Intradermal skin tests in the diagnostic evaluation of food allergy

Sampson, Hugh A.; Rosen, James P.; Selcow, Jay E.; Mendelson, Louis M.; Grodofsky, Marshall P.; Factor, Jeffrey M.; Bock, S. Allan; Burks, A. Wesley; James, John M.; Zeiger, Robert S.; Yunginger, John W.

doi:10.1016/s0091-6749(96)70111-2

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…There are no published reports of the correlation between RAST and ELISA for detection of nut-specific IgE, but our results suggest that ELISA testing is more sensitive than RAST. RAST testing for peanut-specific IgE has previously demonstrated a false-negative rate of approximately 15% [21]. Within our study, several subjects demonstrated a positive RAST score and ELISA in the absence of a clinical history.…”

Section: Discussionsupporting

confidence: 54%

Immunological analysis of allergenic cross‐reactivity between peanut and tree nuts

Leon

Glaspole

Drew

et al. 2003

Clin Experimental Allergy

124

100

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Section: Discussionsupporting

confidence: 54%

Immunological analysis of allergenic cross‐reactivity between peanut and tree nuts

Leon

Glaspole

Drew

et al. 2003

Clin Experimental Allergy

124

100

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“…If we are able to do so, then the potential exists for using intradermal tests to foods because these patients would meet the proposed criteria. 28 Finally, most patients reported the onset of symptoms within the last 2 to 3 years, challenging the notion that the incidence of adult-onset mammalian meat allergy is rare.…”

Section: Discussionmentioning

confidence: 99%

Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose

Commins

Satinover

Hosen

et al. 2009

Journal of Allergy and Clinical Immunology

620

641

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Background Carbohydrate moieties are frequently encountered in food and can elicit IgE responses, the clinical significance of which has been unclear. Recent work, however, has shown that IgE antibodies to galactose-α-1,3-galactose (α-gal), a carbohydrate commonly expressed on nonprimate mammalian proteins, are capable of eliciting serious, even fatal, reactions. Objective We sought to determine whether IgE antibodies to α-gal are present in sera from patients who report anaphylaxis or urticaria after eating beef, pork, or lamb. Methods Detailed histories were taken from patients presenting to the University of Virginia Allergy Clinic. Skin prick tests (SPTs), intradermal skin tests, and serum IgE antibody analysis were performed for common indoor, outdoor, and food allergens. Results Twenty-four patients with IgE antibodies to α-gal were identified. These patients described a similar history of anaphylaxis or urticaria 3 to 6 hours after the ingestion of meat and reported fewer or no episodes when following an avoidance diet. SPTs to mammalian meat produced wheals of usually less than 4 mm, whereas intradermal or fresh-food SPTs provided larger and more consistent wheal responses. CAP-RAST testing revealed specific IgE antibodies to beef, pork, lamb, cow’s milk, cat, and dog but not turkey, chicken, or fish. Absorption experiments indicated that this pattern of sensitivity was explained by an IgE antibody specific for α-gal. Conclusion We report a novel and severe food allergy related to IgE antibodies to the carbohydrate epitope α-gal. These patients experience delayed symptoms of anaphylaxis, angioedema, or urticaria associated with eating beef, pork, or lamb.

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“…32 It is important to understand that many children suffer from milk allergy, but IgE to a-Gal is distinct from the more traditional, protein-based cow' s milk allergy. a-Gal-related reactions present in older children, many of whom have no previous history of either food allergy or any allergic disease.…”

Section: Figurementioning

confidence: 99%

Galactose-α-1,3-galactose and Delayed Anaphylaxis, Angioedema, and Urticaria in Children

Kennedy¹,

Stallings²,

Platts-Mills³

et al. 2013

Pediatrics

115

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Intradermal skin tests in the diagnostic evaluation of food allergy

Cited by 6 publications

References 3 publications

Immunological analysis of allergenic cross‐reactivity between peanut and tree nuts

Immunological analysis of allergenic cross‐reactivity between peanut and tree nuts

Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose

Galactose-α-1,3-galactose and Delayed Anaphylaxis, Angioedema, and Urticaria in Children

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