Intraductal Pancreatic Neuroendocrine Tumor

Chetty, Runjan; El-Shinnawy, Ihab

doi:10.1007/s12022-009-9093-z

Cited by 22 publications

(11 citation statements)

References 17 publications

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“…PETs can occur throughout the pancreas, and vary in size from <10 mm to well over 50 mm. Intraductal location is exceptionally rare 14 …”

Section: Grossmentioning

confidence: 99%

Endocrine tumours of the pancreas

Verbeke

2010

Histopathology

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Verbeke C S (2010) Histopathology 56, 669-682 Endocrine tumours of the pancreas Histopathology reporting of pancreatic endocrine neoplasms is complex. The tumours can exhibit a variety of morphological appearances, which often require careful differential diagnostic consideration. Prediction of tumour behaviour and clinical outcome is based on the World Health Organization classification and TNM staging and grading system, which share some criteria and premises, but differ significantly in others. Clinicopathological correlation through discussion at multidisciplinary team meetings is of paramount importance. In this review special emphasis is given to the items of information that can and should be provided by the pathologist to allow optimal patient management. The review further discusses areas of current controversy and uncertainty, of which pathologists participating in multidisciplinary discussions should be aware.

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“…PETs can occur throughout the pancreas, and vary in size from <10 mm to well over 50 mm. Intraductal location is exceptionally rare 14 …”

Section: Grossmentioning

confidence: 99%

Endocrine tumours of the pancreas

Verbeke

2010

Histopathology

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“…In this situation, the clinical presentation and the pathological features are usually very different from those associated with our cases: (a) the clinical picture is usually severe, with symptomatic acute or chronic pancreatitis; (b) the endocrine tumor is usually large; (c) its histological and morphological characteristics lie within the spectrum of conventional pancreatic neuroendocrine tumors; (d) direct infiltration of the excretory duct by tumor cells is not constant; when it occurs, it clearly results from the entrapment of the excretory duct by a primarily intra-parenchymal tumor [5]; (e) most of these tumors behave as malignant tumors and present with lymph node and/or distant metastases at diagnosis [21]. The second situation is represented by the rare cases of pancreatic endocrine tumors with intra-ductal growth [22][23][24][25][26][27][28][29][30][31][32], defined by the presence of a large intraluminal tumor mass, obliterating the lumen of an excretory duct, which may be isolated or, more commonly, connected to an adjacent intra-parenchymal mass. Any of our cases was associated with an intra-luminal component.…”

Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine tumors of the main pancreatic duct: a rare entity

et al. 2011

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Very few cases of primary neuroendocrine tumors of the main pancreatic duct have been reported. This paucity has hampered an accurate description of the distinctive clinical and pathological features of these tumors and the correct evaluation of the diagnostic and therapeutic problems which they may raise. We report here five additional cases in order to underline the clinical, histological, and immunohistochemical features of this tumor entity. There were three male and two female, aged 43-72 years; in all patients, but one, who presented with epigastric pain, the diagnosis was made after the incidental discovery of a dilatation of the main pancreatic duct. The preoperative diagnosis was ductal adenocarcinoma in one case, IPMN in one case and neoplastic stenosis of unknown etiology in four cases. Surgical resection was performed in all cases. The diagnosis of neuroendocrine tumor was made at histological examination. All lesions were small, ranging from 5 to 15 mm. They had a predominantly intramural growth. The growth pattern was nodular in three cases, circumferential in two; there was no intra-luminal component. All cases were well-differentiated neuroendocrine neoplasms of low histological grade (G1); four cases expressed serotonin. One case was associated with regional lymph node metastases. All cases were cured by surgery alone; no recurrence was observed at the end of the follow-up period. In conclusion, despite their rarity, primary neuroendocrine tumors of the main pancreatic duct deserve recognition and must be considered in the etiological diagnosis of ductal stenosis.

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“…Histologically, the tumor was composed of atypical cells with round nuclei arranged within small nests and cords, and immunopositivity for synaptophysin and chromogranin A. . Chetty et al 3) noted that such tumors are morphologically distinctive and that diagnostic problems are scarce despite their rarity, with one of the unusual features of pancreatic NET being tumor growth predominantly within the main pancreatic duct. The few cases reported in the literature have been divided into two categories 3) : those showing intraductal tumor accompanied by a pancreatic parenchymal component, and those comprising purely intraductal pancreatic NET (without a parenchymal component).…”

Section: Clinical Datamentioning

confidence: 99%

“…Chetty et al 3) noted that such tumors are morphologically distinctive and that diagnostic problems are scarce despite their rarity, with one of the unusual features of pancreatic NET being tumor growth predominantly within the main pancreatic duct. The few cases reported in the literature have been divided into two categories 3) : those showing intraductal tumor accompanied by a pancreatic parenchymal component, and those comprising purely intraductal pancreatic NET (without a parenchymal component). In the former case, the NET arising in the vicinity of the main pancreatic duct could grow into and along the duct, while the latter type might theoretically have derived from totipotential stem cells located in the epithelium of major ducts 4) .…”

Section: Clinical Datamentioning

confidence: 99%

Neuroendocrine tumor within main pancreatic duct: a case report

Munekage

Maeda

Namikawa

et al. 2017

Ann. Cancer Res. Therap.

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Background: Pancreatic neuroendocrine tumor (NET) is a well-known, but uncommon disease that manifests as a heterogeneous, intense, round mass on enhanced computed tomography (CT). Herein, we report a case of pancreatic NET with unusual CT manifestation. A 66-year-old female was referred to our hospital for treatment of intermittent back pain. CT revealed a diffusely swollen pancreas from the head to tail. Imaging enhancement was weak except for a small area at the pancreatic head, and the lumen of the main pancreatic duct seemed narrowed. The entire pancreas showed accumulation of fluoro-D-glucose (FDG) on positron emission tomography (PET), suggesting autoimmune pancreatitis; however, endoscopic ultrasound-fine needle aspiration revealed atypical cells with round nuclei in a rosette formation, resulting in a diagnosis of non-functioning NET. Pathological examination revealed tumor growth within the main pancreatic duct with large areas of necrosis, and an area of viable cells at the head of the pancreas. In conclusion, CT imaging depicted an NET within the main pancreatic duct as a diffusely enlarged pancreas mimicking autoimmune pancreatitis.

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Intraductal Pancreatic Neuroendocrine Tumor

Cited by 22 publications

References 17 publications

Endocrine tumours of the pancreas

Endocrine tumours of the pancreas

Primary neuroendocrine tumors of the main pancreatic duct: a rare entity

Neuroendocrine tumor within main pancreatic duct: a case report

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