Intraductal carcinoma of major salivary gland

Anderson, C. Russell; Muller, Richard C.; Piórkowski, Robert; Knibbs, David R.; Vignoti, Paul

doi:10.1002/1097-0142(19920201)69:3<609::aid-cncr2820690302>3.0.co;2-1

Cited by 65 publications

(37 citation statements)

References 19 publications

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“…In addition, SDC usually exhibits a high Ki-67 labeling index. Occasional cases of SDC in situ (SDCIS) have been described [15-17]. The in situ–like appearance or noninvasive cribriform growth pattern make it hard to distinguish between SDCIS and LGCCC.…”

Section: Discussionmentioning

confidence: 99%

Low-grade cribriform cystadenocarcinoma of salivary glands: report of two cases and review of the literature

et al. 2013

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Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described rare tumor of salivary gland which exhibits clinically indolent behavior. This tumor predominantly consists of intraductal components and frequently exhibits papillary-cystic or cribriform proliferation pattern. Considering the histological features of LGCCC, it should be distinguished with papillocystic variant of acinic cell carcinoma, conventional salivary duct carcinoma, cystadenocarcinoma, polymorphous low-grade adenocarcinoma, carcinoma ex pleomorphic adenoma and mammary analogue secretory carcinoma. Herein, we presented two cases of LGCCC. One arose in the left parotid region in a 48-year-old male, and the other one arose in the right parotid gland in a 59-year-old female. For both cases, immunohistochemically, the luminal tumor cells showed diffuse expression of CK and S100; p63 and smooth muscle actin displayed a continuous rim of myoepithelial cells around all tumor islets; no myoepithelial cells were admixed with the luminal cells. Both patients were alive with no tumor recurrence or metastasis at follow-up.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2593621568999135

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Section: Discussionmentioning

confidence: 99%

Low-grade cribriform cystadenocarcinoma of salivary glands: report of two cases and review of the literature

et al. 2013

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“…Although not formally recognized in the 2005 edition of the WHO Classification of Head and Neck Tumors, there are rare but well documented cases of ''high grade intraductal'' carcinomas of salivary glands [26][27][28] or ''salivary duct carcinoma in situ'' [29]. High-grade intraductal carcinoma/salivary duct carcinoma in situ (HG-IDC) share with LG-SDC many features including partly cystic appearance, cribriform, solid, and micropapillary patterns, and neoplastic cells with ductal phenotype-including apocrine differentiation-surrounded by an attenuated layer of myoepithelial cells.…”

Section: Cystadenocarcinomamentioning

confidence: 99%

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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Low-grade salivary duct carcinoma (LG-SDC) is a rare neoplasm characterized by predominant intraductal growth, luminal ductal phenotype, bland microscopic features, and favorable clinical behavior with an appearance reminiscent of florid to atypical ductal hyperplasia to low grade intraductal breast carcinoma. LG-SDC is composed of multiple cysts, cribriform architecture with ''Roman Bridges'', ''pseudocribriform'' proliferations with floppy fenestrations or irregular slits, micropapillae with epithelial tufts, fibrovascular cores, and solid areas. Most of the tumor cells are small to medium sized with pale eosinophilic cytoplasm, and round to oval nuclei, which may contain finely dispersed or dark condensed chromatin. Foci of intermediate to high grade atypia, and invasive carcinoma or micro-invasion have been reported in up to 23 % of cases. The neoplastic cells have a ductal phenotype with coexpression of keratins and S100 protein and are surrounded by a layer of myoepithelial cells in noninvasive cases. The main differential diagnosis of LG-SDC includes cystadenoma, cystadenocarcinoma, sclerosing polycystic adenosis, salivary duct carcinoma in situ/highgrade intraductal carcinoma, and papillary-cystic variant of acinic cell carcinoma. There is no published data supporting the continuous classification of LG-SDC as a variant of cystadenocarcinoma. Given that most LG-SDC are noninvasive neoplasms; the terms ''cribriform cystadenocarcinoma'' and LG-SDC should be replaced by ''low-grade intraductal carcinoma'' (LG-IDC) of salivary gland or ''lowgrade intraductal carcinoma with areas of invasive carcinoma'' in those cases with evidence of invasive carcinoma.

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“…Prognostically favorable pathologic observations include an intraductal component comprising greater than 90% of the tumor and smaller tumor size of less than 2-3 centimeters (95,96). Discrimination from the rarely reported purely intraductal high grade carcinoma may require immunohistochemistry to clarify (78,79).…”

Section: Salivary Duct Carcinomamentioning

confidence: 99%