“…We have read the comments made by Drs Kryvenko and Epstein1 on the report of our study relating to nuclear size in lesions diagnosed as intraductal carcinoma of the prostate (IDCP) 2. In this study we utilized image analysis to examine 10,000 nuclei to show that the diagnostic criterion of extreme nuclear size, as proposed by Guo and Epstein,3 was not observed.…”