Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future

Levin, Yotam; Kochba, Efrat; Hung, Ivan; Kenney, Richard T.

doi:10.1080/21645515.2015.1010871

Cited by 92 publications

(73 citation statements)

References 103 publications

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“…In the past 10 years microneedles have been extensively investigated for delivery of drugs and vaccines by several groups [4–6] and more recently they are being explored as a diagnostic tool [7–9]. In the field of skin immunization microneedles have shown to present several immunological advantages when compared to conventional routes of delivery for vaccines against influenza [10, 6], Hepatitis B [11], malaria [12], polio [13], West Nile virus and Chikungunya [14] and a growing list of bacterial pathogens such as anthrax, diphtheria, tetanus, tuberculosis, botulism, plague, and staphylococcal toxin [15, 16].…”

Section: Introductionmentioning

confidence: 99%

Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature

Vassilieva

Kalluri

McAllister

et al. 2015

Drug Deliv. and Transl. Res.

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Prevention of seasonal influenza epidemics and pandemics relies on widespread vaccination coverage to induce protective immunity. In addition to a good antigenic match with the circulating viruses, the effectiveness of individual strains represented in the trivalent vaccines depends on their immunogenicity. In this study we evaluated the immunogenicity of H1N1, H3N2 and B seasonal influenza virus vaccine strains delivered individually with a novel dissolving microneedle patch and the stability of this formulation during storage at 25°C. Our data demonstrate that all strains retained their antigenic activity after incorporation in the dissolving patches as measured by SRID assay and immune responses to vaccination in BALB/c mice. After a single immunization all three antigens delivered with microneedle patches induced superior neutralizing antibody titers compared to intramuscular immunization. Cutaneous antigen delivery was especially beneficial for the less immunogenic B strain. Mice immunized with dissolving microneedle patches encapsulating influenza A/Brisbane/59/07 (H1N1) vaccine were fully protected against lethal challenge by homologous mouse-adapted influenza virus. All vaccine components retained activity during storage at room temperature for at least three months as measured in vitro by SRID assay and in vivo by mouse immunization studies. Our data demonstrate that dissolving microneedle patches are a promising advance for influenza cutaneous vaccination due to improved immune responses using less immunogenic influenza antigens and enhanced stability.

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Section: Introductionmentioning

confidence: 99%

Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature

Vassilieva

Kalluri

McAllister

et al. 2015

Drug Deliv. and Transl. Res.

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“…The MicronJet600 ® device used for ID injection was manufactured by NanoPass Technologies [30, 31]. It is a single-use, microneedle based device, for ID delivery of vaccines and other molecules into the skin.…”

Section: Methodsmentioning

confidence: 99%

Skin Vaccination against Rotavirus Using Microneedles: Proof of Concept in Gnotobiotic Piglets

et al. 2016

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Live-attenuated oral rotavirus (RV) vaccines have lower efficacy in low income countries, and additionally are associated with a rare but severe adverse event, intussusception. We have been pursuing the development of an inactivated rotavirus vaccine (IRV) using the human rotavirus strain CDC-9 (G1P[8]) through parenteral immunization and previously demonstrated dose sparing and enhanced immunogenicity of intradermal (ID) unadjuvanted IRV using a coated microneedle patch in comparison with intramuscular (IM) administration in mice. The aim of this study was to evaluate the immune response and protection against RV infection and diarrhea conferred by the administration of the ID unadjuvanted IRV using the microneedle device MicronJet600® in neonatal gnotobiotic (Gn) piglets challenged with virulent Wa G1P[8] human RV. Three doses of 5 μg IRV when administered intradermally and 5 μg IRV formulated with aluminum hydroxide [Al(OH)3] when administered intramuscularly induced comparable rotavirus-specific antibody titers of IgA, IgG, IgG avidity index and neutralizing activity in sera of neonatal piglets. Both IRV vaccination regimens protected against RV antigen shedding in stools, and reduced the cumulative diarrhea scores in the piglets. This study demonstrated that the ID and IM administrations of IRV are immunogenic and protective against RV-induced diarrhea in neonatal piglets. Our findings highlight the potential value of an adjuvant sparing effect of the IRV ID delivery route.

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“…Despite the immunological and economic advantages, ID administration using conventional needles and syringes shows technical difficulties. To overcome such drawbacks, easy‐to‐use delivery devices have been introduced, including an adapter for existing needles and syringes, a microneedle and a needle‐free jet injector . Among these devices, microneedles have been extensively exploited and clinically employed .…”

Section: Introductionmentioning

confidence: 99%

Enhanced immunity in intradermal vaccination by novel hollow microneedles

Ogai¹,

Nonaka²,

Toda³

et al. 2018

Skin Research and Technology

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Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future

Cited by 92 publications

References 103 publications

Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature

Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature

Skin Vaccination against Rotavirus Using Microneedles: Proof of Concept in Gnotobiotic Piglets

Enhanced immunity in intradermal vaccination by novel hollow microneedles

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