Intrafamilial clustering of hepatitis B virus (HBV) infection: study of 10 Saudi families

Ramia, S.

doi:10.1080/00034983.1990.11812518

Cited by 8 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, as is also shown in our study, Aribas et al, found a significant relationship between family size and HBs positivity in central Turkey [22]. Szmuness et al [28], Toukan et al [6] and Ramia et al [29] showed that family size affected HBV transmission in the household and increased proportionately with the number of children in the family. But there are some controversial reports concerning the role of family size in the transmission of HBV infection [30,31].…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Intra-familial spread of hepatitis B virus infection in eastern Turkey

et al. 2007

View full text Add to dashboard Cite

Hepatitis B virus (HBV) infection is a worldwide health problem. The aim of the present study was not only to determine the prevalence of HBsAg in children of HBV-infected parents but also to identify all HBSAg-positive family members to protect as many children, in the present and future, as possible. The study was carried out with the participation of 2113 family members (1205 children, 453 mothers, and 455 fathers) at Sivas SSK Hospital, Turkey. They were screened for HBV markers using standard enzyme immunoassay between September 2001 and March 2005. The prevalence of any HBV markers and HBsAg among family members of index cases was 50.5% and 30.5% respectively. HBsAg carrier rate was higher among fathers (61%) than mothers (47%), (P<0.05). The children of mother index cases had higher rates of HBsAg compared with the children of father index cases (P<0.01). Our results suggest that intra-familial childhood horizontal transmission (especially mother-to-child) is important for HBV transmission in the Turkish community, and highlights the need for screening of adult siblings and mothers of adult HBsAg carriers in addition to their spouses and children.

show abstract

Section: Discussionsupporting

confidence: 82%

“…[6] and Ramia et al . [29] showed that family size affected HBV transmission in the household and increased proportionately with the number of children in the family. But there are some controversial reports concerning the role of family size in the transmission of HBV infection [30, 31].…”

Section: Discussionmentioning

confidence: 99%

Intra-familial spread of hepatitis B virus infection in eastern Turkey

et al. 2007

View full text Add to dashboard Cite

show abstract

“…In patients whose fathers were positive for liver disease, it was interesting to note that all such patients were the eldest sons. It is reported that HBV might be transmitted horizontally from the father to infant; although horizontal transmission from father to infant in the case of hepatitis C cannot be excluded, there is no evidence for horizontal transmission in this study [Whittle et al, 1983;Langendorfer et al, 1984;Ramia, 1990;Diago et al, 1996]. In the patient whose brother had liver disease, the mode of infection would be similar as both siblings were exposed to the same life style at early life (parenteral medication and casual contact, etc.).…”

Section: Discussionmentioning

confidence: 59%

Risk factors of hepatitis C virus‐related liver cirrhosis in young adults: Positive family history of liver disease and transporter associated with antigen processing 2 (TAP2) *0201 Allele

Akuta

Chayama

Suzuki

et al. 2001

Journal of Medical Virology

View full text Add to dashboard Cite

The aim of this study was to clinically characterize young patients with hepatitis-C-related cirrhosis. We compared 27 patients with liver cirrhosis (Group LC) who were anti-HCV positive, aged 40 years or less at the time of diagnosis, with 323 consecutive patients with HCV-related chronic hepatitis (Group CH) matched for age and gender. Furthermore, Group LC was divided into two arbitrary groups (29-35 years, n = 8 /36-40 years, n = 19), based on the age of patients at the time of diagnosis of liver cirrhosis. Patients' characteristics and family history were investigated, and the frequency of transporter associated with antigen processing 2 (TAP2) was determined. A family history of liver disease was present in 40.7% of Group LC but in 18.0% of Group CH (P < 0.05). The younger the age of diagnosis of cirrhosis in Group LC, the higher the frequency of a positive family history (29-35 years, 87.5%; 36-40 years, 21.1%, P < 0.05). The frequency of TAP2*0201 was significantly higher in young adult patients with HCV-related liver cirrhosis than in HCV carriers with normal ALT (P < 0.05), and tended to be higher than in uninfected normal subjects (P = 0.05). The cumulative survival rate of cirrhosis patients with family history of liver diseases was significantly lower than that of cirrhosis patients without such history (P < 0.05). Our findings suggest that a positive family history of liver disease and TAP2*0201 polymorphism may be risk factors for HCV-related liver cirrhosis in young adults.

show abstract

“…The intrafamilial transmission rates also increase as the number of people living at the same house increase (Cakaloglu et al,1992; Kuyucu et al,1998; Ramia,1990; Sampliner et al,1981; Toukan et al,1990). In our study, HBsAg positivity rates were higher in families consisting of five or more members compared to families with fewer than five members.…”

Section: Discussionmentioning

confidence: 99%

Familial clustering of HBV in families with children who are diagnosed as chronic hepatitis B or inactive carriers of HBV

Urgancı

Akyıldız

Kalyoncu

et al. 2013

J Child Health Care

View full text Add to dashboard Cite

The aim of this study was to assess and compare the spread of HBV infection in families with children who are diagnosed as chronic hepatitis B or are inactive carriers of HBV. A total of 570 patients aged 2-16 years and 2358 family members were included in the study. Patients were classified as inactive carriers (Group 1, 350 patients) or patients diagnosed as chronic active hepatitis B (Group 2, 220 patients). Demographic features of the families, HBV serological markers and routes of transmission were evaluated. Parental transmission was lower compared to nonparental transmission (34.8% and 65.1%, respectively). HBsAg positivity rate was found to be highest among mothers in both of the groups. HBeAg positivity and anti-HBs positivity were significantly higher in family members of Group 2. Transmission rates were significantly higher in families consisting of five or more members compared to families consisting of less than five members. HBsAg positivity of siblings was lowest when both parents were HbsAg negative and highest when both parents were HBsAg positive in both groups. A high risk of HBV transmission among mothers of HBsAg carriers and patients with chronic hepatitis B was demonstrated.

show abstract

Intrafamilial clustering of hepatitis B virus (HBV) infection: study of 10 Saudi families

Cited by 8 publications

References 23 publications

Intra-familial spread of hepatitis B virus infection in eastern Turkey

Intra-familial spread of hepatitis B virus infection in eastern Turkey

Risk factors of hepatitis C virus‐related liver cirrhosis in young adults: Positive family history of liver disease and transporter associated with antigen processing 2 (TAP2) *0201 Allele

Familial clustering of HBV in families with children who are diagnosed as chronic hepatitis B or inactive carriers of HBV

Contact Info

Product

Resources

About