Intrafamilial Correlations of Carotid Intima–Media Thickness and Flow-Mediated Dilation in a Siberian Population

Ryabikov, A.; Malyutina, Sofia; Ryabikov, M.; Kuznetsova, Tatiana; Staessen, Jan A.; Nikitin, Yu. P.

doi:10.1016/j.amjhyper.2006.09.005

Cited by 12 publications

(7 citation statements)

References 29 publications

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“…In recent years, the weight of inherited factors on carotid IMT (“heritability”) has been investigated in general population samples of different ethnicities13 – 15 or in selected samples of individuals with a family history of different cardiovascular diseases 16 – 20. Wang et al 18 demonstrated, in a multivariate-adjusted model, a heritability of 40% for carotid IMT in adult offspring of patients with a history of coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

Early increase of carotid intima-media thickness in children with parental history of premature myocardial infarction

Barra¹,

Gaeta²,

Cuomo

et al. 2008

Heart

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Background/objective: Increased carotid intima-media thickness (IMT) is an early manifestation of atherosclerosis. Our group has previously demonstrated that a parental history of premature myocardial infarction (PHPMI) is associated with an increase in carotid IMT in children-adolescents (mean age 13 years) and young adults (mean age 24 years). The aim of the present study was to evaluate if carotid structural changes are detectable in young children with PHPMI. Methods: 26 healthy children (9 males and 17 females; 5-12 years, mean age 9.1 (2.5) years) with PHPMI and 26 age-matched (plus or minus 1 year), sex-matched and body mass index-matched (BMI; plus or minus 20%) control subjects were enrolled in the study. They underwent high resolution B-mode ultrasonographic evaluation of common carotid artery IMT. Lipid profile, resting blood pressure and BMI were also evaluated. Results: Compared to controls, subjects with PHPMI had increased IMT of common carotid arteries (mean of combined sites: 0.444 (0.076) mm versus 0.382 (0.062) mm in controls, p = 0.001). Offspring of coronary patients showed an unfavourable lipid profile compared to controls; however, the association between a PHPMI and carotid IMT was independent of lipids, apolipoproteins and other traditional risk factors. Conclusions: Vascular structural changes are detectable in subjects with PHPMI at a young age and occur independently of several traditional cardiovascular risk factors.Atherosclerosis starts during childhood.

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Section: Discussionmentioning

confidence: 99%

Early increase of carotid intima-media thickness in children with parental history of premature myocardial infarction

Barra¹,

Gaeta²,

Cuomo

et al. 2008

Heart

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“…20 In the analysis, we used the mean IMT estimate from either the right or the left artery, whichever was higher. 22 …”

Section: Methodsmentioning

confidence: 99%

Prevalence and Predictors of Carotid Wall Triple Line Pattern in a General Population Sample

Ryabikov¹,

Malyutina²,

Halcox³

et al. 2011

ATVB

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Objective Carotid intima-media thickness (IMT) and plaques are markers of atherosclerosis and predict cardiovascular events. A specific sonographic triple line pattern (TLP) of the carotid wall has been identified in different conditions, but its origin and clinical significance are unclear. We examined the prevalence and predictors of TLP in a general population. Methods and Results The study was conducted in random sample of the general population of Novosibirsk, Russia, within the international Health, Alcohol and Psychosocial Factors in Eastern Europe project. In a subsample of 418 men (aged 45 to 69), carotid IMT, the presence of atherosclerotic plaques, and the presence of TLP were assessed by ultrasound. The prevalence of TLP was 21%. It was associated with IMT (odds ratio=9.53 per 1 SD, P<0.001) and the presence of plaques (odds ratio=2.42, P=0.002). Other predictors of TLP in multivariate models included age, systolic blood pressure, total cholesterol, and smoking. In addition, infrequent consumption of high amounts of alcohol approximately doubled the risk of triple pattern. Conclusion Our findings showed high prevalence of TLP of carotid wall in a general male population sample from a typical Russian city. This sonographic pattern was strongly associated with cardiovascular risk factors and diseases, bioimaging indicators of atherosclerosis, and episodic heavy drinking.

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“…Furthermore, twin and family studies suggest endothelial function or FMD is a heritable trait. A significant familial aggregation was reported for FMD measured in 81 nuclear families with a heritability estimate of 0.58 for FMD in sibling pairs (Ryabikov et al, 2007). The Northern Manhattan Family Study reported heritability for FMD of 0.17 in Hispanic Caucasians after adjusting for age, sex, and cardiovascular disease (CVD) risk factors (Suzuki et al, 2008).…”

Section: Genetic Regulation Of Endothelial Function In Humansmentioning

confidence: 99%

Genetic Regulation of Endothelial Vasomotor Function

Kim

Massett

2016

Front. Physiol.

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The endothelium plays an important role in the regulation of vasomotor tone and the maintenance of vascular integrity. Endothelial dysfunction, i.e., impaired endothelial dependent dilation, is a fundamental component of the pathogenesis of cardiovascular disease. Although endothelial dysfunction is associated with a number of cardiovascular disease risk factors, those risk factors are not the only determinants of endothelial dysfunction. Despite knowing many molecules involved in endothelial signaling pathways, the genetic contribution to endothelial function has yet to be fully elucidated. This mini-review summarizes current evidence supporting the genetic contribution to endothelial vasomotor function. Findings from population-based studies, association studies for candidate genes, and unbiased large genomic scale studies in humans and rodent models are discussed. A brief synopsis of the current studies addressing the genetic regulation of endothelial responses to exercise training is also included.

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Intrafamilial Correlations of Carotid Intima–Media Thickness and Flow-Mediated Dilation in a Siberian Population

Abstract: Our findings confirm that a substantial proportion of the variability of carotid IMT and brachial FMD is attributable to genetic variation. They also suggest that offspring share more genetic or environmental determinants of FMD with fathers than their mothers.

Cited by 12 publications

References 29 publications

Early increase of carotid intima-media thickness in children with parental history of premature myocardial infarction

Early increase of carotid intima-media thickness in children with parental history of premature myocardial infarction

Prevalence and Predictors of Carotid Wall Triple Line Pattern in a General Population Sample

Genetic Regulation of Endothelial Vasomotor Function

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