“…Since then, a wide variety of studies have reported the derivation of specific cell types from iPSCs, generating robust and reproducible phenotypes in vitro that reflect diseases intrinsic to the cellular level [ 35 ]. Specifically, evidence that reprogrammed cells can be differentiated into osteoblasts [ 54 , 55 , 56 ], chondrocytes [ 57 , 58 , 59 , 60 ], myoblasts [ 61 ], nucleus pulposus cells [ 47 , 48 , 49 ] and tenocytes [ 62 ] has recently impacted musculoskeletal research and changed orthopedic medicine. Nevertheless, the use of iPSCs for studying the wide variety of musculoskeletal conditions has been explored to a limited extent ( Table 1 ) in comparison with conditions affecting nervous or cardiac pathologies, even when investigating genetic disorders where symptoms affect several organs or systems [ 63 , 64 , 65 , 66 ].…”