“…All ZRS variants tested in this study, including previously published human variants (Al-Qattan et al, 2012;Albuisson et al, 2011;Baas et al, 2017;Cai et al, 2019;Cho et al, 2013;Farooq et al, 2010;Furniss et al, 2008;Girisha et al, 2014;Gurnett et al, 2007;Heutink et al, 1994;Lettice et al, 2003;Lodder, 2009;Norbnop et al, 2014;Semerci et al, 2009;VanderMeer et al, 2012;Vanlerberghe et al, 2015;Wieczorek et al, 2010;Wu et al, 2016;Zguricas et al, 1999;Zhang et al, 2019), variants from animals (Dorshorst et al, 2010;Dunn et al, 2011;Knudsen and Kochhar, 1981;Lettice et al, 2008;Masuya et al, 2007;Zhao et al, 2009) and novel variants reported in this study. Table S1 contains the following columns: variant coordinate in GRCh38 genome assembly (1 st column), relative position within the ZRS enhancer (2 nd column), reference and variant alleles (3 rd column), variant name (4 th column), organism of origin (5 th column), VISTA ID of the tested construct containing the human ZRS enhancer with the variant (6 th column), variant classification based on the enSERT result (7 th column), reference (8-9 th columns), clinical phenotypes and human genetics data for variants from human patients (10-24 th columns), PhyloP scores (25 th column), predicted TF binding sites…”