Intradermal skin tests for rocuronium and cisatracurium in patients with a history of allergy: a retrospective study

Abstract

BackgroundNeuromuscular blocking agents (NMBAs) are a leading cause of perioperative anaphylaxis. However, the performance of systematic screening skin tests to detect reactions for NMBAs prior to general anesthesia is not recommended. We retrospectively examined intradermal tests (IDTs) for rocuronium and cisatracurium in patients with a history of allergy.MethodsWe reviewed the records of patients who underwent IDTs for NMBAs between January 1 and December 31, 2016. We analyzed the patients’ allergy histories and skin test results for NMBAs.ResultsThe overall prevalence of positive IDTs was 5.8% (26/451), and there was no significant difference in prevalence among allergy types (P = 0.655). In logistic regression analysis, there was no allergy history that had a significant effect on positive IDT for NMBAs.ConclusionsWe found no association between allergy history and positive skin test for NMBAs. Therefore, a systematic screening test for NMBAs or other anesthetic agents before anesthesia is not considered necessary even in patients with an allergy history.

Negative association between previous allergy and intradermal tests for rocuronium and cisatracurium: what about additional tests?

“…In a retrospective analysis published in the Korean Journal of Anesthesiology [ 1 ] concerning the relationship between intradermal tests for neuromuscular blocking agents in patients with history of allergy to various anesthetic agents, no association between allergy history and positive skin test was found.…”