Intrafamilial aggregation and heritability of office−day blood pressure difference in a community of African ancestry

Djami-Tchatchou, Arnaud T.; Norton, Gavin R.; Redelinghuys, Michelle; Maseko, Muzi J.; Majane, Olebogeng H.I.; Woodiwiss, Angela J.

doi:10.1097/mbp.0000000000000069

Cited by 2 publications

(3 citation statements)

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“… 16 Within South Africa, data are also emerging that BP is heritable across families (parent–child and sibling–sibling pairs). 17 However, due to the high levels of hypertension in South African adults, hypertension in a family member is unlikely on its own to be a sensitive enough indicator to identify at-risk young adults or children for intervention.…”

Section: Introductionmentioning

confidence: 99%

“…Studies of monozygotic and dizygotic twins have shown high heritability of systolic blood pressure (SBP) and diastolic blood pressure (DBP) in populations of both African and European decent,14 15 though heritability may be lower for individuals of African decent 16. Within South Africa, data are also emerging that BP is heritable across families (parent–child and sibling–sibling pairs) 17. However, due to the high levels of hypertension in South African adults, hypertension in a family member is unlikely on its own to be a sensitive enough indicator to identify at-risk young adults or children for intervention.…”

Section: Introductionmentioning

confidence: 99%

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Are cardiovascular health measures heritable across three generations of families in Soweto, South Africa? A cross-sectional analysis using the random family method

et al. 2022

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ObjectivesCardiovascular disease is increasing in many low and middle-income countries, including those in Africa. To inform strategies for the prevention of cardiovascular disease in South Africa, we sought to determine the broad heritability of phenotypic markers of cardiovascular risk across three generations.DesignA cross-sectional study conducted in a longitudinal family cohort.SettingResearch unit within a tertiary hospital in a historically disadvantaged, large urban township of South Africa.Participants195 individuals from 65 biological families with all three generations including third-generation children aged 4–10 years were recruited from the longest running intergenerational cohort study in Africa, the Birth to Twenty Plus cohort. All adults (grandparents and parents) were female while children were male or female.Primary and secondary outcome measuresThe primary outcome was heritability of blood pressure (BP; brachial and central pressures). Secondary outcomes were heritability of arterial stiffness (pulse wave velocity), carotid intima media thickness (cIMT) and left ventricular mass indexed to body surface area (LVMI).ResultsWhile no significant intergenerational relationships of BP or arterial stiffness were found, there were significant relationships in LVMI across all three generations (p<0.04), and in cIMT between grandparents and parents (p=0.0166). Heritability, the proportion of phenotypic trait variation attributable to genetics, was estimated from three common statistical methods and ranged from 23% to 44% for cIMT and from 21% to 39% for LVMI.ConclusionsStructural indicators of vascular health, which are strong markers of future clinical cardiovascular outcomes, transmit between generations within African families. Identification of these markers in parents may be useful to trigger assessments of preventable risk factors for cardiovascular disease in offspring.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Are cardiovascular health measures heritable across three generations of families in Soweto, South Africa? A cross-sectional analysis using the random family method

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Studies of mono- and dizygotic twins have shown high heritability of systolic and diastolic blood pressure in populations of both African and European decent 12 13 , though heritability may be lower for individuals of African decent 14 . Within South Africa, data is also emerging that blood pressure is heritable across families (parent-child, and sibling pairs) 15 . However, due to the high levels of hypertension in South African adults, hypertension in a family member is unlikely on its own to be a sensitive enough indicator to identify at risk young adults or children for intervention..…”

Section: Introductionmentioning

confidence: 99%

Heritability of cardiovascular health across three generations in South Africa: the Birth to Twenty-Plus cohort

Ware

Maposa

Kolkenbeck‐Ruh

et al. 2022

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ObjectivesCardiovascular disease is increasing in many low-middle income countries, including those in Africa. To inform strategies for the prevention of cardiovascular disease in South Africa, we sought to determine the broad heritability of phenotypic markers of cardiovascular risk across three generations.DesignA cross-sectional study conducted in a longitudinal family cohort.SettingResearch unit within a tertiary hospital in a historically disadvantaged, large urban township of South Africa.Participants195 individuals from 65 biological families with all three generations including third generation children aged 4-10 years were recruited from the longest running intergenerational cohort study in Africa, the Birth to Twenty Plus cohort. All adults (grandparents and parents) were female, while children were male or female.Primary and secondary outcome measuresThe primary outcome was heritability of blood pressure (BP, brachial and central pressures). Secondary outcomes were heritability of arterial stiffness (pulse wave velocity), carotid intima media thickness (cIMT), and left ventricular mass indexed to body surface area (LVMI).ResultsWhile no significant intergenerational relationships of BP or arterial stiffness were found, there were significant relationships in LVMI across all three generations (p<0.04), and in cIMT between grandparents and parents (p=0.0166). Heritability estimates were 23-44% for cIMT and 21-39% for LVMI.ConclusionsStructural indicators of vascular health, which are strong markers of future clinical cardiovascular outcomes transmit between generations within African families. Identification of these markers in parents may be useful to trigger assessments of preventable risk factors for cardiovascular disease in offspring.StrengthsIntergenerational transmission was evaluated for a range of indicators of cardiovascular health within urban African familiesThe sample included biological family members from three generationsHeritability estimates were compared for three commonly used statistical methods.LimitationsThe sample size is a limitation with the random family statistical method used to increase the numbers of comparisons available.Only maternal family members were included.

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Intrafamilial aggregation and heritability of office−day blood pressure difference in a community of African ancestry

Abstract: Although office and ambulatory BP may show similar heritability estimates, genetic associations with carefully determined office BP measurements may be confounded by the heritability of office-day BP differences.

Cited by 2 publications

References 22 publications

Are cardiovascular health measures heritable across three generations of families in Soweto, South Africa? A cross-sectional analysis using the random family method

Are cardiovascular health measures heritable across three generations of families in Soweto, South Africa? A cross-sectional analysis using the random family method

Heritability of cardiovascular health across three generations in South Africa: the Birth to Twenty-Plus cohort

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