Intradural spinal granular cell tumor

Abstract

Granular cell tumor is a rare, usually benign tumor with classical histomorphology. Location of tumor varies widely within body, but spine is distinctly a rare location for this tumor. We report a rare case of granular cell tumor involving intradural extramedullary portion of lumbar region of spinal cord. Knowledge of which is important as subsequent prognosis differs from other tumor at same location.

Intradural extramedullary granular cell tumour in a cat

“…In this case we found strong positive immunoexpression of NSE and S-100 (markers for neuronal origin) and desmin (marker for muscle origin). Concomitant S-100 and NSE positivity has already been reported in two canine GCTs (Liu et al 2004, Rao et al 2010, and documented in human GCTs (Takayama et al 2004, Weinstein et al 2010, Vaghasiya et al 2014. This immunohistochemical pattern seems to support a Schwann cell origin of these tumours (Takayama et al 2004, Rekhi & Jambhekar 2010.…”

“…While the previous two cases of canine spinal GCT (Montoliu et al 2006, Rao et al 2010 were extradurally located, in our case the localisation was intradural-extramedullary. Analogously, this localisation seems to be the most frequent in human spinal GCTs (Takayama et al 2004, Weinstein et al 2010, Vaghasiya et al 2014. Due to the localisation of the tumour, a potential differential diagnosis of meningioma showing a consistent granular cell component (Patnaik 1993, Mandara et al 2006) and rhabdoid differentiation (Schoniger et al 2013, Louis et al 2016 should also be considered.…”

Recurrent granular cell tumor: a case report and review of literature

“…Literature review shows they have a low proliferative index (<3%). Apart from our case (Mib index <1-2%), Pj et al (12) and Vaghasiya et al (13) did Mib index sampling which were very low (<1-3% and <1% respectively), suggesting benign nature of the tumor.…”

Granular cell tumors in the central nervous system: a report on eight cases and a literature review

“…1 They most commonly occur in the skin, head, and neck, with a particular predisposition for the tongue. 2 Although GCTs in the central nervous system (CNS) are extremely rare, when present, they exhibit a slight predilection for occurrence in the posterior hypophysis and cerebral hemispheres. 3,4 They can also be found in the cranial nerves as well as within the spinal canal.…”