Intradermal Therapy (Mesotherapy) with Lymdiaral in Chronic Venous Insufficiency and Associated Fibrosclerotic Edema Damage: A Pilot Study

Abstract

Its open-label design and small sample size notwithstanding, this study indicates that intradermal therapy, according to the recommendation of the Italian Society of Mesotherapy, may provide a valuable contribution to the treatment of CVI and related fibrosclerotic edema of the subcutaneous tissue by prolonging the local effect of the pharmacologically active compounds. Comparative studies are needed to identify the broader clinical and economic benefits of local therapy compared with other systemic therapies.

Efficacy of subcutaneous lidocaine injection in venous insufficiency: a prospective, randomized, controlled study, and new treatment protocol

“…Several studies have evaluated the efficacy of mesotherapy in the treatment of patients with CVI. Maggiori et al performed an intradermal administration of an agent with naturopathic component (Lymdiaral) and found that it was beneficial in reducing fibrosclerotic edema in patients with CVI 33 ) . Our study is the only study investigating the efficacy of subcutaneous lidocaine on pain and quality of life in patients with CVI.…”

A Call to Action by the Italian Mesotherapy Society on Scientific Research

“…Preliminary data indicate that mesotherapy allows for the management of signs and symptoms of chronic venous disease. 7 , 8 Evaluating the effects of this administration route in patients with chronic vascular damage would be worthwhile, in addition to assessing standard procedures for the management of skin lesions (eg diabetic or therapy resistant patients with skin ulcers).…”

“…[1][2][3] On the basis of this direction, LIT is used both to reduce localized pain and to manage patients with rehabilitation needs and sports injuries, especially when localized pain must be managed with the minimum effective drug dose. 4,5 Mesotherapy has also been applied to other fields, such as management of some signs and symptoms of chronic venous disease [6][7][8] and in some dermatological conditions. 9 In addition, LIT has been applied to manage some cases of skin ageing, such as wrinkling, loss of elasticity, laxity and rough-textured appearance.…”

Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects

“…For example, in chronic venous disease, the functional morphological alterations induced by the microcirculatory alteration, chronic edema, and fibrosclerosis could benefit from local treatment. Indeed, improvement of edema, pain control, ultrasound appearance, and satisfaction of patients have been reported in patients with chronic venous disease of the lower limbs treated with LIT [41,42]. ese results could be interpreted as rational to treat the edematous fibrosclerotic panniculitis (EFP) induced by microcirculatory dysfunction of the subcutaneous tissue, hypoxia, and local dystrophic phenomena of the dermis [43].…”