Intrafamilial prevalence of hepatitis B virus in Western Brazilian Amazon region: Epidemiologic and biomolecular study

Lobato, Cirley; Tavares-Neto, José; Rios-Leite, Márcio; Trépo, C.; Vitvitski, L.; Parvaz, Parviz; Zoulim, Fabien; Júnior, Argemiro D’Oliveira; Paraná, Raymundo

doi:10.1111/j.1440-1746.2006.04298.x

Cited by 55 publications

(67 citation statements)

References 17 publications

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“…Studies carried out in the Amazon region suggest that HBV transmission is associated with living with an HBV carrier and with sharing items of personal use. 6,7 We observed a high prevalence rate of total anti-HDV in these three areas. Notably, similar rates were reported in the Amazon region 26,52,53 suggesting that HDV has not yet disappeared from HBV hyperendemic areas.…”

mentioning

confidence: 78%

“…Vertical transmission does not appear to be significant, but intra-family transmission, associated with the presence of an HBV carrier is commonly described. 6,7 The HBV is classified into 10 genotypes (A to J), originally distributed within specific populations. Human migrations and miscegenation defined the pattern of geographical distribution observed today.…”

Section: Introductionmentioning

confidence: 99%

“…51 The molecular data confirmed the household nature of HBV transmission in this population, as described previously in the Amazon. 7 However, among children 1 to 14 years of age, in which the majority of chronic carriers and potential transmitters were concentrated, it was not possible to identify the transmission mechanisms. Studies carried out in the Amazon region suggest that HBV transmission is associated with living with an HBV carrier and with sharing items of personal use.…”

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confidence: 99%

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Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Castilho

Oliveira

Gimaque

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Individuals from three isolated, rural communities in the western Brazilian Amazon were evaluated for serological markers of hepatitis B virus (HBV) infection, HBV genotype, and the presence of risk factors for infection and transmission. Of the 225 individuals studied, 79.1% had serological evidence of HBV infection; 10.2% individuals were chronic carriers for HBV surface antigen (HBsAg-positive). Analysis of risk factors indicates that HBV is transmitted mainly horizontally within the family from a chronic "active" carrier for hepatitis B "e" antigen (HBeAgpositive), though a strong possibility of vertical transmission remains. The predominance of HBV genotype F, with a higher genomic similarity between the isolates, indicated a relatively recent introduction of HBV, from a common source, to the area. This study sheds light on the HBV epidemiology in the Brazilian Amazon region and highlights the need for greater emphasis on HBV control and immunization programs.

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confidence: 78%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Castilho

Oliveira

Gimaque

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…In Brazil, the presence of genotype G has been rarely seen (Lobato et al 2006, Mendes-Correa et al 2008. Bottecchia et al (2008) identified genotype G in a patient infected with HBV only and in two patients co-infected with HIV.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B genotype G and high frequency of lamivudine-resistance mutations among human immunodeficiencyvirus/hepatitis B virus co-infected patients in Brazil

Silva

Spina

Lemos

et al. 2010

Mem. Inst. Oswaldo Cruz

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In this study, we evaluated the hepatitis B virus (HBV) genotype distribution and HBV genomic mutations among a group of human immunodeficiency virus-HBV co-infected patients from an AIDS outpatient clinic in São Paulo. HBV serological markers were detected by commercially available enzyme immunoassay kits. HBV DNA was detected using in-house nested polymerase chain reaction and quantified by Cobas Amplicor. HBV genotypes and mutations in the basal core promoter (BCP)/pre-core/core regions and surface/polymerase genes were determined by sequencing. Among the 59 patients included in this study, 55 reported prior use of lamivudine (LAM) or tenofovir. HBV DNA was detected in 16/22 patients, with a genotype distribution of A (n = 12,75%), G (n = 2,13%), D (n = 1,6%) and F (n = 1,6%). The sequence data of the two patients infected with genotype G strongly suggested co-infection with genotype A. In 10 patients with viremia, LAM-resistance mutations in the polymerase gene (rtL180M + rtM204V and rtV173L + rtL180M + rtM204V) were found, accompanied by changes in the envelope gene (sI195M, sW196L and sI195M/sE164D). Mutations in the BCP and pre-core regions were identified in four patients. In conclusion, genotype G, which is rarely seen in Brazil, was observed in the group of patients included in our study. A high prevalence of mutations associated with LAM-resistance and mutations associated with anti-HBs resistance were also found among these patients

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“…In this same area, Lobato et al (2006) showed intrafamilial transmission to be the most important route of HBV dissemination in Acre. Once more, the high prevalence of genotype A and F was reported [10].…”

Section: Epidemiological Datamentioning

confidence: 99%

Hepatotropic viruses in the Brazilian Amazon: a health threat

2008

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Intrafamilial prevalence of hepatitis B virus in Western Brazilian Amazon region: Epidemiologic and biomolecular study

Abstract: Intrafamilial transmission of HBV is evident in the present study and is possibly associated with the presence of more than one HBV carrier in the family and the shared use of toothbrushes among household contacts. Genotype analysis confirms intrafamilial transmission.

Cited by 55 publications

References 17 publications

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Hepatitis B genotype G and high frequency of lamivudine-resistance mutations among human immunodeficiencyvirus/hepatitis B virus co-infected patients in Brazil

Hepatotropic viruses in the Brazilian Amazon: a health threat

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