Intraepidermal neutrophilic IgA/IgG antidesmocollin 1 pemphigus

Heng, Aaron H S; Nwaneshiudu, Adaobi I.; Hashimoto, Takashi; Amagai, Masayuki; Stanley, John R.

doi:10.1111/j.1365-2133.2006.07226.x

Cited by 29 publications

(18 citation statements)

References 8 publications

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“…[3,4] IgG/IgA pemphigus has been reported to show IgG and IgA reactivity with Dsg1 and/or Dsg3, [4][5][6] or with Dsc1. [7,8] Kozlowska et al reported a case of IgG/IgA pemphigus with clinical features of pemphigus herpetiformis and IgG and IgA reactivity with Dsg1 with additional IgG reactivity to Dsc1. [9] Pemphigus herpetiformis show IgG reactivity frequently with Dsg1 and occasionally with Dsg3.…”

Section: Discussion Discussionmentioning

confidence: 99%

IgG/IgA pemphigus reactive with desmoglein 1 with additional undetermined reactivity with epidermal basement membrane zone

Kanwar¹,

Vinay²,

Saikia³

et al. 2014

Indian J Dermatol Venereol Leprol

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IgG/IgA pemphigus is an extremely rare subset of pemphigus, showing anti-keratinocyte cell surface antibodies of both IgG and IgA classes. Herein, we describe a unique case of IgG/IgA pemphigus with clinical features of edematous erythema and peripheral vesiculopustules. Histopathology showed the presence of subcorneal pustules and acantholytic blisters in the mid-epidermis with neutrophilic infiltration and eosinophilic spongiosis. Direct immunofluorescence of perilesional skin showed both IgG and IgA deposits to keratinocyte cell surfaces and unusual granular deposits of IgG, IgM, and C3 along basement membrane zone. On enzyme linked immunosorbent assay , the auto-antibodies were found to be reactive to desmoglein 1 antigen. Various clinical, histopathological, and immunological findings in our case overlapped with the features of IgA pemphigus, pemphigus herpetiformis, and pemphigus foliaceus. These findings indicate that IgG/IgA pemphigus may be a transitional form between IgA pemphigus and pemphigus herpetiformis, and thus provides insight into the pathogenicity of this rare disorder.

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Section: Discussion Discussionmentioning

confidence: 99%

IgG/IgA pemphigus reactive with desmoglein 1 with additional undetermined reactivity with epidermal basement membrane zone

Kanwar¹,

Vinay²,

Saikia³

et al. 2014

Indian J Dermatol Venereol Leprol

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“…A new rare atypical pemphigus, characterized by the coexistence of circulating anti‐keratinocyte cell surface antibodies of both IgG and IgA classes, which manifests with neutrophilic acantholysis and epidermal intercellular IgG and IgA deposits, has been recently termed as IgG/IgA pemphigus 1–10 . We describe two new cases of IgG/IgA pemphigus with desmoglein 1 (Dsg1) identified by enzyme‐linked immunosorbent assay (ELISA) as the exclusive target antigen.…”

mentioning

confidence: 99%

“…Fourteen cases of IgG/IgA pemphigus have been reported 1–10 . IgG/IgA pemphigus might be the transitional form between pemphigus herpetiformis and IgA pemphigus 5 or a very uncommon atypical form of pemphigus.…”

mentioning

confidence: 99%

IgG/IgA pemphigus with IgA and IgG antidesmoglein 1 antibodies detected by enzyme-linked immunosorbent assay: presentation of two cases

Santiago-et-Sánchez-Mateos

Martin

Arriba

et al. 2010

Journal of the European Academy of Dermatology and Venereology

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“…Interestingly, subcorneal pustular dermatosis, a subset of IgA pemphigus with anti‐DSC1 IgA autoantibodies, is characterized by a strong neutrophilic inflammatory response, which accompanies blister formation, a feature similar to that seen in canine PF . In addition, anti‐DSC1 IgA antibodies were uncovered in atypical forms of pemphigus foliaceus where neutrophilic inflammation is also a prominent feature of blister formation …”

Section: Introductionmentioning

confidence: 95%

Serum autoantibody profiles of IgA, IgE and IgM in canine pemphigus foliaceus

Bizikova

Olivry

Mamo

et al. 2014

Veterinary Dermatology

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Our findings suggest that sera from dogs with PF rarely contain IgA or IgE autoantibodies at levels detectable by indirect immunofluorescence, while IgM autoreactivity appears not to be a feature of this disease. Considering these findings, it appears that canine PF is aetiologically and immunologically similar to that of the classic human PF, in which the IgG autoantibody response is also the predominant type.

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Intraepidermal neutrophilic IgA/IgG antidesmocollin 1 pemphigus

Cited by 29 publications

References 8 publications

IgG/IgA pemphigus reactive with desmoglein 1 with additional undetermined reactivity with epidermal basement membrane zone

IgG/IgA pemphigus reactive with desmoglein 1 with additional undetermined reactivity with epidermal basement membrane zone

IgG/IgA pemphigus with IgA and IgG antidesmoglein 1 antibodies detected by enzyme-linked immunosorbent assay: presentation of two cases

Serum autoantibody profiles of IgA, IgE and IgM in canine pemphigus foliaceus

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