Intraductal (intracystic) papillary carcinoma of the breast and its variants: A clinicopathological study of 77 cases

Lefkowitz, Martin; Lefkowitz, William; Wargotz, Eric S.

doi:10.1016/0046-8177(94)90250-x

Cited by 157 publications

(129 citation statements)

References 14 publications

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“…Of these, adenosis and intraductal papilloma with sclerosis are sometimes difficult to differentiate from invasive ductal carcinoma (2). Distinction between some intracystic papillary carcinomas (3,4) with low nuclear grade and intraductal papilloma are challenging. A two-cell pattern of epithelial and myoepithelial cells is maintained even in such problematic lesions, except in one special type of adenosis called "microglandular adenosis" (5,6).…”

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confidence: 99%

Availability of CD10 Immunohistochemistry as a Marker of Breast Myoepithelial Cells on Paraffin Sections

et al. 2002

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CD10, also called common acute lymphoblastic leukemia antigen (CALLA), was recently found to be expressed in nonhematopoietic tissues. Although CD10 was also identified in human breast myoepithelial cells, its availability of immunohistochemistry on paraffin sections has not been examined so far. In the present study, we demonstrated CD10 immunohistochemically on paraffin sections of both normal and pathological breast tissues, comparing its staining patterns to those of smooth muscle actin (SMA), which is now commonly used to highlight myoepithelium. CD10 was consistently positive in normal breast myoepithelial cells. CD10 also clearly highlighted myoepithelial cells in intraductal papilloma, adenosis, ductal hyperplasia, fibroadenoma, and phyllodes tumor as well as SMA did. In atypical ductal hyperplasia and ductal carcinoma in situ, continuous, discontinuous, and totally negative stainings of both CD10 and SMA were noted, depending on foci of neoplastic cell nests. However, both stainings clearly demonstrated myoepithelial cells of cancerized acini, being useful in differentiating lobular cancerization from microinvasion. Because SMA was also positive in normal vessels and spindle-shaped stromal cells, CD10, which was negative in vessels, was useful in differentiating myoepithelial cells from thin vascular wall in intracystic lesions with delicate papillae. Although background staining of spindle-shaped stromal cells was also noted in CD10, the positive cell number was less, and the signal was weaker than that of SMA. The absence of myoepithelial cells in invasive ductal carcinomas was more clearly highlighted by CD10 than SMA. We concluded that CD10 could be another useful marker of breast myoepithelial cells on paraffin sections. Combination of CD10 and SMA will provide more sophisticated information about presence or absence of myoepithelial cells in confusing breast lesions.

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confidence: 99%

Availability of CD10 Immunohistochemistry as a Marker of Breast Myoepithelial Cells on Paraffin Sections

et al. 2002

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“…Prognosis is usually excellent with disease free 10 year survival rates being reported as 91 % and overall survival at 10 years as 100 % in one study [8].…”

Section: Discussionmentioning

confidence: 94%

Papillary Carcinoma of the Breast- Case Reports and Review of Literature Regarding Management Guidelines

et al. 2012

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Papillary carcinoma of the breast is a very rare entity accounting for approx 1 % of all breast carcinomas. The diagnosis is difficult due to different clinical and radiological features. Pathological diagnosis is conclusive. Being aware of the diagnostic difficulties and differences in management from the more commonly reported IDC, makes it easier to treat these patients. Because this is an uncommon disease, we report here 2 cases recently diagnosed and treated in our hospital. We have also reviewed the literature regarding the diagnosis, treatment and prognosis of these patients.

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“…Generally, it is accepted as a non-invasive breast cancer and as a low-grade DCIS subtype, however, there are classifications where it is regarded as invasive breast carcinoma (2). The presence of myoepithelial cells around papillary carcinoma is considered as a sign of invasive focus rather than in situ tumor (8).…”

Section: Discussionmentioning

confidence: 99%

“…However, recent studies where myoepithelial cells were not detected around papillary carcinoma with DCIS created doubts on the presence of another type of IPC between in situ and invasive forms (8,9). The rate of invasive focus is reported as 40% in many series, although it may vary (2,8,10). The rate of lymph node metastases range between 0-36%, and is much lower than that in normal breast cancer (3).…”

Section: Discussionmentioning

confidence: 99%

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Intracystic Carcinoma of the Breast: Report of Two Cases

et al. 2015

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Intracystic papillary carcinoma of the breast (IPC) is usually seen in postmenopausal elderly women. Its prognosis is much better than other type of breast tumors, and usually do not contain invasive components. Surgical excision with negative margins and axillary sentinel lymph node sampling is the recommended treatment. Two cases of intracystic papillary carcinoma of the breast that was treated at our clinic are herein presented. Both cases were postmenopausal, were both positive for estrogen and progesterone receptors and negative for HER 2. They underwent breast-conserving surgery. One patient had an invasive focus, therefore axillary lymph node sampling was performed, and the sentinel lymph node was not metastatic. This patient received hormonal therapy as well as radiotherapy. In the other case, there was no invasive focus and the surgical margins were negative, therefore, additional surgery was not performed. The patient is receiving hormonal therapy. Intracystic carcinoma of the breast should be kept in mind especially in elderly patients with breast cysts, with clinically or radiologically suspicious features, and biopsy and local excision should be considered. Although there is not any standard approach for patients with IPC, each patient must be evaluated for surgery and should be individually assessed in terms of adjuvant therapy

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Intraductal (intracystic) papillary carcinoma of the breast and its variants: A clinicopathological study of 77 cases

Cited by 157 publications

References 14 publications

Availability of CD10 Immunohistochemistry as a Marker of Breast Myoepithelial Cells on Paraffin Sections

Availability of CD10 Immunohistochemistry as a Marker of Breast Myoepithelial Cells on Paraffin Sections

Papillary Carcinoma of the Breast- Case Reports and Review of Literature Regarding Management Guidelines

Intracystic Carcinoma of the Breast: Report of Two Cases

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