines

Cited by 13 publications

References 19 publications

Purified Vero Cell Rabies Vaccine (PVRV, Verorab®): A Systematic Review of Intradermal Use Between 1985 and 2019

Purified Vero Cell Rabies Vaccine (PVRV, Verorab®): A Systematic Review of Intradermal Use Between 1985 and 2019

Immune-adjuvant effect of vitamin A and probiotics supplementation on humoral response to cell culture rabies vaccine in rabbits

Towards rabies elimination in the Asia-Pacific region: From theory to practice

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