Intradural lumbosacral malignant extrarenal rhabdoid tumor: a case report

Garling, Richard Justin; Singh, Rasanjeet; Harris, Carolyn A.; Haridas, Abilash

doi:10.1007/s00381-017-3571-2

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…The histologic morphology of liver MRT, a rare subtype that portends a grim prognosis, is consistent with that of rhabdoid tumor in the kidney, and its histological origin is unclear [1]. Infants and young children are the main population of liver MRT.…”

Section: Discussionmentioning

confidence: 96%

Malignant rhabdoid tumor of the liver in a middle-aged woman: a case report and literature review

Liu

Zhang

2022

BMC Gastroenterol

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Background Extrarenal malignant rhabdoid tumor (EMRT) is a rare and high-mortality malignant tumor, which is more common in infants and rarely seen in adults. We firstly report a case of liver malignant rhabdoid tumor (MRT) with a loss of SMARCB1 gene (alias INI1, SNF5, BAF47) expression in a middle-aged woman, and preliminarily summarize the clinical characteristics and discuss its potential treatment of liver MRT by reviewing 55 cases reported in the past. Case presentation We report a 40-year-old woman who was admitted to our hospital for right epigastric pain. Previously, the patient was treated with liver hematoma in another hospital until she came to our hospital for abdominal pain again. In our hospital, we performed surgical treatment on her and the pathology diagnosed EMRT with negative expression of SMARCB1. After surgery, the patient underwent genetic testing, but failed to screen for sensitive targeted or conventional chemotherapy drugs, and she did not receive further treatment. Due to lack of timely diagnosis and effective chemotherapy drugs, tumor recurrence and metastasis occurred one year after surgery. Then the patient chose traditional Chinese medicine for treatment. And the metastatic tumors had still progressed after one year of treatment, but the patient didn’t have obvious discomfort symptoms. Conclusions Liver MRT is a highly aggressive tumor with high metastatic potential and poor prognosis. It lacks specific symptoms and signs and is easy to be ignored and misdiagnosed. The mortality rate is extremely high as there is no effective treatment. But most tumors are accompanied by SMARCB1 deficiency, which may offer new research directions for cancer therapeutics. For the present, early detection, early diagnosis and early resection remain the key to improve the prognosis of patients.

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Section: Discussionmentioning

confidence: 96%

Malignant rhabdoid tumor of the liver in a middle-aged woman: a case report and literature review

Liu

Zhang

2022

BMC Gastroenterol

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“…According to the location of the tumor, it can be divided into three types: malignant rhabdoid tumor of the kidney (MRTK), central nervous system atypical teratoid/rhabdoid tumor, and extrarenal extracranial rhabdoid tumor (EERT) ( 11 ). Malignant rhabdoid tumors are common among infants and children, and the non-kidney ones have a wide range of age and can occur in adults, but there are more cases in infants and children; EERT cases are mostly common among late adolescence or young people ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: A rare case of omental extrarenal rhabdoid tumor and review of the literature

Li,

Wen,

et al. 2024

Front. Oncol.

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Extrarenal rhabdoid tumor of the greater omentum is extremely rare, with only sporadic reports and limited documentation of its ultrasonographic findings. Here, we report a case of an extrarenal rhabdoid tumor of the greater omentum in a 16-year-old girl and review the relevant literature. It was found that the disease mainly occurred in female children and adolescents, and mainly manifested as lower abdominal pain and a large abdominal cystic or solid hemorrhagic mass. The clinical characteristics include a high degree of malignancy and mortality. Ultrasound shows some malignant features, but it is not specific; thus, it is easy to be misdiagnosed in the clinic.

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“…The frequency of AT/RT occurrence in the cauda equina is extremely low. To the best of our knowledge, only eight cases have been reported in the English literature (Table 1), [11][12][13][14][15][16][17][18] with a slight male predominance (66.7%) and a median age of 18 months at diagnosis. All patients underwent surgery, with subtotal resection in four cases, partial resection in one, and biopsy in one.…”

Section: Discussionmentioning

confidence: 99%

“…8,10 In addition, pediatric AT/RT of the cauda equina is extremely rare, and only eight cases have been reported in the English-language literature. [11][12][13][14][15][16][17][18] Owing to its rarity, the clinical behavior and optimal treatment are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Pediatric atypical teratoid/rhabdoid tumor in the cauda equina with rapid tumor progression: A case report and review of the literature

Ohno,

Tsuchiya,

Watanabe

et al. 2024

Preprint

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Atypical teratoid/rhabdoid tumors (AT/RT) rarely occur in the cauda equina; thus, the clinical behavior and optimal treatment remain unclear. A 9-year-old boy presented with a rapidly progressing intradural extramedullary tumor at the L2–5 level, underwent tumor resection, and was diagnosed with AT/RT. His gait disturbance improved postoperatively, and he received adjuvant chemotherapy and radiotherapy. In 5 months of follow-up, recurrence was not observed. Although extremely rare, AT/RT should be included in the differential diagnosis, as it requires prompt therapeutic intervention. Safe resection with minimal functional impairment, followed by postoperative chemoradiation, can lead to tumor control and improve neurological function.

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Intradural lumbosacral malignant extrarenal rhabdoid tumor: a case report

Abstract: To our knowledge, there are no previous case reports of MERT with intradural lumbosacral spinal involvement.

Cited by 6 publications

References 13 publications

Malignant rhabdoid tumor of the liver in a middle-aged woman: a case report and literature review

Malignant rhabdoid tumor of the liver in a middle-aged woman: a case report and literature review

Case report: A rare case of omental extrarenal rhabdoid tumor and review of the literature

Pediatric atypical teratoid/rhabdoid tumor in the cauda equina with rapid tumor progression: A case report and review of the literature

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