Intradural–extramedullary haemangioblastoma with paraspinal extension in a dog

Binanti, Diana; Fantinato, Eleonora; Allevi, Giovanni; Sironi, G.; Zani, D. De

doi:10.1111/avj.12376

Cited by 10 publications

(16 citation statements)

References 27 publications

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“…Nonetheless, thus far, only 20 publications of clinical studies investigating metronomic drug delivery in small animals with cancer have been published. From these studies, 5 are case reports, and 15 provide data from a series of dogs . Only these last ones will be discussed in this work and can be found summarized in Table .…”

Section: Clinical Studies In Veterinary Medicinementioning

confidence: 99%

The use of low‐dose metronomic chemotherapy in dogs—insight into a modern cancer field

Gaspar

Henriques

Marconato

et al. 2017

Vet Comparative Oncology

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The era of chemotherapy, which started in the middle of the last century, has been ruled by the routine use of dose-intense protocols, based on the "maximum-tolerated dose" concept. By promoting a balance between patient's quality of life and the goal of rapidly killing as many tumour cells as possible, these protocols still play a prominent role in veterinary oncology.However, with the opening of a new millennium, metronomic chemotherapy (MC) started to be considered a possible alternative to traditional dose-intense chemotherapy. Characterized by a long-term daily administration of lower doses of cytotoxic drugs, this new modality stands out for its unique combination of effects, namely on neovascularization, immune response and tumour dormancy. This article reviews the rationale for treatment with MC, its mechanism of action and the main studies conducted in veterinary medicine, and discusses the key challenges yet to be solved. K E Y W O R D Schemotherapy, cytotoxic drugs, dogs, dose-intense, metronomic, review

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Section: Clinical Studies In Veterinary Medicinementioning

confidence: 99%

The use of low‐dose metronomic chemotherapy in dogs—insight into a modern cancer field

Gaspar

Henriques

Marconato

et al. 2017

Vet Comparative Oncology

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“…Haemangioblastomas are histologically characterised by the presence of lipid‐containing interstitial stromal cells and a large number of randomly orientated capillary networks lined by endothelial cells. The stromal cells are considered the neoplastic component of the disease 8 …”

Section: Discussionmentioning

confidence: 99%

“…Surgical en bloc resection of the spinal cord haemangioblastoma in dogs has been reported to have an excellent long‐term outcome 1 . In two case reports, repeat MRI assessment following surgical resection of the tumour did not identify recurrence 9 and 12 months postoperatively 1,8 . In human medicine, resection of intramedullary spinal haemangioblastomas via microsurgery has resulted in good neurological outcome in 80% of patients 9 .…”

Section: Discussionmentioning

confidence: 99%

Long‐term outcome of a dog with surgically resected thoracic intramedullary haemangioblastoma and concurrent lumbosacral disease

Jerram²,

Hoddinott

2022

Vet Record Case Reports

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A 5‐year‐old male, neutered, English Bulldog presented for acute progressive paraparesis. Neurological examination revealed a weak withdrawal reflex in the left pelvic limb and lumbosacral pain, suggestive of a L4–S3 myelopathy. Magnetic resonance imaging revealed an incidental intramedullary mass at the T9 vertebra and L7–S1 intervertebral disc protrusion with bilateral foraminal stenosis. The dog was treated with epidural methylprednisolone. Repeat neurological examination postepidural revealed normal withdrawal reflexes and resolution of lumbosacral spinal pain. However, progressive paraparesis, thoracolumbar pain and epaxial muscle atrophy were evident. A T3–L3 myelopathy was suspected secondary to the intramedullary mass. The mass was surgically resected, and histology revealed haemangioblastoma. Neurological status improved initially, but deteriorated later due to the lumbosacral disease. The dog improved following repeat methylprednisolone epidural injection, but remained paraparetic. This case report is consistent with previous literature and provides additional information on the treatment and prognosis of spinal cord haemangioblastoma with concurrent lumbosacral disease.

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“…A case report describes the diagnosis and treatment of a rare intradural–extramedullary haemangioblastoma in a dog that had a 2‐month history of thoracic limb weakness . Neurological examination identified mild ataxia and delayed proprioception in all limbs.…”

Section: Small Animalsmentioning

confidence: 99%

In this issue – December 2015

Jackson¹

2015

Aust Veterinary J

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Intradural–extramedullary haemangioblastoma with paraspinal extension in a dog

Cited by 10 publications

References 27 publications

The use of low‐dose metronomic chemotherapy in dogs—insight into a modern cancer field

The use of low‐dose metronomic chemotherapy in dogs—insight into a modern cancer field

Long‐term outcome of a dog with surgically resected thoracic intramedullary haemangioblastoma and concurrent lumbosacral disease

In this issue – December 2015

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