Intraepithelial Lymphocyte Counts in Small Intestinal Biopsies From Children With Diarrhoea

Ferguson, Anne; McClure, Jo-Ann; Townley, R. R. W.

doi:10.1111/j.1651-2227.1976.tb04929.x

Cited by 89 publications

(48 citation statements)

References 13 publications

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“…A number of studies have identified associations with giardiasis, small-intestine bacterial overgrowth, and other infective enteritities. [19][20][21][22] Tropical sprue has also been associated with Marsh I lesions. Marsh et al 23 describe increased levels of IELs in patients with tropical sprue.…”

Section: Specificity Of the Marsh I Lesionmentioning

confidence: 99%

The Clinical Significance of Duodenal Lymphocytosis With Normal Villus Architecture

Hammer

Greenson

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The finding of increased intraepithelial lymphocytes with normal villous architecture (Marsh I lesion) is seen in up to 3% of duodenal biopsies. The differential diagnosis includes a wide range of possibilities, including celiac disease, bacterial overgrowth, nonsteroidal antiinflammatory drug damage, reaction to Helicobacter pylori infection, tropical sprue, and chronic inflammatory bowel disease.Objectives.-To highlight the histologic features of the Marsh I lesion, review the diseases and conditions associated with that finding, and to provide pathologists with a rationale and a template for how to identify and report such cases.Data Sources.-A review of the literature regarding the histologic features and clinical associations of Marsh I lesions.Conclusions.-Marsh I lesions are a nonspecific finding associated with a number of disease conditions. Historically, between 9% and 40% of cases have been shown to represent celiac disease. Current data do not suggest histologic features to differentiate between diseases associated with this histologic change.

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Section: Specificity Of the Marsh I Lesionmentioning

confidence: 99%

The Clinical Significance of Duodenal Lymphocytosis With Normal Villus Architecture

Hammer

Greenson

2013

Archives of Pathology &Amp; Laboratory Medicine

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“…Intestinal epithelial cells (IEC) 3 play an important role for the immune response within the intestinal tract. This immunoregulatory role of IEC is mediated through interactions with intestinal intraepithelial lymphocytes.…”

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confidence: 99%

ADAM-15/Metargidin Mediates Homotypic Aggregation of Human T Lymphocytes and Heterotypic Interactions of T Lymphocytes with Intestinal Epithelial Cells

Charrier

Yan

Nguyen

et al. 2007

Journal of Biological Chemistry

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Intestinal epithelial cells (IEC)3 play an important role for the immune response within the intestinal tract. This immunoregulatory role of IEC is mediated through interactions with intestinal intraepithelial lymphocytes. The interactions between IEC and intraepithelial lymphocytes are thought to mediate T cell recruitment to intestinal epithelia (1). In particular, cell-to-cell interactions are believed to stabilize the retention of lymphocytes within intestinal epithelia (2), thus leading to the formation of an immune barrier against intestinal pathogens. However, aberrant cell adhesion has been implicated in the pathogenesis of a number of inflammatory disorders, including inflammatory bowel disease (IBD). Among immune cells recruited during intestinal inflammation, T lymphocytes may play a role in the pathogenesis of various intestinal diseases including Crohn disease and ulcerative colitis. Indeed some intestinal diseases show increased intraepithelial lymphocytes (i.e. celiac disease, lymphocytic colitis, tropical sprue, and giardiasis) and/or phenotypic alteration of intraepithelial lymphocytes (celiac disease, Crohn disease, and ulcerative colitis) (3-11). Most descriptions of early Crohn disease lesions include mucosal lymphoid aggregates (12-16) that are mainly composed of T cells and that may contribute to the pathogenesis of Crohn disease (15). Thus, it is interesting to consider the cell-cell interactions involved in IBD and possible strategies for therapeutic modulation.Only a few molecular interactions have been identified that are involved in the specific retention of lymphocytes in intestinal epithelia. It has been shown that adherence of T lymphocytes to human epithelial cell lines can be mediated through LFA-1 and ICAM-1 (17-19). CD1d, expressed on IEC, mediates T cell-IEC interactions (20). Cell-cell and cell-fusion protein adhesion assays showed that ␣E␤7 integrin expressed on T cells mediates T lymphocytes/IEC adhesion via E-cadherin (2,(21)(22)(23)(24)(25)(26). N-cadherin has also been shown to be involved in the heterotypic adhesion of malignant T cells to epithelia (27) as well as in T cell homotypic adhesion (28).The ADAM (a disintegrin and metalloprotease) proteins, also called MDC (metalloprotease/disintegrin/Cys-rich), are a family of membrane-anchored glycoproteins that present * This work was supported in part by National Institutes of Health Grants R24-DK064399, DK061941, DK071594 (to D. M.), DK061417 (to A. T. G.), and DK55850 (to S. V. S.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

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“…The presence of these antibodies constitutes sensitization of the person and creates the potential for various types of immunologie reactions upon re-exposure to the specific antigen. In addition to sensitization by humoral antibodies, there is the possibility of antigen induction of specific cell-mediated immunity (11,12).…”

Section: Sensitizationmentioning

confidence: 99%

A Modern Clinical Approach to Food Hypersensitivity

May

Block

1978

Allergy

107

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Intraepithelial Lymphocyte Counts in Small Intestinal Biopsies From Children With Diarrhoea

Cited by 89 publications

References 13 publications

The Clinical Significance of Duodenal Lymphocytosis With Normal Villus Architecture

The Clinical Significance of Duodenal Lymphocytosis With Normal Villus Architecture

ADAM-15/Metargidin Mediates Homotypic Aggregation of Human T Lymphocytes and Heterotypic Interactions of T Lymphocytes with Intestinal Epithelial Cells

A Modern Clinical Approach to Food Hypersensitivity

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